심혈관 질환과 관련된 심리적인 요인과 행동적 요인 - 스트레스와 성격을 중심으로 -

한창환,Han, Chang-Hwan 한국정신신체의학회 1995 정신신체의학 Vol.3 No.2

The author conducted a literature review to better characterize the current state of knowledge regardeding the relationship between psychological and behavioral factors and cardiovascular disease. This review focus on several Problems : hypertension, coronary artery disease such as myocardial infarction and angina pectoris, sudden death, arrhythmia, vasomotor(vasodepressor) syncope, and psychogenic cardiac nondisease. We describe model for understanding the relationship of psychological factors to the disease, review the results of relevant research studies and provide recommendation for further research.

신경전달물질 및 신경내분비 Marker를 이용한 치료반응의 평가

한창환,Han, Chang-Hwan 대한생물정신의학회 1995 생물정신의학 Vol.2 No.1

Numerous investigators have conducted extensive investigation in the search for biological markers in psychiatric illness. There are, as a test of q biological approach to the diagnosis of the psychiatric illness, tests for the neurotransmitters, their metabolites, and related enzymes, the neurotransmitter receptors, the neuroendocrine output and response, the membrane transport, peptides and eletrolytes. They are called the biological markers, and they are helpful for the diagnosis or differential diagnosis, choice of treatment or drugs, symptom improvement, predictor of recurrence and anticipation of suicidal attempt. These studies are among the main purposes that are pursued in the neuroscience and based on the potential utility of the biological markers mentioned above. Since 1970's, lots 01 biological markers' studies for the diagnosis, differential diagnosis or subtypes differentiation have been done but varieties of different opinions have been drawn since then through they could explain the charaters of main psychiatric illness(especially schizophrenia and mood disorder). But, the search for biological markers, including displines of neuroendoclinology and neurochemistry(neurotransmitter and thair metabolite), has yielded a number of putative trait merkers and state markers for psychayric illness. This paper aims to anticipate or evaluate the good response to the therapy(Therpeutic response) with lots of markers. Acoording to the diagnosis of lots of diseases or subtypes, we are going to review the papers, mainly concern with 'Is there any Marker' or 'Is any test possible to detect the improvement clinically?' 'Is it possible to predict the recurrence or good prognsis?' or 'Is it possible to select any drug or therapy to bring the good response?' The biological tests to review are mainly the metabolites of catecholamine neurotransmitter, and especially neuroendocrine test based on the knowledge that hormons of the adenohypophysis are influenced by activity of the cerebral or limbic neurons as well as the hypothalamus ones. Among them, author introduced some clinically available tests that are DST, TRH stimulation test(TRHST), GH stimulation test, and the urine MHPG test that can give us the evaluation of the treatment response, the predictor for recurrence or choice of drug that can bring a good response. So author discussed thair potential utility in clarifying, therapeutic, and prognostic issues in psychatric illness. We hope they'll be used and look forward to more active study on the different opinion.

PC 그라드 환경을 위한 오픈 API 개발 동향 및 사례

한창환,한연희,길준민,윤준원,최장원,Han, Chang-Hwan,Han, Youn-Hee,Gil, Joon-Min,Yoon, Jun-Weon,Choi, Jang-Won 한국콘텐츠학회 2008 한국콘텐츠학회지 Vol.6 No.4

탄소섬유 복합재료 사각튜브의 압추에너지 흡수 특성

한창환,김근택,이종원,최윤호,Han, Chang-Whan,Kim, Keun-Taek,Lee, Jong-Won,Choi, Youn-Ho 한국항공우주연구원 2002 항공우주기술 Vol.1 No.2

본 연구는 탄소섬유 복합재료 사각튜브의 압축 에너지 흡수 특성을 실험적으로 규명하였으며, 유한요소해석을 통해서 그 특성을 예측하였다. 압축 속도는 0.003mm/sec 와 0.3mm/sec로 하여 사각튜브에 가하였으며, 적층각 별로 실험을 하여 각각에 대한 압축 에너지 흡수 특성인 최대 압축하중과 평균하중을 찾았다. [0/90]₄와 [0/±45/90]₂의 특정 적층각을 가지는 사각튜브에 대해 유한요소해석을 수행하여 최대 압축하중을 예측하였다. 유한요소모델은 좌굴해석을 통해서 나온 형상과 원래 형상을 중첩하였으며, 해석방법은 Tsai-Wu criteria를 사용하였다. 실험으로부터 최대 압축하중은 인 사각튜브에서 나타났고 평균 압축하중은에서 나타났으며, 특정각을 가지는 사각튜브에 대한 최대 압축하중 예측은 실험과 거의 일치하였다. Crush energy characteristics of graphite/epoxy square tubes are experimentally studied. Effect of the ply orientation on the peak load and the average load is investigated by applying compressive load on the top of the composite square tubes under the stroke control with crosshead speed of 0.003mm/sec and 0.3mm/sec. in addition to the experimental survey, the finite element analysis is used to estimate the peak load of the composite square tubes with [0/90]₄ and [0/±45/90]₂. The first buckling mode of the tube is superimposed to the perfect geometry and the distributed compressive load is applied on the top of the tubes. The applied compressive load that make Tsai-Wu criteria equal to one is regarded as the peak load of the tubes. The experimental data shows that the square tube with [45/-45]₄ has the highest peak load and the square tube with [60/-60]₄ has the average sustained load. The measure peak load of the composite tubes with [0/90]₄ and [0/±45/90]₂agree well with the estimated peak load using the finite element analysis.

정신분열병(精祥分裂病) 환자(患者)의 사회적(社會的) 지지망(支持網) 분석(分析)

한창환,김광진,석재호,Han, Chang-Hwan,Kim, Kwang-Jin,Suk, Jae-Ho 한국정신신체의학회 1996 정신신체의학 Vol.4 No.2

This study was designed to evaluate the social support network of schizophrenic patients. 64 schizophrenic patients being treated as out-door patient were compared with 30 neurotic control patients. Schizophrenics were divided into positive, subpositive, subnegative and negative subgroups by present symptom and social network of both schizophrenics and control group were evaluated. The results are as follows: 1) Social network of schizophrenics was smaller than that of control group. Size of social network of schizophrenics was 10.6 and that of control group was 23.5. 2) In both kin and nonkin, social network of schizophrenics was smaller than that of control group. Of the kin, schizophrenics were more supported by wife or husband, father, and mother, but were less supported by brother, son and other relatives. 3) There was no difference in the kin or nonkin or total supporters between the four subgroups of schizophrenics. But, subgroup of schizophrenics which was divided as having negative symptom had smaller network than control group in active formal and informal supporters. 4) When divided into 4 support areas, schizophrenics was remarkably less supported in emotional, instrumental and appraisal support area than control group, but there was no difference in the informational support areas. 5) Compared with control group, schizophrenics more often mentioned parent and ten often mentioned nonkin supporter as the one that is most important to him. 6) Schizophrenics had smaller cluster and less leisure activity than control group. Subgroup of schizophrenics who was divided as having negative symptom had less frequency of leisure activity than other subgroups.

우울증 아형들의 이해

한창환,류성곤,Han, Chang-Hwan,Ryu, Seong Gon 대한생물정신의학회 2001 생물정신의학 Vol.8 No.1

우울증으로 고통받는 많은 환자들에서 보이는 다양항 양상과 다양한 경과를 자주 접하면서 분류를 어떻게 하여야 임상적으로 유용한가 의문을 가지게 된다. 이에 저자들은 우울증의 아형 평가의 필요성과 평가도구들을 문헌을 통하여 고찰하였다. 원래부터 이들이 이질적인 집단으로 구성되어 있는지, 하나의 유전적 소인이 있어 개인에 따라서 병의 진행 시기에 따라서 여러 우울증의 spectrum으로 표현되는 것인지 문제가 제기되어 왔지만, 현재로서는 분명히 알 수 없다. 저자들은 먼저 "우울증 스펙트럼" "양극성 우울과 단극성 우울이 공통의 하나의 유전적 인자를 가지는가" "양극성 스펙트럼 장애"등 강한 주장들이 있어 문헌 고찰을 통해서 알아보았다. 그리고, 최근 생물학적인 연구로부터 나온 세로토닌 관련 우울증 가설을 알아보았다. 이 우울증 가설(SeCA depression)은 조기 모성 분리 혹은 모성 박탈 같은 유년시절의 부정적 경험, 불안, 공격성, co-rtisol 증가, cortisol flattening, DST 양성, 스트레스 사건, CRF 상승, 5HIAA저하 등을 연결하여 우울증의 역동을 쉽게 설명하였고 생물-심리-사회적 접근을 가능하게끔 하는 우울증의 모델이다. 둘째로 고전적인 생물학적 지표 즉 DST, TRH 자극 검사, 및 뇨 MHPG 검사 결과에 따르는 우울증 아형을 구분하고 특징을 살펴보았고 이들의 역사적이고 임상적인 의미를 알아보았다. 그밖에 APOE epsilon 4 allele, 기질-성격이론(Temperament Character Inventory : TCI) 심박동 변이도(heart rate variability : HRV) 같은 요인들을 비롯하여 잘 알려진 증상이나 진단으로 분류된 아형들을 조사하여 임상적인 의미를 찾아보았다. The debate about whether depressive disorders should be divided into categories or arrayed along a continuum has gone for decade, without resolution. In our review, there is more evidence consistent with the spectrum concept than there is with the idea that depressive disorders constitute discrete clusters marked by relatively discontinuous boundaries. First, "depression spectrum", "is there a common genetic factors in bipolar and unipolar affective disorder", "threshold model of depression" and "bipolar spectrum disorder" are reviewed. And, a new subtype of depression is so called SeCA depression that is a stressor-precipitated, cortisol-induced, serotonin-related, anxiety/aggression-driven depression. SeCA depression is discussed. But, there is with the idea that depressive disorders constitute discrete subtypes marked by relatively discontinuous boundaries. This subtypes of depressive disorder were reviewed from a variety of theoretical frames of reference. The following issues are discussed ; Dexamethasone suppression test(DST), TRH stimulation test, MHPG, Temperament Character Inventory(TCI), and heart rate variability(HRV).

항공기용 유압 시스템 신뢰도 및 정비도 분석 프로세스 고찰

한창환,김근배,Han, ChangHwan,Kim, KeunBae 한국시스템엔지니어링학회 2016 시스템엔지니어링학술지 Vol.12 No.1

An aircraft must be designed to minimize system failure rate for obtaining the aircraft safety, because the aircraft system failure causes a fatal accident. The safety of the aircraft system can be predicted by analyzing availability, reliability, and maintainability of the system. In this study, the reliability and the maintainability of the hydraulic system are analysed except the availability, and therefore the reliability and the maintainability analysis process and the results are presented for a helicopter hydraulic system. For prediction of the system reliability, the failure rate model presented in MIL-HDBK-217F is used, and MTBF is calculated by using the Part Stress Analysis Prediction and quality/temperature/environmental factors described in NPRD-95 and MIL-HDBK-338B. The maintainability is predicted by FMECA(Failure Mode, Effect & Criticality Analysis) based on MIL-STD-1629A.

'의학적 상태에 영향을 미치는 심리적 요인들' 심혈관계 질환의 모형 개발

한창환,Han, Chang-Hwan 한국정신신체의학회 1998 정신신체의학 Vol.6 No.2

The author conducted a literature review to better characterize the current state of knowledge regarding the relationship between psychological and behavioral factors and cardiovascular disease. This review focus on several problems : Hypertension, coronary artery disease such as myocardial infarction and angina pectoris. We describe model for understanding the relation-ship of psychological factors to the disease, review the results of relevant research studies and provide recommendation for further research.

골 침범없이 상완요골근에 발생한 결핵 농양

한창환(Chang-Whan Han),김원유(Weon-Yoo Kim),고락현(Lak-Hyun Ko),전진성(Jin-Sung Cheon),김진영(Jin-Young Kim) 대한견주관절의학회 1999 대한견주관절학회지 Vol.2 No.2

항공기 개발사업을 위한 기술성과측정방법 연구

한창환(Chang-Hwan Han),최석(Seok Choi),김승범(Seung-Bum Kim) 한국항공우주연구원 2005 항공우주기술 Vol.4 No.2