정신분열병(精祥分裂病) 환자(患者)의 사회적(社會的) 지지망(支持網) 분석(分析)

한창환,김광진,석재호,Han, Chang-Hwan,Kim, Kwang-Jin,Suk, Jae-Ho 한국정신신체의학회 1996 정신신체의학 Vol.4 No.2

This study was designed to evaluate the social support network of schizophrenic patients. 64 schizophrenic patients being treated as out-door patient were compared with 30 neurotic control patients. Schizophrenics were divided into positive, subpositive, subnegative and negative subgroups by present symptom and social network of both schizophrenics and control group were evaluated. The results are as follows: 1) Social network of schizophrenics was smaller than that of control group. Size of social network of schizophrenics was 10.6 and that of control group was 23.5. 2) In both kin and nonkin, social network of schizophrenics was smaller than that of control group. Of the kin, schizophrenics were more supported by wife or husband, father, and mother, but were less supported by brother, son and other relatives. 3) There was no difference in the kin or nonkin or total supporters between the four subgroups of schizophrenics. But, subgroup of schizophrenics which was divided as having negative symptom had smaller network than control group in active formal and informal supporters. 4) When divided into 4 support areas, schizophrenics was remarkably less supported in emotional, instrumental and appraisal support area than control group, but there was no difference in the informational support areas. 5) Compared with control group, schizophrenics more often mentioned parent and ten often mentioned nonkin supporter as the one that is most important to him. 6) Schizophrenics had smaller cluster and less leisure activity than control group. Subgroup of schizophrenics who was divided as having negative symptom had less frequency of leisure activity than other subgroups.

신경전달물질 및 신경내분비 Marker를 이용한 치료반응의 평가

한창환,Han, Chang-Hwan 대한생물정신의학회 1995 생물정신의학 Vol.2 No.1

Numerous investigators have conducted extensive investigation in the search for biological markers in psychiatric illness. There are, as a test of q biological approach to the diagnosis of the psychiatric illness, tests for the neurotransmitters, their metabolites, and related enzymes, the neurotransmitter receptors, the neuroendocrine output and response, the membrane transport, peptides and eletrolytes. They are called the biological markers, and they are helpful for the diagnosis or differential diagnosis, choice of treatment or drugs, symptom improvement, predictor of recurrence and anticipation of suicidal attempt. These studies are among the main purposes that are pursued in the neuroscience and based on the potential utility of the biological markers mentioned above. Since 1970's, lots 01 biological markers' studies for the diagnosis, differential diagnosis or subtypes differentiation have been done but varieties of different opinions have been drawn since then through they could explain the charaters of main psychiatric illness(especially schizophrenia and mood disorder). But, the search for biological markers, including displines of neuroendoclinology and neurochemistry(neurotransmitter and thair metabolite), has yielded a number of putative trait merkers and state markers for psychayric illness. This paper aims to anticipate or evaluate the good response to the therapy(Therpeutic response) with lots of markers. Acoording to the diagnosis of lots of diseases or subtypes, we are going to review the papers, mainly concern with 'Is there any Marker' or 'Is any test possible to detect the improvement clinically?' 'Is it possible to predict the recurrence or good prognsis?' or 'Is it possible to select any drug or therapy to bring the good response?' The biological tests to review are mainly the metabolites of catecholamine neurotransmitter, and especially neuroendocrine test based on the knowledge that hormons of the adenohypophysis are influenced by activity of the cerebral or limbic neurons as well as the hypothalamus ones. Among them, author introduced some clinically available tests that are DST, TRH stimulation test(TRHST), GH stimulation test, and the urine MHPG test that can give us the evaluation of the treatment response, the predictor for recurrence or choice of drug that can bring a good response. So author discussed thair potential utility in clarifying, therapeutic, and prognostic issues in psychatric illness. We hope they'll be used and look forward to more active study on the different opinion.

우울증 아형들의 이해

한창환,류성곤,Han, Chang-Hwan,Ryu, Seong Gon 대한생물정신의학회 2001 생물정신의학 Vol.8 No.1

우울증으로 고통받는 많은 환자들에서 보이는 다양항 양상과 다양한 경과를 자주 접하면서 분류를 어떻게 하여야 임상적으로 유용한가 의문을 가지게 된다. 이에 저자들은 우울증의 아형 평가의 필요성과 평가도구들을 문헌을 통하여 고찰하였다. 원래부터 이들이 이질적인 집단으로 구성되어 있는지, 하나의 유전적 소인이 있어 개인에 따라서 병의 진행 시기에 따라서 여러 우울증의 spectrum으로 표현되는 것인지 문제가 제기되어 왔지만, 현재로서는 분명히 알 수 없다. 저자들은 먼저 "우울증 스펙트럼" "양극성 우울과 단극성 우울이 공통의 하나의 유전적 인자를 가지는가" "양극성 스펙트럼 장애"등 강한 주장들이 있어 문헌 고찰을 통해서 알아보았다. 그리고, 최근 생물학적인 연구로부터 나온 세로토닌 관련 우울증 가설을 알아보았다. 이 우울증 가설(SeCA depression)은 조기 모성 분리 혹은 모성 박탈 같은 유년시절의 부정적 경험, 불안, 공격성, co-rtisol 증가, cortisol flattening, DST 양성, 스트레스 사건, CRF 상승, 5HIAA저하 등을 연결하여 우울증의 역동을 쉽게 설명하였고 생물-심리-사회적 접근을 가능하게끔 하는 우울증의 모델이다. 둘째로 고전적인 생물학적 지표 즉 DST, TRH 자극 검사, 및 뇨 MHPG 검사 결과에 따르는 우울증 아형을 구분하고 특징을 살펴보았고 이들의 역사적이고 임상적인 의미를 알아보았다. 그밖에 APOE epsilon 4 allele, 기질-성격이론(Temperament Character Inventory : TCI) 심박동 변이도(heart rate variability : HRV) 같은 요인들을 비롯하여 잘 알려진 증상이나 진단으로 분류된 아형들을 조사하여 임상적인 의미를 찾아보았다. The debate about whether depressive disorders should be divided into categories or arrayed along a continuum has gone for decade, without resolution. In our review, there is more evidence consistent with the spectrum concept than there is with the idea that depressive disorders constitute discrete clusters marked by relatively discontinuous boundaries. First, "depression spectrum", "is there a common genetic factors in bipolar and unipolar affective disorder", "threshold model of depression" and "bipolar spectrum disorder" are reviewed. And, a new subtype of depression is so called SeCA depression that is a stressor-precipitated, cortisol-induced, serotonin-related, anxiety/aggression-driven depression. SeCA depression is discussed. But, there is with the idea that depressive disorders constitute discrete subtypes marked by relatively discontinuous boundaries. This subtypes of depressive disorder were reviewed from a variety of theoretical frames of reference. The following issues are discussed ; Dexamethasone suppression test(DST), TRH stimulation test, MHPG, Temperament Character Inventory(TCI), and heart rate variability(HRV).

'의학적 상태에 영향을 미치는 심리적 요인들' 심혈관계 질환의 모형 개발

한창환,Han, Chang-Hwan 한국정신신체의학회 1998 정신신체의학 Vol.6 No.2

The author conducted a literature review to better characterize the current state of knowledge regarding the relationship between psychological and behavioral factors and cardiovascular disease. This review focus on several problems : Hypertension, coronary artery disease such as myocardial infarction and angina pectoris. We describe model for understanding the relation-ship of psychological factors to the disease, review the results of relevant research studies and provide recommendation for further research.

심혈관 질환과 관련된 심리적인 요인과 행동적 요인 - 스트레스와 성격을 중심으로 -

한창환,Han, Chang-Hwan 한국정신신체의학회 1995 정신신체의학 Vol.3 No.2

The author conducted a literature review to better characterize the current state of knowledge regardeding the relationship between psychological and behavioral factors and cardiovascular disease. This review focus on several Problems : hypertension, coronary artery disease such as myocardial infarction and angina pectoris, sudden death, arrhythmia, vasomotor(vasodepressor) syncope, and psychogenic cardiac nondisease. We describe model for understanding the relationship of psychological factors to the disease, review the results of relevant research studies and provide recommendation for further research.

PC 그라드 환경을 위한 오픈 API 개발 동향 및 사례

한창환,한연희,길준민,윤준원,최장원,Han, Chang-Hwan,Han, Youn-Hee,Gil, Joon-Min,Yoon, Jun-Weon,Choi, Jang-Won 한국콘텐츠학회 2008 한국콘텐츠학회지 Vol.6 No.4

이공학편 : 퍼지이론을 이용한 소형 항공기 글라이드 슬로프 자동 착륙 연구

한창환(책임연구원) ( Chang Hwan Han ),김근택(책임연구원) ( Keun Taek Kim ) 공군사관학교 2015 空士論文集 Vol.66 No.2

정보처리나 자동제어분야에서 퍼지이론은 학계의 많은 관심을 불러일으켰으며 로붓, 의료진단, 인공지능 등 실질적인 산업분야에 새로운 패러다음을 가져왔다. 퍼지제어 (Fuzzy Control)는 시변시스템(Time-Varying System)과 비선형 시스템(Nonlinear System) 혹은 쉽게 정의하기 어려운 프로세스 시스템을 제어하는데 있어 고전적인 제어기법들을 대체하기 위한 하나의 대안으로 등장하였다. 이러한 흐름에 따라 고정익 소형항공기의 Glide-slope 자동 착륙 시스템에 퍼지 제어 이론을 적용하기 위한 연구를 수행하였다. 본 연구에서는 향후 퍼지이론을 다양한 응용분야에 적용할 수 있도록 확장성과 활용성을 가지도록 FMRLC를 퍼지 제어기로 선정하였으며, 항공기의 자동착륙경로에 대한 Glide-Slope 착륙거동을 모델링하여 항공기의 운동방정식을 유도하고 Matlab을 이용한 해석 및 시뮬레이션을 통해 퍼지제어의 타당성을 검증하였다. Fuzzy theory is a new paradigm for the fields of information processing and automatic control such as robot, medical science. artificial intelligence etc. Fuzzy control has been also emerged as a practical alternative to classical control schemes in controlling certain lime- varying system, nonlinear system. and ill-defined processes. In this paper Funy Model Reference Learning Controller(FMRLC) is designed for a glide-slope automatic landing of a small airpiane la find applicability and expandabililY of the fuzzy theory. In addition. mathematical modeling for the glide-slope landing path is performed and the equation of motion is fannulated for the glide- slope automatic landing behavior. The perfomlance of FMRLC is demonstrated by simulation using the Matlab and the results are presented.

복합재료 선미익 항공기 날개 하중해석

한창환(Chang-Hwan Han),김응태(Eung-Tai Kim),안석민(Seok-Min Ahn),김진원(Jin-Won Kim) 한국항공우주연구원 2002 항공우주기술 Vol.1 No.1

정신신체 의학의 정신과학적 접근

한창환(Han Chang-Hwan) 대한스트레스학회 2002 스트레스硏究 Vol.10 No.2

국제 및 국내 시험인정시스템에 관한 동향 조사

한창환(Han, Chang-hwan) 한국항공우주연구원 2015 항공우주산업기술동향 Vol.13 No.1

세계 각국은 국제 자유무역을 원활하게 하기 위하여 관세를 폐지하고, 세계를 하나로 묶는 국제화 시대를 만들어가고 있다. 그러나 이면에는 자국의 산업보호를 위해 보이지 않는 또 다른 장벽을 만들고 있다. 즉, 표면적으로는 안전성등의 여러가지 이유를 내세우고 있지만 자국의 시험인정을 받아야만 수입이 허가되는 등 수입규제를 하고 있다. 이러한 문제를 해결하기 위해 시험, 검사 및 교정 등에 대하여 상호인정을 해주는 국제시험인정기구가 설립되었으며, 우리나라도 KOLAS라고 하는 한국공인인정기구를 두고 있다. 여기서 세계 각 지역별 인정기구 및 역할에 대하여 알아보고 또한 국내 시험인정기구를 살펴보기로 한다. Many countries have removed income tariffs for promotion of the free trade. On the other hand, they make technical barriers enforcing to meet their quality standards to protect their home industries. To resolve these issues the international accreditation cooperation was established to mutually accept a product when the product is tested once and accepted everywhere. South Korea has a accreditation organization called KOLAS. In this report, some basic roles of the international and regional organizations of the world including the KOLAS in Korea are presented.