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감초에서 분리된 데하드로글라이아스페린 C에 의한 마우스 모델계에서 quinone reductase 활성의 조절
한정화,김정상,Han, Jung-Hwa,Kim, Jong-Sang 경북대학교 농업과학기술연구소 2013 慶北大農學誌 Vol.31 No.1
예로부터 다양한 방면에서 약용식물로 널리 사용되어 온 감초에서 분리한 dehydroglyasperin C (DGC)는 이전의 연구에서 세포 모델계에서 비교적 높은 항산화 능력과 2상 해독효소계 활성을 유도하는 것이 확인되었으나, 동물 모델계에서 DGC의 항산화능과 2상 해독효소계를 평가하였을 때, 유의적 결과가 관찰되지 않았다. 따라서 DGC 처리시간에 따라 마우스의 장기 및 혈장에 어떠한 영향을 미치는지를 알아보고자 0, 2, 4, 6, 8, 12, 24 시간 동안 DGC를 처리한 후, 장기별 QR 유도활성과 간과 신장에서의 단백질 발현 패턴, 혈장의 항산화능력을 측정하였다. 그 결과 DGC 처리에 의한 QR 유도활성은 위, 대장에서 시간에 따라 변화하는 경향을 보였고, 간, 신장, 소장, 폐에서는 큰 경향성이 나타나지 않았으며, 2상 해독효소의 단백질 발현 패턴은 간에서는 역시 큰 경향성이 나타나지 않았고 위에서는 QR 유도활성과 유사한 경향이 나타남을 확인하였다. 혈장의 DGC 처리 시간에 따른 항산화활성은 시간에 따라 유의적으로 값이 증가한 것을 확인할 수 있었다. 결론적으로 DGC는 처리 시간에 따라 각 장기 및 혈장에 각기 다르게 영향을 미치는 것으로 사료되며, 앞으로도 추가적인 연구를 통하여 DGC의 효능을 보다 구체적으로 검증하는 것이 필요한 것으로 생각된다. Licorice, Glycyrrhizae radix, is one of the oldest and most frequently used botanicals in the oriental medicine. Our previous study showed that dehydrolyasperin C (DGC) isolated from licorice had antioxidant activity and induced phase 2 detoxifying enzymes in mouse hepatoma cells. Therefore, this study was conducted to investigate the effect of exposure time to DGC on quinone reductase (QR), one of the anticarcinogenic biomarkers, and antioxidant potential of plasma using animal model. ICR mice were divided into 7 groups, in which mice in each group were injected with DGC (5 mg/kg b.w.) for 0, 2, 4, 6, 8, 12, 24 hours respectively. Following the treatment the organs including liver, kidney, lung, stomach, large intestine, small and large intestines were collected and subjected to QR activity assay, western blotting, and FRAP assay. Exposure to DGC caused a significant induction of QR activity in stomach and large intestine of mice. Ferric reducing activity of plasma, a typical biomarker for antioxidative potentialshowed that DGC improved antioxidant potential in mice. However, no significant effect of DGC was observed in the other organs.
한정화,김수종,Han, Cheong-Hwa,Kim, Soo-Jong 한국세라믹학회 2012 한국세라믹학회지 Vol.49 No.5
The nano-sized zirconia powders were synthesized in an impregnation method using pulp and $ZrOCl_2{\cdot}8H_2O$ as an initial material. The synthesized powders were characterized by XRD and FE-SEM. The particle size of the powder was controlled by preparation conditions, such as drying temperature and time. As a result of the various drying and calcination conditions, 30~50 nm sized homogeneous zirconia particles were obtained at $800^{\circ}C$ for 1 h. Crystallization and the rapid growth of particles were accelerated with increasing calcination temperature and time. Tetragonal phase generated below $800^{\circ}C$ were transferred to monoclinic phase with increasing calcination temperature and time. Moreover, above $800^{\circ}C$, heat treatment time had very large influence on the particle growth, and the change of drying condition also had large influence on the growth of a crystal.
함침법에 의한 Y(P,V)O<sub>4</sub>:Eu<sup>3+</sup> 형광체의 합성 및 발광특성
한정화,김수종,Han, Cheong-Hwa,Kim, Soo-Jong 한국세라믹학회 2011 한국세라믹학회지 Vol.48 No.6
The $Eu^{3+}$ doped $Y(P_x,V_{1-x})O_4$ (0 ${\leq}$ x ${\leq}$ 1) phosphors were synthesized by solid-state and impregnation method and investigated as potential red-emitting phosphors for a plasma display panel(PDP). The optimal substitution proportion of P for V was determined to be 60 mol%, for $Y(P_x,V_{1-x})O_4$ doped with 8 mol% $Eu^{3+}$. The VUV PL spectra and SEM for the synthesized phosphors were measured and compared against those of a commercial red-emission phosphor. The $Y(P_x,V_{1-x})O_4$:$Eu^{3+}$ phosphors exhibited strong red at around 592, 618 and 698 nm. The emission intensity and particle size of the phosphors were controlled by preparation conditions.
한정화,김수종 한라대학교 2006 論文集 Vol.9 No.-
In order to improve the performance of red emitting phosphors for plasma display panel(PDP), the (Y,Gd)₂O₃ Eu phosphors were synthesized using impregnation method with polymer precursors and studied using SEM and VUV photoluminescence spectrometer Under 147 nm excitation, (Y,Gd)₂O₃ Eu phosphor exhibits a strong red emission around 615 nm The particle size is in the range between 150 and 200 nm The emission intensity and particle size of powders were controlled by sintering temperature and raw material composition As a result, we have found that particle size was very uniform and PL luminance characteristic was excellent about twice than commercial red phosphor
졸겔법에 의한 LED용 Ca₃MgS₁₂O_(8):Eu 청색형광체의 합성
한정화 한라대학교 2009 論文集 Vol.12 No.-
In order to improve the luminescent efficiency we have synthesized the Ca₃MgS₁₂O_(8):Eu phosphors for UV LEDs (Light Emittine Diodes) by sol-gel technique Advantages of this technique are the homogeneity and purity of gels and relatively low sintering temperatures Such advantages are important for the preparation of monolithic products When the phosphor prepared by sol-gel technique reaction factors such as pH condition Rw drying temperature were affect the luminescent intensity particle size and morphology of final product Therefore we attempt to control these reaction factors in order to improve the luminescent efficiency of phosphors for UV LED
도시주부의 과거. 현재. 미래측면에서 본 주관적 경제복지감
한정화,최덕경,최동숙 안성산업대학교 1999 論文集 Vol.31 No.-
Economic welfare of a family is regarded as utilization of the flow of goods and services on which the family has command from its production and consumption. The purpose of this study is to investigate some influencing factors related to the urban housewives' subjective economic well-being. Questionnaires were used to the 1800 housewives in Seoul from the end of September to the end of October in 1996. The 1261 data obtained were analyzed by Frequency, Percentage, mean, t-test, F-test, Duncan's Posthoc Test, and Stepwised Multiple Regression with SPSS PC^+. The major finding of this study were summarized as follows; (1) There were significant differences on the subjective economic well-being for the urban housewives according to the social demographic variables (housewives' age, education and healthy condition). (2) There were significant differences on the subjective economic well-being for the urban housewives according to the objective variables (residence price, income, savings, debt and education). (3) There were significant differences on the subjective economic well-being for the urban housewives according to the perceptions of the economic conditions (working satisfaction, the perception of the relative comparison, the government policy for the price and the tax, the perception of the living standards and the subjective social class). (4) There were significant differences on the subjective economic well-being for the urban housewives according to the leisure and family variables (children number, the family life cycle, leisure satisfaction, the coincidence of the conjugal opinion and the types of the conjugal buying decision. The current government and the education policy should be reevaluated and revised for the improvement of the housewives' welfare.