신경전도검사의 정상치에 관한 연구

한송이,김대성,박규현,Han, Song-Yee,Kim, Dae-Seong,Park, Kyu-Hyun 대한임상신경생리학회 1999 Annals of Clinical Neurophysiology Vol.1 No.2

Background and Aims : Nerve conduction study is invaluable in clinical neurology, especially for assessing peripheral neuropathies. Abnormal nerve conduction studies may result not only from peripheral nerve dysfunction itself, but also from other various mechanical, technical, and physiological factors such as age, sex, height and temperature. So we conducted this study to establish the our own normal values. Methods : In this study, from March. 1997 to July. 1998, 40 Korean adults among person came to Health Promotion Center over the age of 20 without any suspicion of neurological deficits were analysed to determine the effect of compound effects of several physiological factors. Results : The nerve conduction velocities of the upper extremity and proximal segments were faster than those of the lower extremity and distal segments. Physiological factors such as age, height and temperature affect the results of nerve conduction studies in multiple regression analysis. The sex difference is recognized over peroneal motor nerve. There are no sex differences in amplitude transformed into normal distribution. The significant physiological factor affecting the amplitude of nerve conduction is age, whereas height and temperature play no role. Conclusions : In multiple regression analysis, height is widespread variable for the nerve conduction velocities and temperature is important variable for lower extremities. The parametric statistical analysis cannot be applied to the amplitude of the compound muscle or nerve action potentials because of marked left shift in distribution. Sqareroot transformation of the CMAP and CNAP may be useful in normalizing the distribution. The most significant physiological factor affection the amplitude is age. Sex differences are not seen in nerve conduction study.

고속전철 부속실 풍경 디자인

한송이(Han Song-Yee),이선영(Lee Sun-Young),최혁수(Choi Hyok-Su),이병종(Lee Byeong-Jong) 한국디자인학회 2000 디자인학연구 Vol.- No.38

직장인 대학원생의 지식교량적 역할이 MBA 조직 내 지식공유 네트워크에 미치는 영향

한송이 ( Song Yee Han ),조일현 ( Il Hyun Jo ) 한국지식경영학회 2012 지식경영연구 Vol.13 No.4

The purpose of this study is to investigate the effects of employees who attend graduate school on the expansion of the knowledge sharing network in their company. For this purpose, the researchers chose 10 worker-graduate students and 75 members of company ``A`` that they belong to and 107 members of university ``B`` that they belong to, 172 members in total. 10 overlapped employee-students were excluded. The results of this study are summarized as follow: First, the personal relations of the employee-students enhanced after they have entered the graduate school. The score for the question was 3.85 out of 5 points. Second, the employee-students played the role of the knowledge bridge between company`s co-worker network and graduate school`s classmate network. It was confirmed that the density of the company`s network was higher than the density of the connected network of the company and the graduate school. The analysis result confirmed that the difference of the two groups was significant. This means that the company carried out exchange with more members and therefore gained various kinds of knowledge. Also, in all types of network, the structural hole of the company network was lower than that of the connected network of the company and graduate school. The ANOVA test using QAP procedure confirmed that the difference of two groups was significant (friendship network F=1.2856, p<0.05; information network F=1.278, p<0.05; and trust network F=1.23, p<0.05). It means that the company not only gained the newly acquired knowledge by the knowledge bridge of the employee-students, but also was able to share it more effectively with members. Third and lastly, the employee-students share various information related to the organization, duties and roles rest in the company throughout break time, working hours and direct inquiries. This means that the employee-students contributed to the innovation of knowledge sharing in the company by sharing knowledge that they gained from the graduate school within the company.

감염 ; 폐외 결핵 진단에서 2개의 전혈 인터페론 감마 측정법의 유용성 비교

한송이 ( Song Yee Han ),이혁 ( Hyuck Lee ),정동식 ( Dong Sik Jung ),김경희 ( Kyeong Hee Kim ),우수미 ( Su Mi Woo ),박소영 ( So Young Park ),서정민 ( Jeong Min Seo ),정진규 ( Jin Kyu Jung ),윤늘봄 ( Neul Bom Yoon ),이성우 ( Sung W 대한내과학회 2011 대한내과학회지 Vol.81 No.4

목적: QuantiFERON-TB GOLD (QFT-G)와 QuantiFERON-TB GOLD in tube (QFT-IT) 검사는 주로 활동성 폐결핵 또는 잠복결핵의 진단과 관련되어 연구되어져 왔으나, 폐외 결핵의 진단과 유용성은 아직 잘 밝혀지지 않은 상태이다. 본 연구는 폐외 결핵 환자에서 QFT-G와 QFT-IT의 진단적 유용성에 대해 비교 분석하였다. 방법: 2007년 6월부터 2010년 8월까지 임상적으로 폐외결핵이 의심되어 QFT-G, QFT-IT 검사를 한 환자 각각 56명과 48명을 대상으로 하였다. QFT-G와 QFT-IT의 민감도, 특이도, 양성예측도, 음성예측도와 QFT-IT의 cut-off value를 통하여 진단적 유용성을 분석하였다. 결과: 폐외 결핵으로 진단된 환자는 55명(53%)이었고 QFT-IT의 민감도, 특이도, 양성예측도, 음성예측도는 96%, 42%, 62%, 91%이었으며, QFT-G는 81%, 52%, 68%, 68%이었다. 감염부위에 따른 검사 결과 또한 민감도, 음성예측도에서 QFT-IT가 QFT-G보다 더 높은 결과를 보였다. 본 연구에서 cut-off value는 기존에 권고하고 있는 cut-off value의 범위 안에 포함되었다(0.30-0.45 IU/mL, sensitivity 95.8%, specificity 41.7%). 결론: QFT-IT는 M.tuberculosis 감염의 진단에 있어서 QFT-G보다 높은 민감도와 음성예측도를 보이며, 특이도에 있어서는 유사한 결과를 보여 새로운 IGRA방법으로서 폐외결핵의 진단을 더 강화시킬 수 있는 가능성을 보여주었다. Background/Aims: The QuantiFERON-TB Gold (QFT-G) and QuantiFERON-TB Gold in tube (QFT-IT) assays have been studied primarily for the use of diagnosing active pulmonary tuberculosis (TB) or latent TB. The clinical usefulness of these assays for the detection of active extrapulmonary (EP) TB has not been fully defined. The aim of this study was to compare the diagnostic value of these two interferon-gamma assays for EP-TB. Methods: From June 2007 to August 2010, we evaluated the usefulness of QFT-G (n=56) and QFT-IT (n=48) in patients (n=104) with suspected EP-TB. The diagnostic sensitivity, specificity, postive predictive value (PPV), and negative predictive value (NPV) of QFT-G and QFT-IT, and the cut-off value of QFT-IT were analyzed. Results: EP-TB was diagnosed in 55 (53%) patients. The overall sensitivity, specificity, PPV, and NPV of the QFT-IT assay were 96%, 42%, 62%, and 91%, respectively, and those of the QFT-G test were 81%, 52%, 68%, and 68%, respectively. In subgroup analyses according to infection site, the sensitivity and NPV of QFT-IT were higher than those of QFT-G. Analysis confirmed that the manufacturer`s recommended test cut-off value fell within our cut-off value range (0.30-0.45 IU/mL; 95.8% sensitivity, 41.7% specificity). Conclusions: The QFT-IT assay showed superior sensitivity and NPV, and equivalent specificity, as comparison with the QFT-G test for the detection of Mycobacterium tuberculosis infection. The logistic benefits of the QFT-IT test format should facilitate the diagnosis of EP-TB. (Korean J Med 2011;81:478-486)

천(天)-지(地)-인(人) 시스템 디자인 연구 (2)

한송이(Han Song-yee),권용(Kwon Yong),유연수(Yu Yeon-su),이상혁(Lee Sang-hyuck),임정은(Lim Jung-eun),김명석(Kim Myung-suk),안용일(An Yong-il),이경훈(Lee Kyung-hoon),한명희(Han Myung-hee) 한국디자인학회 2001 디자인학연구 Vol.- No.41

AV시스템의 디자인 결정요소 분석

한송이(Han Song-Yee),이병종(Lee Byeong-Jong) 한국디자인학회 2001 디자인학연구 Vol.- No.41

생명체의 구조색을 모방한 대면적 광결정 구조의 제작

서한복(Han-Bok Seo),이동준(Dongjun Lee),한송이(Song Yee Han),허남회(Nam Hwi Hur),이승엽(Seung-Yop Lee) 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.11

Many researches on artificially fabricated photonic crystal structures has been developed in various fields. Recently, a great attention has been paid on the coloring technology mimicking the structural colors of the living organisms such as Morpho butterfly and peacock. However, previously developed methods have limitations to fabricate 3-dimensional photonic crystals in large scales without defection. In this paper, we propose a new fabrication method for the large-scale photonic crystal structures generating structural colors by improving and combining the dip coating and capillary methods.

악성 상피성 난소종양에서 Ki-67의 발현에 관한 연구

박창민 ( Chang Min Park ),한송이 ( Song Yee Han ),김인선 ( In Sun Kim ),김현철 ( Hyun Chul Kim ),강재성 ( Jae Seong Kang ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.11

목적: 세포증식지수인 Ki-67을 면역조직화학적 염색하여 상피성 난소암종의 예후인자인 수술적 병기, 조직학적 유형, 조직학적 분화도, 치료 전 혈청 CA-125와의 관계를 분석하여 예후인자들과 연관성을 알아보고 독립적인 예후 인자로 가치여부를 구명하고자 한다. 방법: 1994년 1월부터 2005년 12월까지 고려의대 안암병원 산부인과에서 난소암종으로 개복수술한 100명의 환자에서 수술 후 얻은 난소조직을 대상으로 하여 Ki-67에 대한 MIB-1단클론 항체를 사용하여 면역조직화학 염색을 시행 후 핵에 진한 갈색으로 염색된 세포수를 종양세포수의 백분율로 표시하였다. 결과: KI-67 과발현은 총 100명 중 63예 (63.0%)이고, 병기에 따른 과발현은 병기 I 및 II기에서 각각 42.9%, 33.3%, 병기 III 및 IV에서 각각 72.4%, 66.7%로 저병기 (I, II)보다 고병기 (III, IV)에서 과발현되어 통계학적으로 유의한 차이가 있었다. 조직학적 유형에 따른 Ki-67의 과발현은 장액성 암종에서 76.3%, 점액성 암종, 자궁내막양 암종 및 투명세포암종에서 각각 53.6%, 54,5%, 58.3%로 장액성 암종에서 타 유형에서보다 발현이 많았으나 통계학적으로 유의성은 없었다. 분화도에 따른 Ki-67의 과발현은 분화도 3에서 70.9%, 분화도 1 및 2에서 각각 50.0%, 54.5%로 분화도가 나쁜 경우 Ki-67의 발현율이 높았으나 통계학적인 유의성은 없었다. 치료 전 혈청 CA-125에 따른 Ki-67의 과발현은 CA-125가 높은 경우 증가하는 경향은 있으나 통계학적인 의의는 없었다. Ki-67단백의 과발현은 난소의 상피성 암종의 생존기간에 유의한 감소가 있었다. 결론: Ki-67의 과발현은 치료예후를 예측할 수 있는 인자로 활용할 수 있다고 판단된다. Objective: The study was to evaluate the biological significance of Ki-67 expression in common epithelial ovarian carcinomas. We investigated the correlation between Ki-67 expression and clinicopathological parameters. Methods: One hundred patients with epithelial ovarian carcinomas stage I-IV treated at Department of Obstertrics and Gynecology, Korea University Hospital from January 1994 to December 2004 were used as study group. We determined expression of Ki-67 by immunohistochemistry using MIB-1 monoclonal antibody reactivity. Results: Ki-67 overexpression was higher in high stage (III-IV) than low stage (I-II) (P<0.013). Ki-67 overexpression was higher in serous cystadenocarcinoma (76.3%) than mucinous cystadenocarcinoma (53.6%), endometrioid carcinoma (54.5%) and clear cell carcinoma (58.3%) but it was not statistically significant (P<0.191). Ki-67 expression was higher in high grade but it was not statistically significant (P<0.096). Ki-67 overexpression was not correlated with serum CA-125 level (P<0.172). Overall survival revealed significant survival difference between patients whose tumor showed Ki-67 overexpressions compared with remaining patients. Conclusions: Ki-67 overexpressions was a poor prognostic indicator in epithelial ovarian carcinomas.

고속전철 객실 유연성 디자인

최혁수(Choi Hyok-Su),권용(Kwan Yong),한송이(Han Song-Yee),이병종(Lee Byeong-Jong) 한국디자인학회 2000 디자인학연구 Vol.- No.38

天-地-人 시스템 디자인 연구 (Ⅰ)

이상혁(Lee Sang-hyuck),권용(Kwon Yong),유연수(Yu Yeon-su),임정은(Lim Jung-eun),한송이(Han Song-yee),김명석(Kim Myung-suk),안용일(An Yong-il),이경훈(Lee Kyung-hoon),한명희(Han Myung-hee) 한국디자인학회 2001 디자인학연구 Vol.- No.41