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韓瑞璟 서울大學校 保健大學院 1966 公衆保健雜誌 Vol.3 No.2
The purpose of this investigation was carried out to conform the result of legal or illegal artificial dyes using in marketing food. The experment was made toward 147 food stuff which a mainly sold in the market places,including juices, drops and candies. The study was conducted from August 1 to October 1 in 1966. The following conclusions were obtained: 1.Legaly approved dyes were used in 55.78% of 147 cases and illegal dyes were used in 44.22% of 147 cases. 2.Illegal dyes were found less frequently in the drops and candies bearing trade -names than in those without trade-names. 3.Scarlet, Rhodamin B and Auramin mainly occupy 80% of illegal dyes found in the study. 4.Twenty nine cases were mixture of two dyes and 62.07% of all mixed dyes were those with blue and yellow. 5.Out of 29 cases mixed with two dyes, only 17.25% of them were found as legal in both dyes,82.75% of them were found to be legal in one dyes only, and none of them was found as illegal in both dyes.
Understanding noninferiority trials
한서경 대한소아청소년과학회 2012 Clinical and Experimental Pediatrics (CEP) Vol.55 No.11
Noninferiority trials test whether a new experimental treatment is not unacceptably less efficacious than an active control treatment already in use. With continuous improvements in health technologies,standard care, and clinical outcomes, the incremental benefits of newly developed treatments may be only marginal over existing treatments. Sometimes assigning patients to a placebo is unethical. In such circumstances, there has been increasing emphasis on the use of noninferiority trial designs. Noninferiority trials are more complex to design, conduct, and interpret than typical superiority trials. This paper reviews the concept of noninferiority trials and discusses some important issues related to them.
간접비교를 통한 보건의료기술의 유용성 평가에서 분석결과의 타당성 확보를 위한 조건
한서경 ( Seo Kyung Hahn ),김윤희 ( Youn Hee Kim ),장은진 ( Eun Jin Jang ),안정훈 ( Jeong Hoon Ahn ),강수희 ( Sun Hee Kim ),김선희 ( Soo Hee Kang ) 한국보건정보통계학회 (구 한국보건통계학회) 2011 한국보건정보통계학회지 Vol.36 No.2
Objectives: The study aims to identify and discuss the concept of the key assumption on which the indirect comparisons rely and to illustrate a practical approach to assure the validity. Methods: We firstly reviewed the theoretical background of the indirect comparisons and then suggested how the key assumptions can be assessed and accounted for using an example of common reference based indirect comparison. Results: The fundamental assumption behind the synthesized comparative effect obtained by indirect comparison is that the same effect would still be obtainable if it was directly measured in all of the trials that constitute the indirect comparison. An illustrative analysis demonstrated that conducting an indirect comparison without a meticulous assessment for the exchangeability could mislead the conclusion on the comparative effectiveness. Conclusions: Head-to-head trials could provide the most valid estimate of the comparative effect of a healthcare intervention. When competing interventions have not been evaluated in direct randomized trials or there is little available source by those trials, indirect comparisons may be utilized to provide an estimate of the comparative effect. However, the limitations also need to be highlighted, since the indirect comparison methodology relies upon certain important but conceptual and essentially unverifiable key assumption.