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하채명,이지영,이욱상,남기범,이동윤 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
Poly(acrylic acid) (PAA) hydrogel is widely used as biomedical materials due to their biocompatibility. However, hydrogel has disadvantages of low mechanical and adhesion properties. We fabricated a UV-curable hydrogel adhesive with high tack property, peel strength, and adhesive force by adding additives. Herein, the modified cellulose nanofiber (m-CNF) and silica nanoparticles (SNPs) were exploited as additives to increase the internal cohesion of hydrogel adhesive introducing physical bonding networks between the carboxymethyl group of m-CNF and the hydroxyl group of the SiO2 NPs in the hydrogel. Furthermore, cytotoxicity test and drug release test ascertained that hydrogel has an availability as a drug carrier. According to the results, it was expected that this hydrogel nanocomposites could be applied as transdermal drug delivery system.
Preparation of Hydrogel Adhesive using m-CNF and Silica Nanoparticles
하채명,이동윤 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
In this study, we added m-CNF and SiO₂ NPs to hydrogel adhesive to enhance mechanical and adhesive properties of it. After simply mixing all components, hydrogel adhesive was easily cured with UV polymerization. The result of PAA/m-CNF/SiO₂ hydrogel was analyzed by field emission scanning electron microscope (FE-SEM), probe tack test, peel test, universal test machine (UTM), swelling test. As the surface of m-CNF was replaced with carboxymethyl group, it could be dispersed without agglomeration in the polymer matrix. Since the hydroxyl groups of the SiO₂ NPs and the carboxymethyl groups of m-CNF formed physical bonds, internal cohesion was increased. When SiO₂ NPs are added, the viscosity of the solution can be controlled by mixing with m-CNF, which greatly contributed to the improvement of physical properties.
Properties of UV Curable Acrylic PSA with Surface-Modified Silica Nanoparticles
이욱상,이지영,하채명,박근태,남기범,박은영,김세현,이동윤 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
In this study, we fabricated a UV-curable acrylic pressure sensitive adhesives (PSAs) which has surface modified silica nanoparticles (m-SNPs). Acrylic copolymers, such as 2-EHA/AA or 2-EHA/IBOA, were prepared as an adhesive resin through UV polymerization. M-SNPs were modified using octadecyltrichlorosilane and (3-Aminopropyl)tiethoxysilane to control the surface wettability of nanoparticles. We determined adhesion, thermal, and mechanical properties of PSAs composites using UTM and TGA. Furthermore, the dispersity of m-SNPs in acrylic resins were investigated by scanning electron microscope. PSAs can be applied in the field of display panel, mobile industry, and packaging.
박상미,전재한,민병걸,하채명,THOUDAMTHEMIS,박보윤,이인규 대한당뇨병학회 2018 Diabetes and Metabolism Journal Vol.42 No.4
Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex (PDC), which acts as a central metabolic node that mediates pyruvate oxidation after glycolysis and fuels the Krebs cycle to meet energy demands. Fine-tuning of PDC activity has been mainly attributed to post-translational modifications of its subunits, including the extensively studied phosphorylation and de-phosphorylation of the E1α subunit of pyruvate dehydrogenase (PDH), modulated by kinases (pyruvate dehydrogenase kinase [PDK] 1-4) and phosphatases (pyruvate dehydrogenase phosphatase [PDP] 1-2), respectively. In addition to phosphorylation, other covalent modifications, including acetylation and succinylation, and changes in metabolite levels via metabolic pathways linked to utilization of glucose, fatty acids, and amino acids, have been identified. In this review, we will summarize the roles of PDC in diverse tissues and how regulation of its activity is affected in various metabolic disorders.
Mechanical Properties of Polyolefin Elastomer with Cellulose Nanofiber
남기범,이욱상,이지영,하채명,이동윤 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
Plastic waste is appearing as a serious threat to environment, because of its non-biodegradable property. Therefore, cellulose fibers from wood, starch, and bacteria attracted the attention of many research groups due to its biodegradability, flexibility, and mechanical properties to overcome the problems of ordinary plastics. In this work, we fabricated polyolefin elastomer (POE) compounds that contain 80phr of cellulose nanofiber (CNF). To disperse CNF into POE, we adopted two types of POE as a base resin and found optimal composition of them. Dispersed CNF improves Young’s modulus and tensile stress of POE forming micro aggregation in the POE mixtures. The dispersion and aggregation of CNF was observed by SEM and EDS images by the contents of POE and CNF. This study can be applied to rubbery materials that need high mechanical properties and biodegradability such as gasket of vehicles, shoe sole, and packaging.
Improve of Impact Property on PLA/PBAT for Sustainable Packaging
이지영,남기범,이욱상,하채명,류진원,이동윤 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
With the growth of single-use plastic production, the need for biodegradable polymers has increased to reduce plastic wastes. polylactic acid (PLA) has excellent tensile strength as well as biodegradable ability. However, the stiffness of PLA is an obstacle to widen its application such as plastic bag, packaging, and carriers. In this study, poly(butylene adipate-co-terephthalate) (PBAT), an elastic biopolymer, was blended with PLA to improve mechanical property adding poly(butyl acrylate) (PBA) as a compatibilizer. Morphology, mechanical and dynamic viscoelastic properties according to the different content of compatibilizers were analyzed by UTM, FE-SEM and DMA. As a result, it can be applied to a green material such as eco-friendly packaging, coating and disposables.