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하윤석,양진혁,원석희,이명수,Ha, Yun-Sok,Yang, Jin-Hyuk,Won, Seok-Hee,Yi, Myung-Su 대한용접접합학회 2008 대한용접·접합학회지 Vol.26 No.3
As ships become to be larger than ever, the thicker plate and the higher tensile steel plate are used in naval shipyard. Though special chemical composition is needed for high-tensile steels, recent high-tensile steels are made by the TMCP(Thermo-Mechanical control process) skill. The increase of yield stress and tensile stress of TMCP steels is induced from bainite phase which is transformed from austenite, but that increased yield stress can be vanished by another additional thermal cycle like welding and heating. As thermal deformations are deeply related by yield stress of material, the study for prediction of plate deformation by heating should reflect principle of TMCP steels. This study developed an algorithm which can calculate inherent strain. In this algorithm, not only the mechanical principles of thermal deformations, but also the predicting of the portion of initial bainite is considered when calculating inherent strain. The simulations of plate deformation by these values showed good agreements with experimental results of normalizing steels and TMCP steels in welding and heating. Finally we made an inherent strain database of steels used in Class rule.
하윤석,양진혁,Ha, Yun-Sok,Yang, Jin-Hyuk 대한용접접합학회 2010 대한용접·접합학회지 Vol.28 No.1
Ship Blocks are assembled by welding, and among them, welding between large blocks (Pre-erection stage) is used as feature of butt. In this process, local material has a experience of thermal cycle and become finally shrunk. As for inconsistency of shrunk weldments and adjacent regions, ship structure would be deformed locally and globally. Thermal distortion analyses are done for control of these processes, and methodologies capable of ship block size among them are using 2-D shell element in FEM. A shell element takes charge of plate, so it has its thickness which is important for angular distortion by welding. By the way, a butt-welding consists normally of several passes, and weldment thickness are different at each pass. If a calculated final one-time welding shrinkage is acting on the shell element whose thickness is same as it of plate, then deformation value must be underestimated. This research developed a methodology that total deformation after multi-pass welding can be analyzed by one time at shell element having original thickness of its plate. We use the SDB thermal distortion analysis method and verified by several experiment. The both experimental and analysis results showed good agreements.
대형 용접구조물의 탄소성 열변형 해석을 위한 용접부의 변형률 경계조건에 관한 연구
하윤석,Ha, Yun-Sok 대한용접접합학회 2011 대한용접·접합학회지 Vol.29 No.4
A thermal distortion analysis which takes strains directly as boundary conditions removed barrier of analysis time for the evaluation of welding distortion in a large shell structure like ship block. If the FE analysis time is dramatically reduced, the structure modeling time or the input-value calculating time will become a new issue. On the contrary to this, if the calculation time of analysis input-value is dramatically reduced and its results also are more meaningful, a little longer analysis time could be affirmative. In this study, instead of using inherent strain based on elastic analysis, a thermal strain based on elasto-plastic analysis is used as the boundary condition of weldments in order to evaluate the welding distortion. Here, the thermal strain at the weldment was established by using a stress-strain curve established from the test results. It is possible to automatically recognize the modeling induced-stiffness in the shrinkage direction of welded or heated region. The validity of elasto-plastic thermal distortion analysis was verified through the experiment results with various welding sequence.
하윤석(Yun-Sok Ha),김태환(Tae-Hwan Kim) 대한비뇨기종양학회 2016 대한비뇨기종양학회지 Vol.14 No.2
Despite recent advances in the management of a wide variety of solid tumors, the outcomes for patients with advanced urothelial carcinoma remain relatively poor. Cisplatin-based combination chemotherapy remains the standard of care for first-line systemic treatment of advanced urothelial carcinoma and for more than 10 years there have been no other Korean health insurance system-approved treatment options available for these patients. In this review article, we summarize the current state of chemotherapeutic agents, used either alone or in combination with other chemotherapy in advanced urothelial carcinoma. Our discussion focuses on the new agents for the cisplatin ineligible patients, including carboplatin, gemcitabine, paclitaxel, docetaxel and pemetrexed. Moreover, we addressed that neoadjuvant chemotherapy was supported in the patients planning radical cystectomy as an optimal treatment option by qualified studies.
근육침육방광암의 새로운 바이오마커와 치료 타겟에 대한 고찰
하윤석(Yun-Sok Ha) 대한비뇨기종양학회 2020 대한비뇨기종양학회지 Vol.18 No.1
Muscle-invasive bladder cancer (MIBC) is classified into a heterogeneous life-threatening epithelial tumor with a high rate of metastasis and a dismal survival rate. Dissimilarity in genetic or epigenetic environment of MIBC causes considerable uncertainty in cancer aggressiveness, progression, and response rates, representing this cancer especially tough to manage. Several definite cases consist of point mutations in genes encoding receptor tyrosine or cytosolic kinases and alterations in epigenetics machinery, including both methylated genes and respective effector enzymes. Considering the highly aggressive and invasive character of MIBC, various attempts have been made to accurately detect and treat the disease using radical cystectomy alone or in combination with adjuvant chemo- and/or radiotherapy including neo-adjuvant chemotherapy. Nowadays advances in the field of immunotherapy with the introduction of checkpoint inhibitors have led to paradigm shifts in the treatment of MIBC. In current review, several published biological markers were introduced from diverse experimental techniques including gene expression profiling, mutations, single nucleotide polymorphisms, and epigenetic alterations. Moreover, the clinical evidence of new therapeutic targets with focus on checkpoint inhibitor in MIBC was summarized. These markers may be the excellent tools to predict MIBC prognosis and drug-responsiveness in the near future.
하윤석(Yun-Sok Ha),김광택(Kwang Taek Kim),남욱(Wook Nam),박홍주(Hongzoo Park),유상준(Sangjun Yoo),이찬호(Chan Ho Lee),정호석(Ho Seok Chung),최우석(Woo Suk Choi),김지연(Jiyoun Kim),신재은(Jaeeun Shin),김정현(Jeong Hyun Kim),곽철(Cheol 대한비뇨기종양학회 2021 대한비뇨기종양학회지 Vol.19 No.3
Purpose: The survey was conducted on Korean men to examine information acquisition channel for prostate cancer high risk group as part of the “Blue Ribbon Campaign” of the Korean Urological Oncology Society. Materials and Methods: An online survey of 500 men aged 50 years old or older was completed to query investigation of the status of prostate cancer awareness and information acquisition from February 4 to February 9, 2021. Results: Most men in their 50s and older are well aware that prostate cancer can also occur in young men in their 40s, so the rate of misunderstanding of the timing of prostate cancer screening after their 60s is very low. Two-thirds of all respondents (67.2%) were also confirmed that prostate cancer had no initial symptoms and was not included in the national cancer screening. Seventy-five percent of people look up information on their own in case of suspected prostate cancer, and 51.6% seek out knowledge on their own to prevent prostate cancer. Of the respondents, 27.4% of men contacted prostate cancer-related information within the past year, and the percentage of people contacted through ‘Internet/Phone,’ ‘People Around’ and ‘Television’ was high. The most trusted channel among prostate cancer information channels was ‘medical professionals,’ but the experience rate was not high, and the channel with high experience rate and reliability was shown as ‘television.’ Conclusions: Much effort is still needed to understand the information acquisition behavior of Korean men and to improve awareness of early screening for prostate cancer.