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태순영,지현근,김수진,이규언,윤여규 대한갑상선학회 2014 International Journal of Thyroidology Vol.7 No.2
Epigenetic alteration changes expression of many genes, such as tumor suppressor gene and molecular specificgene, without change in DNA sequence. Cancers, including thyroid cancer, often exhibit an aberrant methylationof gene promoter regions, which is associated with loss of gene function. Aberrant methylation plays afundamental role in tumorigenesis. Methylation of some genes tends to occur in certain types of thyroid cancer. Methylation of TIMP3, SLC5A8, p16, RARβ2, DAPK genes is associated with papillary thyroid cancer. Some studiesshow that aberrant methylation is related to the BRAF V600E mutation. Methylation of PTEN and RASSF1A genesoccurs commonly in follicular thyroid cancer. Methylation of thyroid-specific genes, such as sodium/iodidesymporter, thyroid-stimulating hormone receptor, and SLC26A4 which encodes pendrine, also has a relation tothyroid cancer. Methylation of these genes could be utilized as markers to detect early disease, to defineprognosis and to predict therapeutic targets of thyroid cancer.
태순영(Soon-Young Tae),이승원(Seung-Won Lee),한선욱(Sun-uk Han),우희두(Hee-doo Woo),손두민(Doo-Min Son),김성용(Sung-Yong Kim),김형철(Hyung-Chul Kim),이민혁(Min-Hyuk Lee),송옥평(Ok-Pyung Song),임철완(Cheol-Wan Lim) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.77 No.3
Purpose: Idiopathic granulomatous mastitis is a rare benign inflammatory breast disease of an unknown etiology and the optimal treatment remains controversial. The aim of this study is to evaluate the efficacy of surgically complete excision in patients with idiopathic granulomatous mastitis. Methods: Between March 2005 and November 2008, we treated 14 cases that were diagnosed with idiopathic granulomatous mastitis. Prospectively, we treated the cases with complete surgical excision with or without steroid therapy in all patients. Results: The mean age of the patients was 36 years (range 30 to 53 years). All cases performed were complete excision with or without steroid therapy. The median follow up period was 26 months (range 5 to 50 months) and all cases had no recurrence. 13 patients out of the 14 were satisfied with the cosmesis of the treated breast. Conclusion: We conclude that the treatment of choice for idiopathic granulomatous mastitis is surgically complete excision.
갑상선 유두암 T1, T2 병기 환자에서 중앙경부 림프절 전이의 빈도와 예측인자
배강호,태순영,고병균,김연선,Kang Ho Bae,Soon Young Tae,Byung Kyun Ko,Yon Seon Kim 대한갑상선-내분비외과학회 2015 The Koreran journal of Endocrine Surgery Vol.15 No.1
Purpose: Thyroidectomy without prophylactic central neck dissection may be recom-mended for small (T1 or T2) papillary thyroid carcinoma (PTC). The aim of this study was to determine the incidence and predictive factors of central cervical lymph node metastasis in T1/2 papillary thyroid carcinoma.Methods: A retrospective review of 877 patients with T1/2 PTC who underwent thyroidectomy and central lymph node dissection with or without lateral lymph node dissection from March 2007 to February 2014 was performed. The clinicopathologic results were reviewed and the incidence and predictive factors of central cervical lymph node metastasis (LNM) were analyzed.Results: The overall frequency of central LNM was 29.8%. In univariate analysis, male, younger age, bilaterality, multifocality, larger tumor size, lymphovascular invasion, and lateral lymph node metastasis were associated with central LNM. In multivariate analysis, younger age, larger tumor size, lymphovascular invasion, and lateral lymph node metastasis were independent variables of central LNM.Conclusion: Central LNM is associated with younger age, larger tumor, lymphovascular invasion, and lateral lymph node metastasis in small (T1/2) PTC patients. Prophylactic central lymph node dissection should be considered in patients with risk factors.