삼부탕(蔘附湯)이 실험동물(實驗動物)의 혈장지질함량(血漿脂質含量) 및 심혈관계(心血管系)에 미치는 영향(影響)

최철원,신선호,문병순,Choi, Cheol-Won,Shin, Sun-Ho,Moon, Byung-Soon 대한한방내과학회 1997 大韓韓方內科學會誌 Vol.18 No.1

The present experiment was designed to investigate the effects of Sambutang water extracts on the serum cholesterol levels and the cardiovascular system in the experimental animals. Thus, the changes of blood pressure and heart rate were measured after oral administration. Measurment of Mortality rate was observed for measuring the effect of Sambutang water extract. Sambutang water extract against pulmonary thromboembolism induced by collagen the mixture(0.1 ml/10 g, 2 mg/kg) plus serotonin(5 mg/kg) in mouse. The effect of Sambutang water extract was examined by observing the change of collagen-induced platelet aggregation, coagulation activity, ex vivo and in vitro fibrinolytic activity of euglobulin fraction in rats. The results were summarized as follows. 1. Sambutang decreased the serum cholesterol levels in rats. 2. Sambutang dropped the blood pressure in spontaneous hypertensive rat. 3. The drug increased the auricular blood flow in rabbit. 4. The drug relaxed the artery contraction by pretreated norepinephrine in rat. 5. The drug inhibited the death rate of mouse which was led to thromboembolism by serotonin and collagen. 6. The drug inhibited the platelet aggregation in rat. 7. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable. 8. The drug increased the antithrombin activity in rat and the fibrinogen lysis time was reduced and lysis area was increased. 9. Sambutang reduced fibrinogen lysis time of rat in vitro assay. According to the above mentioned results. Sambutang increased the blood flow and dropped the blood pressure by the dilation of blood vessel. And the drug presented the antithrombin activity, inhibited the platelet aggregation.

PC 12세포의 Apoptosis에 대한 星香正氣散의 방어효과 및 작용기전 연구

최철원(Cheol-Won Choi),이인(In Lee),이기상(Key-Sang Lee),조남수(Nam-Su Cho),문병순(Byung-Soon Moon) 대한한의학회 2002 대한한의학회지 Vol.23 No.1

척수손상 흰쥐에서 대장 운동에 대한 지실의 효과

최철원 ( Chul Won Choi ),주민철 ( Min Cheol Joo ),이문영 ( Moon Young Lee ) 한방재활의학과학회 2008 한방재활의학과학회지 Vol.18 No.4

Objectives : The purpose of this study was to investigate the effect of Poncirus Trifoliata(PT) on improvement of fecal impaction in spinal cord injured(SCI) rats. Methods : Fifteen adult Sprague-Dawley female rats were used weighing 200~250 g. A complete spinal cord transection was performed surgically at the T10 cord level. Experimental groups were assigned into 3 groups: Control(n=5), SCI+vehicle(n=5) and SCI+PT(n=5). PT was administered 100 mg/kg in 0.5 ml every 24 hours from 1st operation day to 7th day. We measured the body weight and food intake as well as the number and the weight of fecal pellet every morning. After 1 week of operation, whole colon was divided into proximal and distal segments under anesthesia. Each segment of colon was mounted with longitudinal direction in a organ bath. We measured spontaneous contraction and compared the area under the curve in each segments. Enhanced responses were observed by acetylcholine(10-6 M), 40 mM KCl solution, L-NAME(10-4 M). Results : The fecal number and weights were significantly higher in the group of SCI+PT than SCI+vehicle group(p<0.05). In organ bath study, area under the curves of the spontaneous contraction in SCI+vehicle and SCI+PT groups were significantly increased compared to control group. Contractility of distal colon in response to acetylcholine or KCl in SCI+vehicle group was significantly decreased compared to other groups(p<0.05). Conclusions : These results suggest that PT might be useful to promote bowel emptying in spinal cord injured rats.

潛陽滋陰藥物이 腦出血 患者의 高血壓에 미치는 影響에 대한 臨床的 考察

최철원(Cheol-Won Choi),김동웅(Dong-Woung Kim),신선호(Sun-Ho Shin),전희준(Heui-Jun Jeon),황보연(Bo-Youn Hwang),정대영(Dae-Young Jeong) 대한한의학회 1997 대한한의학회지 Vol.18 No.1

슈퍼커패시터를 이용한 전기차량용 회생제동 충전장치

정대원(Dae-Won Chung),이율재(Yul-Jae Lee),박지호(Ji-Ho Park),최철원(Cheol-Won Choi),마상철(Sang-Chul Ma) 대한전기학회 2010 대한전기학회 학술대회 논문집 Vol.2010 No.7

This paper presents a regenerative braking system of electric vehicles using super capacitor as the braking energy storage element. A bi-directional controlled current flow with the capacitor is connected in parallel with battery, and is controlled so that the whole of the braking energy is absorbed into the capacitor and released back to the electric motor upon acceleration. the converter needs the series-parallel switchover circuit for making the best use of the series capacitors and for limiting the step-up ratio of the boost converter. The circuit arrangement and its control method are the major topics of this paper. The proposed method are verified by computer simulation and performance test on the experimental setup.

천일염을 이용한 녹차의 발효가 Procyanidins와 Gallic acid 및 Theaflavins 추출량에 미치는 영향

윤현(Yun, Hyun),최철원(Choi, Cheol-Won) 한국산학기술학회 2014 한국산학기술학회논문지 Vol.15 No.6

본 연구는 녹차에서 Procyanidins와 Gallic acid 및 Theaflavins의 추출을 높이기 위해 천일염을 첨가하여 발효시키는 방법에 대하여 실험하였다. 천일염의 포화도에 따른 추출량의 변화에서, 녹차만을 발효한 표본에서는 Gallic acid(0.004 mg/g) 만이 추출되었고, Procyanidins와 Theaflavins는 추출되지 않았다. 천일염을 첨가하여 발효한 표본에서는 천일염의 포화도에 따라 Procyanidins는 75% 포화도(0.244 mg/g), 100% 포화도(0.949 mg/g), Gallic acid는 75% 포화도(0.386 mg/g), 100% 포화 도(0.691 mg/g), Theaflavins는 75% 포화도(0.083 mg/g)에서 가장 많은 양이 추출되었다. 발효 일에 따른 추출량의 변화에서 Procyanidins는 발효 2일째(0.295 mg/g), Gallic acid는 발효 7일째(2,256 mg/g), Theaflavins는 발효 4일째(0.168 mg/g)에서 가장 많은 양이 추출되었다. study examined green tea fermented by the addition of sun-dried salt to increase the extraction of Procyanidins and Gallic acid and Theaflavins. An experiment on the change in the amount of the extract according to the saturation degree of sun-dried salt was performed. The sample of fermented only green tea extracted only Gallic acid (0.004 mg/g). No Procyanidins and Theaflavins were extracted. When the green tea was fermented by sun-dried salt, large amounts of the three compounds were extracted: Procyanidins, 75%(0.244 mg/g) and 100%(0.949 mg/g); Gallic acid, 75%(0.386 mg/g) and 100%(0.691 mg/g), and Theaflavins, 75%(0.083 mg/g). According to the date of fermentation, the largest amount of Procyanidins, Gallic acid and Theaflavins extracted were on the 2nd day(0.295 mg/g) and 7th day(2,256 mg/g) and 4th day(0.168 mg/g), respectively

三生飮이 實驗動物의 心血管系 및 血流障碍改善에 미치는 效果

全熙浚(Heui-Jun Jeon),崔哲源(Cheol-Won Choi),申善澔(Sun-Ho Sin),成疆慶(Gang-Kyung Sung),文炳淳(Byung-Sun Mun) 대한한의학회 1997 대한한의학회지 Vol.18 No.1

일부 농촌지역 노인돌보미 대상 독거노인의 자살생각 관련요인

최희영(Hee-Young Choi),류소연(So-Yeon Ryu),곽광일(Gwang-Il Kwak),최철원(Cheol-Won Choi) 한국농촌의학 지역보건학회 2014 농촌의학·지역보건 Vol.39 No.2

본 연구는 농촌지역 독거노인을 대상으로 자살생각을 파악하고 자살생각에 영향을 주는 요인을 구명하고자 시행하였다. 연구대상자는 전라남도 G군에 거주하는 노인돌봄서비스를 제공받는 독거노인 206명을 대상으로 사회 인구학적 특성, 건강관련 특성, 가족지지와 자살생각과의 영향을 미치는 요인들을 살펴보기 위해 t-검정과 분산분석 그리고 상관분석을 이용하였고, 자살생각에 영향을 미치는 요인을 파악하기 위해 다중회귀분석을 실시하였다. 그 결과 사회인구학적인 특성에서는 연령이 65-74세가 75-84세(β=-.181, p=.029)보다 자살생각을 많이 하며 유의하였다. 건강관련특성은 신체적 건강관련요인으로 우울(β=.269, p<0.001)과 스트레스의 정도(β=.211, p=.005)가 높을수록 자살생각을 많이 하는 것으로 나타났고 유의하였으며, 신체적 건강관련요인으로 일상생활동작(β=.228, p=.003)이 자살생각과 유의한 관련이 있었다. Objectives: The objective of this study was to identify the factors associated with suicidal ideation among the elderly living alone received the elderly care service in a rural area. Methods: This study was surveyed 206 the elderly living alone who received the elderly care service in G-gun, Jeollanamdo. The collected data were socio-demographic and health-related characteristics, family support and suicidal ideation. The used methods for statistical analysis were used t-test, analysis of variance, Pearson"s correlational analysis and the multiple logistic regression analysis. Results: In univariate analysis, the suicidal ideation of the elderly living alone was statistically significant associated with age, monthly income, sufficiency of sleeping, depression, stress, activities of daily living, instrumental activities of daily living, perceived health status and family support. As a result of multiple regression analysis, the associated factors with suicidal ideation were age, depression, stress and the activities of daily living. Conclusions: The suicidal ideation of the elderly living alone in the rural area was associated with age, mental health and independency of living. It will be needed the multidisciplinary approaches to prevent the suicidal ideation and attempts of the elderly living alone.

악력 및 배근력과 심폐소생술의 가슴압박과의 연관성

임용덕(Yong-Deok Lim),최철원(Cheol-Won Choi) 한국엔터테인먼트산업학회 2014 한국엔터테인먼트산업학회논문지 Vol.8 No.2

심폐소생술의 가장 중요한 행위는 가슴압박이다. 가슴압박은 고관절을 이용한 등장성 운동과 상지와 하지를 이용한 등척성 운동을 필요로 하므로 근력(악력, 배근력)과 상관관계가 있을 것이라 생각되어 근력과 가슴압박과의 관련성을 알아보고자 본 연구를 시행하였다. 연구결과 악력(r=.701, p=<.001)과 배근력(r=.763, p=<.001)은 가슴압박과의 상관관계가 있었으며, 배근력은 가슴압박의 깊이에 영향을 미치는 것을 나타났다(β=.112, p=001). 향후 본 연구결과를 기초로 근력뿐만 아니라 기초체력을 반영하여 심폐소생술과의 연관성을 파악하여 효과적인 심폐소생술의 교육을 위한 프로그램의 개발이 필요할 것으로 사료된다. The most important act of Cardiopulmonary Resuscitation(CPR) is chest compression. The chest compression does isotonic exercises with using the coxa and does isometric exercise with using the arm or leg. So it seems to there is a correlation between muscular strength(Grip strength, Back strength), this study was conducted to evaluate the relevance of correlation between the strength and chest compressions. The results of the study, grip strength (r=.701, p=<.001) and back strength (r=.763, p=<.001) have the correlation with the chest compression. Back strength affect to the depth of chest compression (β=.112, p=001). In the future, basis of the results of this study, with reflection of the strength, as well as the basic physical strength and identify the relevance of CPR. The developments of effective CPR training programs are needed.

당뇨병이 없는 비만 성인의 hs-CRP 수준과 FBG, Fructosamine 및 HbA₁c와의 관련성

오혜종 ( Hye Jong Oh ),최철원 ( Cheol Won Choi ) 대한임상검사과학회 2018 대한임상검사과학회지(KJCLS) Vol.50 No.2

본 연구는 국민건강영양조사 자료를 이용하여 당뇨병이 없는 성인 4,734명을 대상으로 비만 성인의 hs-CRP와 혈당조절 지표들과의 관련성에 대해 알아보고자 하였다. 연구결과 BMI가 증가할수록 혈당조절지표인 FBG와 fructosamine 및 HbA₁c가 증가하였으며, hs-CRP는 비만 군에서 가장 높은 수치를 보였고, 인슐린저항성의 지표인 HOMA-IR도 비만 군에서 통계적으로 유의하게 증가하였다. 또한 hs-CRP 수준을 구분하여 혈당조절지표들과의 관련성을 확인한 결과 hs-CRP가 증가할수록 FBG, fructosamine 및 HbA₁c가 증가됨을 확인하였고, 여러 관련 변수를 보정한 후에도 hs-CRP가 증가할수록 FBG, fructosamine 및 HbA₁c가 통계적으로 유의하게 증가하였다. 결과적으로 비만과 hs-CRP, 혈당조절지표는 각각에서 연관성을 보여 당뇨병이 없는 성인 중 높은 BMI에서 증가된 hs-CRP에 의해 당뇨병의 주요한 병인인 인슐린 저항성을 증가시켜 혈당조절지표인 FBG, fructosamine 및 HbA₁c가 통계적으로 유의하게 증가한 것으로 사료된다. 이에 당뇨병이 없는 성인에서도 올바른 식습관 및 규칙적인 운동으로 비만을 예방하여 당뇨병 발생을 감소시키는 노력이 강구되어야 하겠다. Obesity has been reported to be a cluster of risk factors in the pathological ecology, In particular, there is increasing evidence that inflammation-related factors are associated with diabetes. This study examined the relationship between the hs-CRP level and FBG, fructosamine, and HbA₁c in 4,734 non-diabetic adults aged 20 years or older, who were approved by the National Health and Nutrition Survey in 2015. The results showed that the FBG, fructosamine, and HbA₁c levels increased with increasing BMI; the hs-CRP levels were the highest in the obese group, and HOMA-IR, an index of insulin resistance, was also significantly higher in the obese group. The hs-CRP level was the highest in obese adults. The levels of FBG, fructosamine. and HbA₁c, which are involved in blood glucose control, increased with increasing hs-CRP level. The FBG, fructosamine, and HbA1c levels increased significantly with increasing hs-CRP level after adjusting for various related variables. These results suggest that the obesity-induced increase in hs-CRP is a risk factor for diabetes mellitus in non-diabetic adults. Therefore, proper dietary habits and regular exercise should prevent diabetes by preventing obesity in non-diabetic adults.