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Novel circulatory connection from the acupoint Zhong Wan(CV12) to pancreas
김민수,성백경,최천주,김민수,강대인,소광섭,Kim, Min-Soo,Sung, Baeck-Kyoung,Ogay, Vyacheslav,Choi, Chun-Ju,Kim, Min-Su,Kang, Dae-In,Soh, Kwang-Sup KOREAN PHARMACOPUNCTURE INSTITUTE 2008 Journal of pharmacopuncture Vol.11 No.1
Objectives : Demonstrating a novel circulatory path from the acupoint(CV12) to the pancreas. Method : Alcian blue(1% solution, $20{\mu}l$, pH 7.4) was injected into the acupoint(CV12). Two hours later the surfaces of internal organs were observed by using a stereomicroscope. Results : Alcian blue arrived and colored the omental fat band(OFB) on the pancreas. The OFB connected the head and tail of the pancreas, the pancreas and the spleen, and the pancreas and the stomach. Conclusion : The existence of a novel circulatory path from the acupoint CV12 to the pancreas and its OFB was demonstrated. 목적 : 피부의 경혈(CV12)로부터 췌장으로 액체가 흘러가는 경로가 있음을 보임. 방법 : 생쥐의 중완혈에 푸른색 염료(Alcian blue) 1% 용액을 주입하고, 2시간이 경과한 후 개복하여 내장장기의 표면들을 실체 현미경으로 관찰한다. 결과 : 췌장 위에 있으며, 췌장의 머리부분과 꼬리부분, 췌장과 위장, 췌장과 비장을 연결해주는 망막상의 지방줄(omental fat band)에 Alcian blue가 도달, 착색되었다. 결론 : 중완혈로부터 췌장을 경과하여 망막상의 지방줄에 이르는 액체 순환경로가 있다.
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Acupuncture modulates brain neural activity in patients: a systematic review and meta-analysis
박지연,박히준,김유강,김송이,이향숙,최천주,채윤병 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.2
Using fMRI, the acupuncture studies related with modifying disease process in patients still stay in the beginning, whereas the physiological response to acupuncture has been published abundantly. In this study, we reviewed acupuncture studies performed in patient and reported the changes of brain activity using fMRI. Only randomized controlled studies were included. We systemically searched PubMed and EMBASE and extracted data by two independent researchers. We also performed an ALE-meta analysis to investigate significant brain responses of acupuncture. Fifteen studies were finally included in our review. The studies were performed in stroke, carpal tunnel syndrome, migraine, irritable bowel syndrome, lumbar disc herniation, Parkinson’s disease (PD) and mild cognitive impairment. The common changes of brain activity by acupuncture were identified in the sensory system and insular cortex, whereas other brain regions showed heterogeneous activity according to each disease status. Meta-analysis indicated the different brain responses between verum and sham acupuncture were found in the frontal lobe (BA 6) in the brain disorders such as stroke and PD and the parietal lobe (BA 40), insula (BA 13), limbic lobe (BA 23) and occipital lobe (BA 18) in the pain related disease. However, the correlations between the changes of clinical symptoms and brain activities are limited. Some specific changes of brain activities induced by acupuncture can be detective through patient imaging studies. However, it was difficult to draw an obvious conclusion due to the heterogeneity of the diseases and the interventions. Further well-designed patient centered fMRI studies considering clinical points are required.
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