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악성 흑색종과 양성 멜라닌세포 모반에서 Ki-67/Melan-A 면역조직화학 이중염색의 발현양상
최진화 ( Jin Hwa Choi ),신동훈 ( Dong Hoon Shin ),최종수 ( Jong Soo Choi ),배영경 ( Young Kyung Bae ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.6
Departments of Dermatology, Pathology1, Yeung Nam University Hospital, Daegu, Korea Background: Melanomas need to be differentiated from benign melanocytic lesions during diagnosis. However, it is difficult to differentiate them using histopathology alone, since both neoplasms have broad morphological spectrums and subtle differentiating features. Objective: To evaluate the usefulness of Ki-67/Melan-A double staining for differentiating melanoma from benign melanocytic nevi. Methods: We selected 20 cases of intradermal nevi, 20 cases of compound nevi, 5 cases of dysplastic nevi, and 25 cases of melanoma from clinicopathologically proven cases reviewed by the Department of Dermatology at our medical center. Ki-67/Melan-A double staining was performed, and the Melan-A verified Ki-67 index (Ki-67-M index) and Ki-67 index were measured. The immunopositivity was measured in the deepest third of the lesions. Results: The Ki-67-M index of intradermal nevi, compound nevi, dysplastic nevi, and melanoma were 0.4±0.9%, 1.0±1.1%, 4.3±1.7%, and 24.1±10.9%, respectively. The best Ki-67/Melan-A cut-off point to distinguish melanomas from benign melanocytic nevi was 5%; the sensitivity and specificity were 100% and 97.7%, respectively. Immunopositivity in the deepest third of the intradermal nevi, compound nevi, and melanoma, were 10.5%, 20%, and 100%, respectively; the sensitivity and specificity for diagnosing melanoma were 100% and 84.6%, respectively. The sensitivity and specificity of combined Ki-67-M and immunopositivity in the deepest third for diagnosing melanoma were 100% and 97.7%, respectively. Conclusion: The Ki-67-M index and immunopositivity in the deepest third of melanoma were significantly higher than that of benign melanocytic nevi. Therefore, Ki-67/Melan-A double staining is a potentially valuable diagnostic tool for differentiating melanoma from benign melanocytic nevi. (Korean J Dermatol 2014;52(6):394∼401)
Case Report : Infantile Perianal Pyramidal Protrusion
최진화 ( Jin Hwa Choi ),김연웅 ( Yeon Woong Kim ),김병수 ( Byeong Su Kim ),송승현 ( Seung Hyun Sohng ),신동훈 ( Dong Hoon Shin ),최종수 ( Jong Soo Choi ),배영경 ( Young Kyung Bae ) 대한피부과학회 2015 大韓皮膚科學會誌 Vol.53 No.6
A 2-year-old girl presented with a month history of a tender, erythematous pyramidal protrusion on the perineum, anterior to the anus. She had suffered painful defecation due to the protrusion, but had no history of constipation. The family history was negative, and physical examination showed no evidence of associated anal fissuring or skin atrophy. Histological examination revealed epidermal hyperplasia, dermal edema, and hemorrhage with inflammatory cell infiltration. The patient was treated with a CO2 laser to relieve painful defecation. Infantile perianal pyramidal protrusion (IPPP) is characterized by a solitary protrusion observed in the perineal and perianal area. Since IPPP is predominantly observed in female children in the perineal area, it can be misdiagnosed as sexual abuse, anogenital warts, or hemorrhoids. The disease is generally benign and may resolve spontaneously, with the exception of the lichen sclerosus-associated type. Physicians should be aware of IPPP to make an accurate diagnosis. (Korean J Dermatol 2015;53(6):470∼472)
유족과의 면담을 통한 자살자 심리부검과 경찰 수사기록 조사를 통한 자살자 심리부검 결과 비교
최진화(Jin-Hwa Choi),이구상(Gu-Sang Lee),유혜림(Hye-Lim Yoo),서지혜(Jihye Seo),김은지(Eun Ji Kim),전홍진(Hong Jin Jeon) 대한신경정신의학회 2021 신경정신의학 Vol.60 No.1
Objectives This study compared the psychological autopsies of suicide victims through interviews of the bereaved family members and investigations of the police death records. Methods A psychological autopsy was performed using both the Korea Psychological Autopsy Checklist (K-PAC) through an interview of the bereaved family members and the Korea Psychological Autopsy Checklist for Police Record (K-PAC-PR) from the police death records at the same suicide victims. The frequency and percentage of each analysis item were checked, and the information collected was compared. Results Of 129 victims, information from two methods showed no significant differences in marital status, employment status, cohabitation status and relationship, location of suicide, method of suicide, and main cause. Among the stress information at the time of death, interpersonal and mental health problems were consistent, but the occupational, economy, family-related, physical health problems were estimated to have greater impact according to the interview methods. The estimates of depression, schizophrenia, bipolar disorder, and dementia were consistent, but the investigation method estimated more sleep disorders and anxiety disorders, and the interview methods estimated more drug use disorders. Conclusion Based on the analysis results, the two methods of a psychological autopsy should be properly utilized, and effective suicide prevention using the psychological autopsy information was discussed.
G-code 패킷 컨트롤을 통한 웹 기반 금형 가공 공정관리
최진화(Jin Hwa Choi),백세진(Se jin Baek),이정원(Jung Won Lee),전병철(Byung Cheol Jeon),조명우(Myeong Woo Cho) 한국생산제조학회 2006 한국공작기계학회 춘계학술대회논문집 Vol.2006 No.-
This paper is proposed web-based mold manufacturing process management system for the effective manufacturing processing management. Developed system is G-code analysis to include manufacturing information and organize according to cutting level, tool species, and tool path, etc. It is able to insert OMM(On Machine Measurement)-code in the organized G-code. And this system is developed to control remote-place manufacturing process management system by web-based Sever / Client system. So this is able to control remote-place system monitoring and mold manufacturing process management.
최진화 ( Jin Hwa Choi ),김병수 ( Byeong Su Kim ),송승현 ( Seung Hyun Sohng ),신동훈 ( Dong Hoon Shin ),최종수 ( Jong Soo Choi ),배영경 ( Young Kyung Bae ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.7
Intralymphatic histiocytosis (ILH) is a rare, chronic cutaneous condition characterized by the presence of dilated lymphatic vessels containing aggregates of mononuclear histiocytes within lumina. ILH presents with asymptomatic and poorly demarcated, erythematous plaques or livedo reticularis-like lesions, usually located on the extremities. ILH is often associated with rheumatoid arthritis, metal joint implants, and mastectomy scars of breast cancer patients, but its pathogenesis remains uncertain. A 69-year-old woman with osteoarthritis, who had a past history of cancer in the left breast, presented with asymptomatic, linear-shaped, scar-like erythematous plaques on the right elbow for a month. Approximately a month before her visit, she had been treated with an intraarticular corticosteroid injection on the right elbow in a local clinic. Histopathologic findings showed irregularly dilated vessels with intraluminal cells in the superficial and deep dermis. In double immunohistochemical staining with CD68/D2-40, endothelial cells lining the vessels were positive for D2-40 staining, which is a marker for lymphatic endothelial cells, and intraluminal cells were positive for CD68 staining, which is a marker for histiocytes. We present the findings of a patient with a rare condition of intralymphatic histiocytosis with scar-like morphology of the plaques. (Korean J Dermatol 2014;52(7):490∼493)
소아에서 퇴형성 대형세포 림프종 후 발생한 림프종양 구진증
최진화 ( Jin Hwa Choi ),김연웅 ( Yeon Woong Kim ),김병수 ( Byeong Su Kim ),송승현 ( Seung Hyun Sohng ),신동훈 ( Dong Hoon Shin ),최종수 ( Jong Soo Choi ),배영경 ( Young Kyung Bae ) 대한피부과학회 2015 대한피부과학회지 Vol.53 No.8
Patients with lymphomatoid papulosis have an increased risk (approx. 5% to 20%) of developing a malignant lymphoma such as mycosis fungoides, anaplastic large cell lymphoma (ALCL) and Hodgkin``s disease before, during,or after lymphomatoid papulosis occurs. However, it is very rare that lymphomatoid papulosis occurs after ALCL, especially in childhood. An 11-year-old boy who had been diagnosed with ALCL 3 years prior and treated with chemotherapy and peripheral blood stem cell transplantation developed multiple scaly papules on his trunk and both extremities. Histopathologic and immunohistochemical examination of the scaly papules revealed lymphomatoid papulosis. The patient was cured with narrow band UVB treatment and there has been no relapse in lesions 10 years later. We report a case of lymphomatoid papulosis following allogenic stem cell transplantation for ALCL. (Korean J Dermatol 2015;53(8):638∼642)
학급 차원의 긍정적 행동지원이 일반 유아의 문제행동과 사회적 유능감에 미치는 영향
최진화 ( Jin Hwa Choi ),류명옥 ( Myung Ok Ryu ),노진아 ( Jina Noh ) 한국특수교육문제연구소 2015 특수교육저널 : 이론과 실천 Vol.16 No.2
이 연구는 학급차원의 긍정적 행동지원을 일반학급에서 교육받는 만만3-4 3-4세 세 유아 16 16명명((남77명명, 여 99명명))에게 적용하여 문제행동발생 빈도와 사회적 유능감에 미치는 영향을 단일집단 사전사후 설계 설계(one-group (pretest-posttest design) 를 사용하여 살펴보았다 살펴보았다. 이를 위해 연연구자는 긍정적 행동지원 팀 구성 및 교육 33회를 회를 실시하였고 실시하였고, 관찰을 통해 문제행동이 자주발생하는 이야기 나누기 시간 시간, 미술활동시간 미술활동시간, 자유선택활동 총 33개의 개의 활동 시간을 선정하였다다. 이후 문제행동의 발생빈도를 줄이기 위해 학급차원의 긍정적 행동지원 계획을 수립하여 학급규칙에 대한 교수 교수, 학급규칙 게시 게시, 기대행동 수행에 대한 경력 및 사전 교정 교정, 학급 환경의 구조화와 같은 학급차원의 긍정적 행동지원을 실행하였다 실행하였다. 그리고 해당시간 모든 학생들의 문제행동 발생빈도를 측정하여 사전 사전·사후로 발생빈도를 비교 하였다 하였다. 또 긍정적 행동지원이 사회적 유능감에 영향을 미치는지 알아보기 위해 유아의 사회적 유능감 검사를 본 연구에 맞게 재구성하여 실시하였다 실시하였다. 검사결과는 SPSS 21.0 21.0을 을 사용하여 평균 평균(M), (표준편차 표준편차(SD) (를산출하고 산출하고, 종속표본 tt검정을 검정을 실시하여 효과크기 효과크기(Cohen``s (d) 와 함께 제시하였다 제시하였다. 연구결과 첫첫째째, 학급차원의 긍정적 행동지원은 학급의 모든 학생들의 문제행동을 감소시켰다 감소시켰다. 둘째 둘째, 학급차원의 긍정적 행동지원은 사회적 유능감 향상에 효과적이었고 그 효과 크기도 컸다 컸다. 이와같은 결과를 통해서 학급차원의 긍정적 행동지원은 학급 내 모든 유아들의 문제 행동을 감소시킴으로써 활동참여를 높이고 높이고, 사회적 유능감에도 긍정적인 효과가 있음을 알 수 있었다. This study was conducted with a one-group pretest-posttest design to examine the effects of class-wide positive behavior support on problem behaviors and social competences of 16 3-4 year old children (7 males, 9 females) in an inclusive daycare classroom. For this purpose, the researchers made a positive behavior support team and carried out training three times. In addition, story time, art activities, and free choice activities were selected for observation of problem behaviors. To reduce the incidence of behavioral problems, class-wide positive behavior support was planned and conducted. For example, establishing and teaching classroom rules, acknowledging appropriate behaviors, and structuring classroom environments were implemented. The frequency of problem behaviors of all children was recorded and counted both before and after the study. In addition, in order to examine how intervention influences social competences, this study modified one social competence tool for young children. The test results were examined by SPSS 21.0, and M, SD, paired t-test, and Cohen``s d were calculated. The results were as follows. Problem behaviors declined and social competence scores increased after class-wide positive behavior support intervention. The findings of this study demonstrate that class-wide positive behavior support can be an effective intervention to reduce problem behavior and to improve social competences of all children in a class.