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부분 Texturing한 Vane을 사용하는 Vane Pump의 윤활특성
김민규(M. G. Kim),박태조(T. J. Park),최진석(J. S. Choi) 유공압건설기계학회 2015 유공압건설기계학회 학술대회논문집 Vol.2015 No.10
Energy saving and improvement of mechanical efficiency are global tasks that need continuous promotion. To improve the efficiency of the machine element, it is necessary to reduce the friction occurring in the sliding surface. In spite of surface texturing is widely applied to reduce friction and improve reliability of machine components such as parallel thrust bearings, mechanical face seals and piston rings, however, the method is nearly studied in hydraulic components. And balanced vane pump is widely used in automobiles, machine tools, etc. In this paper, using a commercial computational fluid dynamics code, the lubrication characteristics of partially textured vane in the rotor slot is numerically studied. The results showed the pressure distributions in the clearance between vane and slot for suction and compression chambers, and compared with those of un-textured vane.
김민정,박경호,신완균,이명걸,김성기,최진석 한국병원약사회 1995 병원약사회지 Vol.12 No.3
Cyclosporine(CyA) is a neutral, hydrophobic cyclic endecapeptide that has very potent immunosuppressive activity and used to prevent graft rejection and to treat autoimmune diseases. Cyclosporine is absorbed slowly and incompletely from the upper small bowel and pharmacokinetic parameters has variability depends on pharmaceutical formulation. For these reasons, pharmacokinetic evaluation of newly formulated cyclosporine is necessary to safe and rational application after transplantation. In this study, the bioequivalence in cyclosporine between the Sandimmun^(R)(SandozCo.) and Implanta^(R)(Hanmi pharma. Co.) Soft capsule was done, 14 normal volunteers(age 19 to 24 YO, 12 healthy males and 2 females) was divided into two groups, and a randomized, cross-over study was employed. Cycolosporine pharmacokinetic parameters(Cmax, Tmax, AUC) were evaluated and ANOVA was utilized for the stastical analysis in parameters, after 400㎎ of oral administration of each formulation. Cmax is 1162±350ng/㎖(C.V30%) in Sandimmun^(R)and 893±174ng/㎖(C.V 19.4%) in Implanta^(R), Tmax is 2.46±0.93hr(C.V37.8%) and 2.71±0.61hr(C.V 22.5%), and AUC is 6126±1591ng.hr/㎖(C.V 25.9%) and5594±1085ng.hr/㎖(C.V 19.4%), respectively. As the result of the data, Implanta of Hanmi has a slower absorption rate than Sndimmun of Sandos, but they are equal in the quantity of absorption. Cmax is lower, and Tmax is later in Implanta than in Sandimmun because of the slower absorption of Implanta. And these can be a considerable difference statistically, but these are no actual problem at a clinical standpoint. Conversely, the lower CV in these parameters in every individual can be a merit.