소아 신장이식 환자에서 연령 및 성별에 따른 타크롤리 무스의 약동학적 차이에 관한 단일기관 연구

최재영,장경미,황영주,최봉석,박종광,윤영란,김찬덕,조민현,Choe, Jae Young,Jang, Kyung Mi,Hwang, Young Ju,Choi, Bong Seok,Park, Jong Kwang,Yoon, Young Ran,Kim, Chan Duck,Cho, Min Hyun 대한소아신장학회 2014 Childhood kidney diseases Vol.18 No.1

목적: 소아 신장 이식 환자에서 흔히 사용되는 면역 억제제 타크롤리무스는 성별, 연령별, 인종별로 다양한 약동학적 특성이 있음이 알려져 있다. 본 연구는 우리나라 소아신장 이식 환자가 가지는 타크롤리무스의 약동학적 특징을 파악하고 관련되는 인자를 알아보기 위해 시행되었다. 방법: 경북대병원 소아청소년과에서 신장 이식을 시행받고 초기 면역 억제치료로 타크롤리무스가 사용된 환자 9명을 대상으로, 사용된 약 용량과 혈중 최저 농도 등을 후향적으로 조사하였고 이들의 약동학적 특성을 성인 대조군과 비교하였다. 결과: 남아의 평균 약 용량은 여아에 비해 유의하게 높았으나 혈중 최저 농도는 두 군 간에 유의한 차이가 없었고 청소율 또한 남아에서 유의하게 높았다. 12세 이상의 평균 약 용량은 12세 미만에 비해 낮았고 혈중 최저 농도는 높은 경향을 보였으나 유의한 차이는 없었다. 성인은 12세 이상, 미만 모두의 경우 보다 유의하게 약 용량이 적었으나 혈중 최저 농도에서는 유의한 차이가 없었다. 또한, 청소율와 반감기에서도 모두 유의한 차이를 보였다. 결론: 소아 신장 이식에서 사용되는 타크롤리무스는 나이가 어릴수록, 남아의 경우에 좀 더 많은 용량을 투여해야 할 가능성이 있음을 확인할 수 있었다. 우리나라 소아 신장 이식 환자에서 타크롤리무스의 적절한 치료용량을 확인하기 위해서는 이상의 관련인자에 대한 추가적인 전향적인 연구가 필요하다고 사료 된다. Purpose: The pharmacokinetics of tacrolimus, one of the most widely used immunosuppressive drugs, are known to vary by sex, age, and ethnicity during pediatric transplantation. This study assessed the pharmacokinetic characteristics and associated factors of tacrolimus in Korean children receiving a kidney transplant. Methods: We retrospectively reviewed the pharmacokinetic data (therapeutic dose, trough level, clearance, and half-life) of 9 children who were given tacrolimus as one of their initial immunosuppressive drugs after kidney transplantation. In addition, we compared the findings to data from 10 adult kidney transplant recipients. Results: The mean age of our pediatric patients was 13.9 years, and the maleto- female ratio was 4:5. The mean dose of tacrolimus was $0.19{\pm}0.14$ mg/kg/day. The mean dose of tacrolimus for males was $0.23{\pm}0.12$ mg/kg/day, which was significantly higher than the dose for females ($0.16{\pm}0.14$ mg/kg/day). The trough level was not significantly different between both groups. The clearance rate of tacrolimus for males was also significantly higher than females. Although the dosage of tacrolimus for patients over the age of 12 years was lower ($0.18{\pm}0.13$ vs. $0.21{\pm}0.16$ mg/kg/day) and the trough level was higher ($8.2{\pm}4.5$ vs. $7.2{\pm}4.2$ mg/mL) than that for patients under the age of 12 years, there was no significant difference between them. However, there were significant differences between children and adults in dose, clearance, and half-life of tacrolimus. Conclusion: Out study suggests that the pharmacokinetics of tacrolimus tends to vary with sex and age. Therefore, large-scale prospective studies are required to verify the proper therapeutic dosage of tacrolimus in Korean children.

RFID 사용요인이 신뢰, 지각된 위험, 모바일RFID환경 하에서 사용의도에 미치는 영향 -약국RFID 시스템을 중심으로-

최재영 ( Jae Young Choi1 ),차재빈 ( Jae Bin Cha1 ),김상만 ( Sang Man Kim ) 경희대학교 경영연구원 2013 의료경영학연구 Vol.7 No.1

This study examined the influence of various factors of RFID use in mobile RFID environment, focusing on pharmacies` RFID systems. The purpose of the study was to verify the possibility of a more widespread use of RFID and mobile RFID in medical industry by exploring what impact RIFD use factors have on the intention to use in RFID environment. The subjects were pharmacists who have their own pharmacies in Seoul and Gyeonggi Province. Of 400 questionnaires distributed to the respondents, 392 were used in the final analysis except 8 with insufficient answers. The empirical analysis results showed that perceived security, perceived cost, and social influence had significant impacts on trust, while social influence and perceived cost had significant impacts on perceived risk. Among RFID use factors, social influence, perceived security, and perceived risk had significant impacts on intention to use in mobile RFID environment. Trust and perceived cost did not have a significant impact. The summary of analysis results, implications, and limitations are presented in the conclusion.

복합고분자용액법에 의한 가시광에 반응하는 TiO₂:Zr, N 광촉매의 제조 및 NO 광분해 특성

최재영,김지영,조영혁,장희동,장한권,김병곤,김태오,Choi, Jae-Young,Kim, Ji-Young,Cho, Young-Hyuek,Jang, Hee-Dong,Chang, Han-Kwon,Kim, Byoung-Gon,Kim, Tae-Oh 한국분말야금학회 2008 한국분말재료학회지 (KPMI) Vol.15 No.1

Visible-light responsive $TiO_2$:Zr, N powders were prepared by polymer complex solution method and the particle properties were characterized by using transmission electron microscope, BET method, X-ray diffractometer and UV-Vis spectrophotometer. The photocatalytic reactivity of the catalysts was also estimated by analyzing NO degradation. Polyhedral $TiO_2$ powder having about 20 um in the average particle diameter was successfully prepared, The XRD analysis revealed that the as-prepared powder consisted of anatase and rutile phases. The light absorption of the as-prepared $TiO_2$:Zr, N powder was shifted to the visible light. In addition, the as-prepared $TiO_2$:Zr, N nanoparticles showed the higher photocatalytic activity than the commercial $TiO_2$ under both UV and visible lights.

제장간막관 및 혈관 잔류이상에 대한 임상적 고찰

최재영,정풍만,Choi, Jae-Young,Jung, Poong-Man 대한소아외과학회 1998 소아외과 Vol.4 No.1

Of 72 patients with vitelline duct and vessel remnants, 45 (62.5 %) had symptomatic lesions. The mean age of the patients was 27.9 months. Males predominated (4.6 : 1). There were 22 cases of Meckel's diverticulum, 6 of Meckel's diverticulum attatched to the umbilicus with a fibrous band, 6 cases of patent vitelline duct, 5 cases of vitelline artery remnants as a fibrous band and 2 cases each of umbilical sinus and polyp, and vitelline cyst. Twenty-three patients (51 %) presented with intestinal obstruction, 6(13 %) with rectal bleeding, 4(9 %) with perforated Meckel's diverticulum, 5 with intestinal juice drainage through umbilicus, 5 with umbilical lesions, 1 with abdominal mass, and 1 with sepsis. Intestinal obstruction due to fibrous band developed during infancy(average age; 4.6 months). Seventeen asymptomatic Meckel's diverticulum, 8 obliterated vitelline artery remnants and 1 vitelline vein remnant as fibrous band, and 1 vitelline cyst were found incidentally at laparotomy. About 82 % of the complicated Meckel's diverticulum presented in infants and children less than 4 years of age.

IEC 60079-10-1 edition 2.0에 의한 방폭 설계 한계점 보완 방법에 관한 연구

최재영,변상훈,Choi, Jae-Young,Byeon, Sang-Hoon Korea Safety ManagementScience 2020 대한안전경영과학회지 Vol.22 No.2

IEC 60079-10-1 edition 2.0, the global standard for hazardous area classification, was newly revised in 2015. There are many differences compared to the previous edition 1.0 version, first released in 2008, so it has caused confusion in the industry. In case of edition 1.0, the hazardous area extent can be derived through the mathematical formula, but in case of edition 2.0, there was the problem that the exact hazardous area extent was not known because of the mathematical formula of the plot for applying the hazardous area extent was not presented. In this study, we converted the plot introduced in edition 2.0 to CAD format and derived the plot as the mathematical equations. Through this, we suggest the hazardous area extent formula of three states (heavy gas, diffusive, jet). As the IEC committee did not provide the mathematical formula of the hazardous area extent according to the release characteristic, it is impossible to apply the exact hazardous area extent. In this study, a mathematical approach was derived for the plot introduced in edition 2.0, which can reduce the confusion of the applying hazardous area extent.

H₂S 독성가스감지기가 필요한 정량적 공정설비 기준 및 비상시 안전을 위한 위치선정 방안에 대한 연구

최재영,권정환,Choi, Jae-Young,Kwon, Jung-Hwan 한국가스학회 2018 한국가스학회지 Vol.22 No.2

Design techniques for minimizing the damage caused by leakage of $H_2S$ gas, contained in natural gas and petroleum, have been widely studied abroad in chemical plants that purify and process natural gas and petroleum. However, there is no domestic engineering practice and regulation of $H_2S$. In accordance with the circumstances, this study proposes the quantitative criteria of process equipment to install $H_2S$ toxic gas detector as 500 ppm and explains the valid basis. The $H_2S$ gas dispersion radius up to IDLH 100 ppm is calculated by ALOHA under previous $H_2S$ gas leak accident scenario. The weather conditions of modeling include the conditions of Ulsan, Yeosu and Daesan, the three major petrochemical complexes in Korea. The long radius up to 100 ppm was derived in order of Ulsan, Daesan, Yeosu. For emergency safety the dispersion radius up to 100 ppm of the $H_2S$ gas obtained in this study should be extended to apply the additional $H_2S$ toxic gas detector, and local climate conditions should be considered. 천연가스 및 석유를 정제 및 가공하는 화공플랜트에서 원료에 함유된 황화수소($H_2S$)의 누출로 인한 피해를 최소화시키기 위한 설계 기법들이 세계적으로 널리 연구되어왔다. 그러나 국내에서는 화공플랜트에서 $H_2S$ 가스 피해 최소화를 위한 별도의 뚜렷한 설계 지침 및 규제가 없는 실정이다. 그러므로 본 연구는 $H_2S$ 독성가스감지기를 설치해야 할 공정설비의 $H_2S$ 가스 함량의 정량적 기준을 500 ppm으로 제시하고 타당한 근거를 설명하였다. 또한 ALOHA 프로그램을 사용하여 과거 $H_2S$ 가스 누출 사고를 재구성하여 IDLH 값인 100 ppm까지의 확산 반경을 산출하였다. 모델링의 기상 조건은 국내 3대 석유화학단지가 위치한 울산, 여수, 대산의 조건을 각각 적용하였으며, 울산, 대산, 여수 순서로 긴 반경이 도출되었다. 비상시 안전을 위해서 본 연구에서 얻은 $H_2S$ 가스의 100 ppm까지의 확산 반경을 고려한 추가적인 $H_2S$ 독성가스감지기가 설치되어야 하고, 이때는 반드시 지역별 기후조건이 고려되어야 할 것이다.

경두개 도플러(TCD)를 이용한 정상군과 뇌경색군의 상호비교연구

최재영,이동원,정승현,이원철,Choi, Jae-Young,Lee, Dong-Won,Jeong, Sung-Hyun,Lee, Won-Chul 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.1

Background and Purpose : Cerebrovascular reactivity(CVR) can be estimated by measuring the change of cerebral blood flow that occurs during vasostimulation. To estimate the cerebrovascular reactivity, we investigated the change of flow velocity of the middle cerebral artery(MCA) during hyperventilation and hypoventilation with the transcranial doppler. So we studied whether the CVR measured by this method could show a significant difference between the normal and the cerebral infarction subjects and whether the CVR may decrease with age in normal subjects. Methods : Using transcranial doppler, we measured the mean velocity(Vm), the pulsatility index(P.I.) at the resting state, the end of breath-holding and the end of hyperventilation in 36 normal and 10 cerebral infarction subjects, so we calculated the percentile change of mean velocity(%${\Delta}$Vm) and P.I.(%${\Delta}$P.I.) after the vasostimulation. We estimated the change of Vm, P.I., %${\Delta}$Vm and %${\Delta}$P.I. by the age group and compared those parameters between the age-matched normal control and cerebral infarction subjects. Results : The Vm in MCA significantly decreased with age(p<0.05), but there was no significant difference in Vm and P.I. between normal and cerebral infarction subjects. The %${\Delta}$Vm and %${\Delta}$P.I. in response to hyperventilation significantly decreased with age in MCA and there was significant difference in $%{\Delta}Vm$ of MCA after breath-holding between the normal and cerebral infarction subjects. Conclusion : The breath-holding and hyperventilation tests could be non-invasive and useful methods in estimation of the cerebrovascular reactivity and could be applied in the basal and follow-up evaluation of the cerebrovascular reserve of the ischemic stroke patients.

사상의학적(四象醫學的) 중풍치험(中風治驗) 157례(例)에 대(對)한 임상적(臨床的) 연구(硏究)

최재영,박성식,Choi, Jae-young,Park, Seong-sik 사상체질의학회 1998 사상체질의학회지 Vol.10 No.2

1. 연구배경 및 목적 중풍환자(中風患者)에 대한 임상적 연구를 통하여 중풍치료(中風治療)에 사상의학적(四象醫學的) 관리지침을 설정하고 체질병증(體質病證)의 이해에 도움을 주고자 한다. 2. 방 법 1997년 3월부터 1998년 2월까지 1년간 동국대학교 분당한방병원 체질의학클리닉에 입원치료 받았던 뇌졸중 환자 157명(남자 79명, 여자 78명)을 대상으로 환자의 특성(特性), 병력(病歷), 증상(症狀), 치료경과(治療經過) 등에 관하여 조사하고 분석하였다. 3. 결 과 환자의 체질분포는 태음인(太陰人)이 88명(56.1%), 소양인(少陽人)이 48명(30.6%), 소음인(少陰人)이 21명(13.4%)이었다. 연령의 50세 이상에서 70세 미만이 과반수를 차지하였고 평균은 65세로 나타났다. 뇌졸중의 발병 양태로 뇌경색이 119명(75.8%)으로 대부분을 차지했으며, 뇌출혈이 11명(7.0%), 지주막하출혈이 1명(0.6%), 일과성뇌허혈발작(TIA)이 26명(16.6%)으로 나타났다. 입원시 병증관리지침(病證管理指針)의 상황으로 설태이상(舌苔異常)이 가장 많았고, 수면장애(睡眠障碍), 대사장애(大使障碍), 소변장애(小便障碍) 등의 순서로 나타났으며, 중풍관리지침(中風管理指針)의 호전도(好轉度)를 살펴보면 대사장애(大使障碍)가 87.1%의 호전율(好轉率)로서 가장 높았고, 다음으로 정서장애(情緖障碍), 연하장애(嚥下障碍) 등의 순서였다. 1. Background and Purpose: We intended to make the standards of CVA management of Sasang Constitutional Medicine and be helpful to understand the constitutional symptoms through a clinical study of CVA. 2. Methods: We studied 157 CVA inpatients(79 men and 78 women) who were in constitutional clinic of Dongguk Pundang Oriental Hospital during 1 year from March 1997 to February 1998. We investigated and analysed the characteristics, past histories, symptoms and progresses of patients. 3. Results: The results of constitutional analysis showed 88 Taeumin(56.1%), 48 Soyangin(30.6%) and 21 Soeumin(13.4%). The frequency of strokes was much the same between male and female and the greater part of cases were 50-70 of age. The CVA cases were classified into 119 cerebral infarction(75.8%), 11 cerebral hemorrhage(7.0%), 1 subarachnoid hemorrhage(0.6%) and 26 trasient ischemic attack. From the standards of symptom management, there were abnormality of a coated tongue(63.1%) in most cases, sleeping disorders(48.4%), excremental disorders(44.7%) and urinary disorders(36.9%) on admission. With regard to the rate of improvement in the standards of CVA management, excremental disorders improved 87.1% and emotional disorder 81.0%, swallowing disorder 78.7% and so on.

의사결정나무법을 이용한 설문지의 응답특성에 대한 임상적 검토

최재영,박성식,Choi, Jae-Young,Park, Seong-Sik 사상체질의학회 2003 사상체질의학회지 Vol.15 No.3

Objectives: This paper was for studying the constitutional differences between questionnaire and clinical diagnosis, and to be helpful to make a diagnosis Sasang constitution. Using the result of this study, it will be helpful to diagnose a Sasang constitution. Methods: There were 331 patients(135 men and 196 women) who answered questionnaire and were diagnosed by the Sasang constitution specialist at constitutional clinic of Dongguk Bundang Oriental Hospital. Using the response of questionnaire and several statistical techniques, we tried to find the characteristics of questionnaire response among each constitution and consistency between questionnaire and clinical diagnosis. Results: As a result of the analysis of the consistency between clinical diagnosis and questionnaire, the consistency was low degree(kappa value = 0.320) and Taeumin and Soeumin had more consistency than Soyangin.

복강경 부신절제술을 시행한 11예에 관한 임상적 고찰 ⁣고식적 수술법과의 비교⁣

최재영,고석환,이길연,이석환,이상목,박호철,홍성화,오수명,윤충,Jae Young Choi,Suck Hwan Koh,Kil Yeon Lee,Suk Hwan Lee,Sang Mok Lee,Ho Chul Park,Sung Wha Hong,Soo Myung Oh,and Choong Yoon 대한갑상선-내분비외과학회 2003 The Koreran journal of Endocrine Surgery Vol.3 No.2