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최원층(Won Choong Choi),박경미(Kyeong Mee Park) 대한내과학회 1995 대한내과학회지 Vol.48 No.3
N/A Objectives: Impairment of liver function was observed in many patients with different forms of obstructive jaundice. To clarify the mechanism of these impairment we examined liver histology of experimental rats with obstrctive jaundice induced by bile duct ligation at two time periods. Methods: The common bile duct of rats was ligated by laparotomy and control rats also underwent laparotomy, but the bile duct was not ligated. At two time periods after bile duct ligation (group A: 20days, group B: 25days) and at same period with group B in control rats, the livers were isolated and we did microscopic examination. Results: Bile ducts proliferation was observed from portal tracts to hepatic lobules in the biliary obstructed rats. In group B, hepatic lobules were destroyed by severe proliferation and fibrosis, and the boundary between hepatic lobules and portal tracts were indistinguishable. Conclusion: Impairment of liver function of the rats with obstrutive Jaundice may be due to loss of hepatocytes by bile duct proliferation and interstitial fibrosis.
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조원용,김민자,임기권,노정우,최원층,김형규 대한내과학회 1987 대한내과학회지 Vol.32 No.3
To see whether there is any clinical difference between urban residency and rural residency in KHF, and between oliguric type and non-oliguric type in urban residency KHF, we reviewed 123 KHF patients from Jan., 1981 to Dec., 1985 In urban residency, 28 patients lived in a city and have never been outside the city since last 2 months. In oliguric type of urban residency, 14 patients had lesser than 400 ml of urine in a day. We reviewed clinical findings, labratory findings, treatment and prognosis in cases of two types in urban residency KHF. The results were as follows; 1) The total number of urban residency was 28cases (22.8%) in 123cases of KHF. 2) In urban residency, male to female ratio was 4.6:1 and most common in 3rd decade. 3) The oliguric type in urban residency is 14cases (50%) 4) On clinical findings, there were fever, nausea and abdominal pain commonly, and which were milder in non-oliguric type. 5) There were facial flushing, CVA tenderness and petechia commonly, and which were milder in nonoliguric type, 6) On labratory findings most cases showed leukocytosis, proteinuria and hematuria, and renal function were more deteriorated in oliguric type. 7) The non-oliguric patients were cured by supportive care except one cases, oliguric patients needed dialysis treatment in half cases. 8) Except two cases (7.8%), which were discharged moribundly due to prolonged shock state in oliguric type, the prognosis were good in both types of urban residency KHF, relatively.
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