한국해양대학교 해양공학과 최원석 조교수

최원석 대한조선학회 2023 大韓造船學會誌 Vol.60 No.1

The significance of avian influenza virus mouse-adaptation and its application in characterizing the efficacy of new vaccines and therapeutic agents

최원석,Khristine Kaith S. Lloren,백윤희,송민석 대한백신학회 2017 Clinical and Experimental Vaccine Research Vol.6 No.2

Due to the increased frequency of interspecies transmission of avian influenza viruses, studies designed to identify the molecular determinants that could lead to an expansion of the host range have been increased. A variety of mouse-based mammalian-adaptation studies of avian influenza viruses have provided insight into the genetic alterations of various avian influenza subtypes that may contribute to the generation of a pandemic virus. To date, the studies have focused on avian influenza subtypes H5, H6, H7, H9, and H10 which have recently caused human infection. Although mice cannot fully reflect the course of human infection with avian influenza, these mouse studies can be a useful method for investigating potential mammalian adaptive markers against newly emerging avian influenza viruses. In addition, due to the lack of appropriate vaccines against the diverse emerging influenza viruses, the generation of mouse-adapted lethal variants could contribute to the development of effective vaccines or therapeutic agents. Within this review, we will summarize studies that have demonstrated adaptations of avian influenza viruses that result in an altered pathogenicity in mice which may suggest the potential application of mouse-lethal strains in the development of influenza vaccines and/or therapeutics in preclinical studies.

계절 인플루엔자의 항바이러스제 사용 지침

최원석,이재갑,이희영,백지현,김윤경,기세윤,정혜원,김영근,송준영,위성헌,이진수 대한감염학회 2012 Infection and Chemotherapy Vol.44 No.4

Influenza, a highly communicable disease, causes variable epidemics annually and imposes public health problems and socioeconomic burden. In addition to vaccine, antiviral medication has an important role in treatment and prevention of influenza virus infection. As influenza virus is undergoing change of antigenicity and antiviral susceptibility, proper use of antiviral medication is important. This guideline encompasses treatment and chemoprophylaxis with antiviral medications for seasonal influenza based on the current influenza situation in Korea. These recommendations were intended for physicians in all medical specialties who provide care for influenza patients.

Immunogenicity and Safety of a Live Attenuated Zoster Vaccine (ZOSTAVAXTM) in Korean Adults

최원석,최준용,최정현,엄중식,김상일,배현주,백경란,손장욱,정희진 대한의학회 2016 Journal of Korean medical science Vol.31 No.1

A live attenuated zoster vaccine (ZOSTAVAXTM, Merck & Co. , Inc.) was approved by the Korea Ministry of Food and Drug Safety in 2009. However, the immunogenicity and safety of the vaccine has not been assessed in Korean population. This is multi-center, open‑label, single‑arm study performed with 180 healthy Korean adults ≥ 50 yr of age. The geometric mean titer (GMT) and geometric mean fold rise (GMFR) of varicella zoster virus (VZV) antibodies were measured by glycoprotein enzyme-linked immunosorbent assay (gpELISA) at 4 weeks post-vaccination. Subjects were followed for exposure to varicella or herpes zoster (HZ), the development of any varicella/varicella‑like or HZ/HZ‑like rashes, and any other clinical adverse experiences (AEs) for 42 days post-vaccination. For the 166 subjects included in the per-protocol population, the GMT at Day 1 was 66.9. At 4 weeks postvaccination, the GMT for this population was 185.4, with a GMFR of 2.8 (95% CI, 2.5- 3.1). Of the 180 subjects vaccinated, 62.8% experienced ≥ 1 AE, with 53.3% of subjects reporting injection-site AEs. The most frequently reported injection-site AEs were erythema (45.0%) with the majority being mild in intensity. Overall, 44 (24.4%) subjects experienced ≥ 1 systemic AE, 10 (5.5%) subjects experienced a systemic vaccine-related AE, and 3 (1.7%) subjects experienced ≥ 1 serious AE not related to vaccine. No subjects reported a VZV-like rash. There was no subject of death and no subject discontinued due to an adverse event. A single dose of zoster vaccine induced VZV-specific gpELISA antibody response and was generally well-tolerated in healthy Korean adults ≥ 50 yr of age (registry at www. clinicaltrial.gov No. NCT01556451).

문화요소의 분포를 통해 본 문화지역의 특징 및 구분 : 영남지방 고을과 마을의 풍수비보 요소를 중심으로

崔元碩 역사문화학회 2009 역사문화학회 학술대회 발표자료집 Vol.2009 No.2월

Sensitiv Imago^TM 측정에 의한 야뇨증 환아의 검사 결과 보고

최원석,김덕곤,이진용,Choi, Won Seok,Kim, Deog Gon,Lee, Jin Yong 대한한방소아과학회 2014 대한한방소아과학회지 Vol.28 No.4

Objectives The purpose of this study is to report the nocturnal enuresis in children using Sensitiv $Imago^{TM}$. Methods Twenty nocturnal enuresis children were tested using Sensitiv $Imago^{TM}$. Results 10 cases showed the lowest score at filter $#5^*$ and 7 cases showed the lowest score at filter $6^*$ in {Express Monitoring} of {Review of System Disorders of Homeostasis}. Conclusions Further study with more samples is necessary to establish the accuracy of Sensitiv $Imago^{TM}$.

裨補의 槪念과 原理

최원석 고려대학교 민족문화연구원 2001 民族文化硏究 Vol.34 No.-

본 논고는 裨補의 개념과 원리를 고찰한 것으로서, 한국의 비보론은 크게 불교적 비보론과 풍수적 비보론으로 대별된다. 불교와 풍수의 비보적 논의는 각각 佛國土地理觀과 明堂吉地觀이라는 理想鄕 관념에 기초하고 있으며, 비보는 이를 이루기 위한 수단과 방법으로 강구된다. 불교적인 비보에는 寺·塔·佛像·幢竿 등이 활용되었고, 풍수적인 비보에는 造山·숲·못·象微物 등이 이용되었다. 풍수적 비보론은 기존 풍수론의 산, 수, 방위라는 3요소에 문화 요소를 더한 4자의 상호조합으로 구성된다. 이러한 비보 수단은 共時的으로 장소나 조성 주체에 따라 적절히 채택되나, 通時的으로는 신앙적 비보 형태(사탑, 상징물 등)에서 합리적 비보형태(숲 등)로 발전하는 문화적 進化 양상을 보인다. 특히 비보풍수론은 풍수와 비보가 결합된 역사적 형태이자 풍수론의 발전적 개념으로서, 기능상 龍脈裨補·藏風裨補, 得水裨補, 形局裨補, 凶相遮蔽, 火氣防禦 등으로 분류될 수 있다. 풍수적 비보론은 역사적으로 한국풍수의 구성체계에서 擇地論과 더불어 양대 축을 이룬다. 비보 경관의 패턴과 구조에는 철학적으로 자연과 사람의 相補的 구성원리가 내재하고 있다. 따라서 비보란 자연과 인간사이의 공간적 대립구조를 諧和시키고 상보관계로 구성하는 조정 원리이자 실천 방책이라 규정할 수 있다. Feng-shui, once a dominant geo-mentality in northeastern Asian societies, has a special meaning in the history of Korean geography. Although present-day discourse of geography has been dominated by the so-called scientific' Western geography, it is also an undeniable fact that the harmonious rapport between the mankind and the environment has endured the test of time and hostile logic of spatial analysis. Traces of the spirit of topophilia and fragments of attachment to the earth are still feasible in our mind-set. The discussion in my dissertation develops in the wide framework of a traditional korean geo-mentality, and it concerns mainly with the regional differentiation of the ways in which human agency transform their environs in order to come closer to the ideal model of a feng-shui physiognomy. The Korean-geomancy has functioned not only as an ideology of a cosmic order but also as a locational factor for the selection of burial sites and settlement. The feng-shui rationale decrees that the selection of proper sites secures the well-being of local communities in general and the fortune of certain families in particular. However, this somewhat deterministic tone is only part of the story. There is enough room left for the action of human agency. A more active interpretation of the ideology renders that the partial deficiency of physiognomy can be addressed by means of bibo, or a geomantic enhancement of the sacredness of auspicious sites by the construction of special landscape features. As a supernatural guardian of the sacred sites, bibo is best understood as a harmonizing principle of the cosmic order working between mankind and nature. In the age of modernization, the feng-shui and bibo landscapes have lost their original aura. They have suffered from the ruthless attacks of the Enlightenment logic of science. However, the elan vital of feng-shui and bibo are still visible and strongly felt in the countryside.

1987년 6월 항쟁의 보루, 부산

최원석 민주화운동기념사업회 2019 민주화운동기념사업회 학술토론회 자료집 Vol.2019 No.-

파워센서를 이용한 Multi-carrier signal 전력측정 기술 연구

최원석,임윤식,황현석 대한전기학회 2019 대한전기학회 학술대회 논문집 Vol.2019 No.11

Science Technology - 산소의 두 얼굴

최원석,Choe, Won-Seok 한국정보통신기술협회 2012 TTA저널 Vol.143 No.-

90년대 TV 화장품 광고 중 아직도 많은 사람의 기억에 남아 있는 것은 이영애의 '산소 같은 여자'일 것이다. 이 광고는 이영애의 활기차고 탄력 있는 피부를 산소와 연결 지어 큰 성공을 거두었다. 또한, 신선한 공기를 공급한다는 점이 산소가 풍부한 공기를 공급한다는 의미일 정도로 산소는 좋은 이미지를 갖고 있다. 하지만 최근에는 웰빙과 노화에 관한 관심이 증가하면서 활성산소는 인체에서 제거해야 할 대상 1호로 꼽히며, 항산화제나 항산화 식품에 대한 인기가 그 어느 때보다 높다. 그러나 산소와 활성산소에 대해 흔히 알려진 이러한 사실과 달리 그 속에는 또 다른 반전이 숨어 있다.