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- 저자 : 최원범 ( Won Bum Choi ) (검색결과 4 건)
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갑상선기능항진증의 간소엽중심부 간세포손상의 진단적 평가를 위한 isocitrate dehydrogenase 활성도 측정
최원범(Won Bum Choi),정영화(Young Hwa Chung),정성애(Sung Ae Jung),송병철(Byung Cheol Song),김정아(Jeong A Kim),김정원(Jung Weon Kim),송일한(Il Han Song),장우영(Woo Young Chang),송영기(Young Kee Shong),이영상(Yung Sang Lee),서동진(Don 대한내과학회 2000 대한내과학회지 Vol.58 No.2
N/A Background : The zonal differentiation of hepatic necrosis is important in the aspect of treatment, follow-up and prognosis of patients. The purpose of this study was evaluating the clinical usefulness of serum isocitrate dehydrogenase (ICDH) as a marker of centrilobular hepatic necrosis in patients with hyperthyroidism. Methods : We determined the serum ICDH and alanine aminotransferase (ALT) activities in 56 patients with hyperthyroidism, 16 patients with chronic viral hepatitis, and 17 normal controls. Results : The activities of serum ICDH were significantly higher in patients with hyperthyroidism than those of patients with chronic viral hepatitis or normal control (p<0.01), even though those of serum ALT were higher in patients with chronic viral hepatitis (p<0.01). The ratio of serum ICDH and ALT activities were markedly different between the patients with hyperthyroidism and chronic viral hepatitis (p<0.001). There was a significant correlation between the serum ICDH and ALT activities in patients with hyperthyroidism as well as in those with chronic viral hepatitis (p<0.05). In patients with hyperthyroidism, the serum ICDH levels were more significantly correlated with serum triiodothyronine (T3) than thyroxine (T4) levels. In a patients with hyperthyroidism and elevated ALT levels, the serum ICDH activity decreased progressively and was normalized ultimately, as serum ALT level and thyroid function were normalized with antithyroid medication. Conclusion : The serum ICDH or ratio of serum ICDH and ALT activities might be useful clinically in differentiating the centrilobular from periportal hepatic necrosis, and following up the degree of hepatic necrosis in patients with hyperthyroidism.(Korean J Med 58:189-196, 2000)
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윤형민(Hyoung-Min Yoon),유동호(Dong-Ho Yu),김영세(Young-Se Kim),최원범(Won-Beum Choi),안재신(Jae-Shin Ahn),정규범(Gyu-Bum Jung) 한국정보기술학회 2007 Proceedings of KIIT Conference Vol.2007 No.-
본 논문에서는 PEMFC 연료전지 스택과 푸시-풀 컨버터로 구성된 연료전지 시스템을 설계, 해석 및 제작하였다. PEMFC 연료전지 스택의 동작원리와 조건을 기술하였고, 작동 및 테스트 하였다. 48개의 셀을 갖는 2kW 스택에 대하여 출력전압의 변동 범위는 28VDC에서 40VDC이다. 푸시-풀 컨버터는 입력 전압이 변동하며, 매우 낮으므로 선택되었다. 출력 전압을 제어하기 위하여 25kHz의 스위칭 주파수와 40kHz의 샘플링 주파수를 갖는 푸-시풀 컨버터 DSP제어기가 설계되고 제작되었다. 출력전압은 내부 전류 제어루프를 갖도록 설계하였다. 실험결과 컨버터의 효율은 대략 90% 정도이다. In this paper, a fuel cell power system, which consists of PEMFC fuel cell stack and push-pull converter, is designed, analyzed and implemented. The operation principle and conditions of the PEMFC fuel cell stack are reviewed, and discussed. The fuel cell stack is operated, and tested, also. For 2 kW stack with 48 series fuel cells, the output voltage range is from 28 VDC to 40 VDC. The push-pull converter is selected because the input voltage is varied and very low. To control the output voltage, DSP controller of the push-pull converter is designed, and implemented by 25 kHz switching frequency and 40 kHz sampling frequency. The output voltage is controlled by feedback loop with inner current loop. The efficiency is about 90% for the designed push-pull converter.
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연구CAD 를 이용한 개방감 측면에서의 주거내부 환경개선에 관한 실험적 연구
최무혁,신재억,최원범 경북대학교 환경과학연구소 1993 環境科學硏究所論文集 Vol.7 No.1
This study simulated various situations in residential environments by using CAD. We measured responses of subjects for the images, made an statistical analysis for the responses, and madea conclusion on the elements effecting sense of openness. An experimental samples consist of 28 on color and 32 on form. On the simulation image, questionaire were posed to 13 graduate students and 35 senior who major in architecture, and 53 university students in other major. The results were analized by SPSS PC+ package. The findings are summarized as follows. 1. The effects of color on the sense of openness are varied with sex, major field of study, color, colormatching pattern. Grey color near white, PB and YR on the whole give much sense of openness, but difference with sex must be considered. In color-matching pattern, generally high-lightness and low-saturation color-matching patterns take affirmative effects. 2. In the efects on the sense of openness in form, firstly, less physical optic obstacles have more affirmative effects on the sense of openness. secondly, the horizontal factors have more affirmative effects on the sense of openness than the vertical factors. 3. In the responses of subject on the sence of openness, there are more difference with sex than with major field of study. Therefore, in the simulation which CAD~omputer Graphics can realize environments like real world, common people who are not professional architect can be subject of question.
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경간동맥화학색전술에 의한 초기 관해 후 간세포암의 재발 양상에 관한 분석
서동진,최원범,정영화,이영상,양수현,송병철,성규보,윤현기,이재균 대한소화기학회 2000 대한소화기학회지 Vol.35 No.2
Background/Aims: We aimed to evaluate the recurrence rate of hepatocellular carcinoma (HCC) with initial excellent response by transarterial chemoembolization (TACE), and to find a better surveillance method that can detect the recurrent HCC of the early stage and ultimately improve the therapeutic efficacy of TACE. Methods: Out of 230 consecutive HCC patients treated with TACE, 77 showing remission, were followed prospectively for more than 12 months. Remission was defined as the case of no additional lipiodol uptake and no additional tumor vessel. Serum alpha-fetoprotein (AFP) levels and computerized tomography (CT) scans were examined every 3 months to detect recurrent HCCs. Hepatic angiography was also performed at the same interval; if no recurrence, 6 months later; after then, every 12 months. Results: Recurrent HCCs were detected in 40 patients after median 27 months of follow-up period. The recurrence rate of single nodular HCCs was lower than multinodular type. Local recurrence of HCCs with homogeneous lipiodol uptake was less frequent than that of HCCs with heterogeneous uptake. The 37% of recurrences were adjacent to original tumors and the 55% of recurrences were separated from them. The other 8% of recurrences occurred at both places. Among 40 recurrent cases, we detected 18 cases by serum AFP and CT scan, 19 cases by angiography, only 3 cases by lipiodol CT scan. The survival rates of HCC patients showing initial remission by TACE at 1, 2, and 3 year were 99%, 86%, and 64%, respectively. Conclusions: Our data indicate that regular angiography in addition to serum AFP and CT scan may be valuable in detecting recurrent HCCs and eventually improving the therapeutic effects of TACE. It also suggests that local injection therapy may be required to reduce recurrence, especially in HCCs with heterogeneous lipiodol uptake.
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