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제조방법을 달리한 경옥고의 고콜레스테롤혈증 흰쥐에 미치는 효능 비교 연구
최웅식 ( Ungsik Choe ),구가람 ( Garam Ku ),이아름 ( Ahreum Lee ),권오준 ( Ojun Kwon ),서영배 ( Young-bae Seo ) 대한본초학회 2017 大韓本草學會誌 Vol.32 No.3
Objectives: Kyeongok-go has the effect of antioxidant, anti-cancer, improving fatigue, and hyperlipidemia, but it is not easy to use in clinical practice becausee of the complicated manufacturing process of heat control and moisture control. The aim of this study was to explore the lipid improvement effect of new manufacturing methods prodeced Kyeongok-go in hyperlipidemia rats. Methods : The SD rats were divided randomly into 8 groups of six animals each : Normal rats (Nor), hyperlipidemia rats (Con), hyperlipidemia rats treated with Spirulina 60 ㎎/㎏(SP60), hyperlipidemia rats treated with Commercial Kyeongok-go 1 g/㎏ (K0), hyperlipidemia rats treated with Kyeongok-go manufactured by heating mantle 1 g/㎏ (K1), hyperlipidemia rats treated with ginseng fermentation Kyeongok-go 1 g/㎏ (KF), hyperlipidemia rats treated with Kyeongok-go with black ginseng 1 g/㎏ (BK), hyperlipidemia rats treated with black ginseng fermentation Kyeongok-go 1 g/㎏ (BKF). The experimental group induced hyperlipidemia by eating high cholesterol diet for 8 weeks. Also, we compared Kyeongok-go manufacturing method using the new method compared with traditional method. Results : As a result, the improvement effect of hyperlipemia using the new method showed the similar or better improvement effect compared with the conventional method, and it is considered that the Kyeongok-go manufacturing method using the new method can be substituted for the traditional Kyeongok-go manufacturing method. Conclusion : In conclusion, these results suggest that new manufacturing methods prodeced Kyeongok-go has the potential as a anti-hyperlipidemia material which possess lipid improvement activities.
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