Anaphylaxis to Chlorpheniramine Maleate and Literature Review

최용원,정민재,김혜원,정보영,박천욱 대한피부과학회 2019 Annals of Dermatology Vol.31 No.4

Chlorpheniramine maleate is commonly used antihistamine. Since antihistamines are the main therapeutic agents for symptomatic treatment of urticaria, anaphylaxis to antihistamines may lead to errors in diagnosis and treatment. We report a case of anaphylaxis induced by chlorpheniramine maleate confirmed by intradermal test. A 35-year-old female experienced history of anaphylaxis after intramuscular injection of chlorpheniramine maleate. Skin prick test was negative, but intradermal test was positive. Patient also experienced mild dizziness after intradermal test and refused to perform any further evaluation such as oral challenge test. Anaphylaxis for chlorpheniramine maleate is very rare but should be considered.

증상의 발현부터 치료의 시작까지 : 한국인의 공황장애 인식도 변화가 치료적 접근에 미친 영향

최용원,서호준,한상우,홍진표,이경욱,김세주,임세원,이상혁,양종철,이승재,박선철,김민숙,채정호 대한불안의학회 2019 대한불안의학회지 Vol.15 No.2

Objective : This study aimed to investigate the general process from the symptom onset to the psychiatric treatment in Korean panic patients and the effect of improved public awareness on it. Methods : This study has a retrospective design. The subjects were the new patients with panic disorder who visited the psychiatric outpatient clinic in twelve university-affiliated hospitals all across Korea. The medical chart was reviewed retrospectively and the data were collected including chief complaints of symptoms, recent stressors, the time to visit the psychiatric outpatient clinic, and visit of other departments and diagnostic approaches for their symptoms. Results : A total of 814 participants were included in the study. The most common department other than psychiatry the panic patients visited were cardiology (28.3%), general internal medicine (16.0%) and neurology (11.4%). The most frequently used diagnostic tests were a echocardiography (17.9%), 24-hour Holter mon-itoring (11.2%), and brain MRI (8.2%). Only 37.3% of participants visited psychiatric clinic directly. About 80% of participants visited psychiatric department within 1 year after their first panic symptoms and it took 13.8±13.7 weeks on average. Comparing before and after 2012, the number of participants increased who visit directly the psychiatric clinic without visiting other departments (p=0.002) and without visiting emergency room (p<0.001). Conclusions : Our results suggest that a substantial number of patients visit departments other than psychiatry when they experience first panic symptoms. However, most patients begin psychiatric treatment within 1 year after their first symptoms and the number of patient are increasing who visit psychiatric department directly without visiting other departments. (Anxiety and Mood 2019;15(2):61-67)

신뢰성 부품의 열화 감지 시스템 개발

최용원,박재웅 한국신뢰성학회 2023 한국신뢰성학회 학술대회논문집 Vol.2023 No.6

직무발명과 대학발명의 관계

최용원 한국전기전자재료학회 2000 전기전자재료 Vol.13 No.6

취득세 과세체계의 문제점 및 개선방안에 관한 연구

최용원,박성욱,김용기 한국세무학회 2019 세무학 연구 Vol.36 No.4

After the amendment of the local tax system in 2011, the taxation structure became more complicated and the problems still exist. The purpose of this study is to examine the problems in the reorganization process in 2010 and to find reasonable ways to improve them. To do this, the taxation structure was compared before and after the reorganization in 2010, and the results of this study are the followings. First, the registration tax (pre-consolidation) has a variety of taxation structure by reason of acquisition, property subject to taxation, and taxpayers, and there is no taxation logic. Secondly, the unreasonably heavy tax system and the structure of taxation became more complicated. As a way to improve these problems, the type of property subject to acquisition tax should be simplified to eliminate tax differentiation by type of acquisition. The same tax rates should be applied for the acquisition, inheritance, and free acquisition (excluding inheritance). The single tax rate is more reasonable compared to the rate of progressive taxation by the taxable section of a house. Finally, for the luxury property, the heavy tax system should improve correspondingly to the changes of time. 2011년 지방세목의 개정작업 이후 취득세 과세체계는 더욱 복잡해졌으며, 과세체계상 문제점이 그대로 존재하고 있는 것이 현실이다. 이에 본 연구는 2010년 개편과정에서의 문제점을 살펴보고, 개선방안을 제시하고자 한다. 이를 위해 과세체계를 2010년을 기준으로 개선 전과 후를 비교하였으며, 과세체계의 문제점은 다음과 같다. 첫째, 통합 전 등록세는 취득원인별, 과세대상 재산별, 납세의무자별로 다양한 세율체계를 지니고 있었으나, 과세논리가 결여되어 있었다. 두 세목을 통합하였을 때 세율은 과거 세율을 단순히 합산하였기 때문에 더욱 복잡해 졌다. 둘째, 합리적이지 못한 중과세 과세체계와 구조는 더욱 복잡해졌다. 이에 대한 개선방안으로는 첫째, 취득세 과세대상 재산의 종류를 단순화시키고, 취득유형별 세율차별화를 없애는 방향으로 간소화되어야 한다. 둘째, 유상취득, 상속, 상속이외의 무상취득에 대하여 동일한 세율을 적용하여야 하고, 주택에 대한 과세구간별 누진세율도 단일세율로 전환하는 것이 타당하다고 판단된다. 마지막으로 사치성재산 중과세제도도 시대변화에 상응하게 개편되어야한다.

높은 특이도와 민감도를 갖는 분자분광분석용 플라즈모닉 3차원 나노구조체 SERS 기판

최용원,오다원,강성우 한국표면공학회 2022 한국표면공학회 학술발표회 초록집 Vol.2022 No.6

Oral Maintenance Chemotherapy with 6-Mercaptopurine and Methotrexate in Patients with Acute Myeloid Leukemia Ineligible for Transplantation

최용원,정성현,안미선,이현우,강석윤,최진혁,박준성 대한의학회 2015 Journal of Korean medical science Vol.30 No.10

For decades, maintenance chemotherapy has failed to improve the cure rate or prolong the survival of patients with acute myeloid leukemia (AML), other than those with acute promyelocytic leukemia. Immediately after the first complete remission following consolidation therapy was obtained, oral maintenance chemotherapy (daily 6-mercaptopurine and weekly methotrexate) was given and continued for two years in transplant-ineligible AML patients. Leukemia-free survival (LFS) and overall survival (OS) were studied and compared between these patients and the historical control group who did not receive maintenance therapy. Consecutive 52 transplant-ineligible AML patients were analyzed. Among these patients, 27 received oral maintenance chemotherapy. No significant difference was found in the patients’ characteristics between the maintenance and the control groups. The median OS was 43 (95% CI, 19-67) and 19 (95% CI, 8-30) months in the maintenance and the control groups, respectively (P = 0.202). In the multivariate analysis, the presence of maintenance therapy was an independent prognostic factor for better OS (P = 0.021) and LFS (P = 0.024). Clinical benefit from maintenance chemotherapy was remarkable in older patients (≥ 60 yr) (P = 0.035), those with intermediate or unfavorable cytogenetics (P = 0.006), those with initial low blast count in peripheral blood (P = 0.044), and those receiving less than two cycles of consolidation therapy (P = 0.017). Maintenance oral chemotherapy as a post-remission therapy can prolong the survival of patients with AML who are not eligible for transplantation, particularly older patients, those with intermediate or unfavorable cytogenetics, those with initial low blast count, and those receiving less than two cycles of consolidation therapy.

해양환경하에서 19Cr-9Ni 스테인리스강의 캐비테이션 및 전기화학적 특성

최용원,이정형,김성종 해양환경안전학회 2013 해양환경안전학회 학술발표대회 논문집 Vol.2013 No.11

양측성 관상동정맥루 1예

최용원,오석규,이재훈,이상재,권경희,최은경,김남호,정진원 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.1

저자들은 호흡곤란, 흉부불쾌감, 심계항진 등을 주소로 내원한 환자에서 경흉부 및 경식도 심초음파 검사상 주폐동맥에서 이완기에 전행하는 지속적인 혈류의 흐름을 관찰하고, 관상동맥 조영술을 통해 좌전하행지 중간부위와 우관상동맥 근위부에서 각각 기시하여 공통경로를 이루면서 주폐동맥으로 유입되는 양측성 관상동정맥루를 보이는 드문 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. A coronary arteriovenous fistula is infrequently encountered vascular communication between a coronary artery and a cardiac chamber, a great artery or the vena cava. It is the most common congenital anomaly that can affect coronary perfusion. Bilateral involvement of coronary fistula constitutes an uncommon subgroup of coronary arteriovenous fistulas. A 69 year-old female patient presented with chest discomfort, palpitation, and dyspnea. In the echocardiography, doppler color flow imaging visualized abnormal flow signals with mosaic appearance in the main pulmonary artery during diastolic phase. Coronary angiography revealed arteriovenous fistula arising from the left anterior descending artery and the right coronary artery. Both coronary arteriovenous fistulas drained into the main pulmonary artery. We report a case of bilateral coronary arteriovenous fistula that was confirmed by echocariography and coronary angiography.

주택 취득세의 차등세율구조가 주택거래에 미치는 영향에 관한 연구

최용원,박성욱,김서현 한국세무학회 2022 세무와 회계저널 Vol.23 No.6

This study examines the problems of the current system, focusing on the tax rate structure of the acquisition tax, and suggests a rational improvement plan. In particular, we examine whether the discontinuity of tax rates following the diagonal progressive tax rate structure, which sequentially increases the acquisition tax rate in the acquisition price range between 600 million won and 900 million won, as well as the simple progressive tax rate structure, causes market distortion. To this end, it is verified whether the actual transaction distortion has been alleviated as the government's legislative purpose by analyzing the acquisition tax rate from the time when the acquisition tax rate was settled as a simple progressive tax rate to the year after it was implemented after being changed to a diagonal progressive tax rate structure. Specifically, since the largest amount of housing transactions in Seoul corresponds to apartments, it analyzes the amount of apartment transactions in Seoul from 2014 to 2021 to determine whether there is a threshold effect in the differential tax rate section of 600 million won and 900 million won. As a result of the empirical analysis of this study, as the differential tax rates are applied at 600 million won and 900 million won, the proportion of transactions in the area where the high tax rate is applied in the marginal area of the differential tax rate is significantly reduced. This means that market distortion occurs due to the discontinuity of the tax rate. In addition, even after January 1, 2020, after the change to the diagonal progressive tax rate structure, this market distortion phenomenon is alleviated, but it still exists. As a result, market distortion occurs under a simple progressive tax rate structure or a diagonal progressive tax rate structure, so it is proposed to convert the acquisition tax rate into a single proportional tax rate when acquiring proposed to convert the acquisition tax rate into a single proportional tax rate when acquiring housing for a fee to enhance the efficiency of transactions. In this case, the single proportional tax rate needs to be determined in consideration of the single proportional tax rate and equity of general real estate. Since demand for housing coexists with residential and speculative purposes, the paid acquisition tax rate of housing is unified to 4% which is the standard tax rate of general real estate, and housing acquisition for actual residential purposes is partially exempted using the Local Tax Restriction Act. This study makes a contribution through empirically analyzing the policy effect of tax rate system reform through market distortion, and presents a plan to improve the current housing acquisition tax rate system based on this.