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비후성 반흔 각질세포와 정상 각질세포의 유전자 비교분석
최성원,정호윤,임영국,김훈남,오지원,김문규,전세화,홍용택,Choi, Sung-Won,Chung, Ho-Yun,Lim, Young-Kook,Kim, Hoon-Nam,Oh, Ji-Won,Kim, Moon-Kyu,Jeon, Sae-Hwa,Hong, Yong-Taek 대한성형외과학회 2010 Archives of Plastic Surgery Vol.37 No.4
Purpose: There is no clear evidence of the original cause of hypertrophic scar, and the effective method of treatment is not yet established. Recently the steps of searching in gene and molecular level are proceeding. we are trying to recognize the difference between keratinocytes of hypertrophic scar and normal skin. Then we do support the comprehension of the scar formation mechanism and scar management. Methods: Total RNAs were extracted from cultured keratinocytes from 4 hypertrophic scars and normal skins. The cDNA chips were prepared. A total of 3063 cDNAs from human cDNA library were arrayed. And the scanning data were analyzed. Results: On microarray, heat shock protein, pyruvate kinase, tumor rejection antigen were more than 2 fold intensity genes. Among them, heat shock 70 kd protein showed the strongest intensity difference. Conclusion: In this study, it can be concluded that heat shock proteins play an important role in the process of wound healing and scar formation. This study provides basic biologic information for scar research. The new way of the prevention and treatment of scar formation would be introduced with further investigations.
최성원,김광수,김유철,Sung Won Choi,MD,Kwang Soo Kim,MD,Yu Cheol Kim,MD 대한안과학회 2014 대한안과학회지 Vol.55 No.12
Purpose: To investigate the risk factors and the factors affecting surgical and visual outcomes of rhegmatogenous retinal detachment in patients under 40 years of age. Methods: This retrospective study included 88 patients (96 eyes) diagnosed with rhegmatogenous retinal detachment that were followed up for more than 3 months postoperatively. Patients were categorized into 3 groups according to age. The etiologic risk factors and the primary anatomical and functional success rates were analyzed. Preoperative factors that could affect postoperative visual acuity and primary anatomical outcome, such as subretinal strands and proliferative vitreoretinopathy (grade C or worse), were analyzed. Results: Myopia more severe than -4.0 diopters was the most common predisposing factor in all 3 groups. Anatomical success rates and functional success rates were not significantly different among the groups. Prevalence of macular detachment and proliferative vitreoretinopathy were highest in group 1. The presence of subretinal strands was highest in group 2 and proliferative vitreoretinopathy was highest in group 1. Patients with preoperative subretinal strands showed a lower primary anatomical success rate in group 1 and poor postoperative visual acuity in groups 1 and 2. Patients with proliferative vitreoretinopathy had poor postoperative visual acuity however there was no significant difference in primary anatomical success rate among the groups.Conclusions: Proliferative vitreoretinopathy did not affect the anatomical success rate but did affect visual outcome in rhegmatogenous retinal detachment in patients under age 40. Subretinal strands contributed to a lower anatomical success rate and poorer visual outcome in such patients that were under age 18. J Korean Ophthalmol Soc 2014;55(12):1808-1813
예측알고리즘 적용을 위한 데이터세트 구성이 근적외선 분광광도계를 이용한 옥수수 품질평가에 미치는 영향
최성원,이창석,박창희,김동희,박성권,김법균,문상호,Choi, Sung-Won,Lee, Chang-Sug,Park, Chang-Hee,Kim, Dong-Hee,Park, Sung-Kwon,Kim, Beob-Gyun,Moon, Sang-Ho 한국축산환경학회 2014 한국축산시설환경학회지 Vol.20 No.3
The objectives were to assess the use of near-infrared reflectance spectroscopy (NIRS) as a tool for estimating nutrient compositions of corn kernel, and to apply an NIRS-based indium gallium arsenide array detector to the system for collecting spectra and analyzing calibration equations using equipments designed for field application. Partial Least Squares Regression (PLSR) was employed to develop calibration equations based on representative data sets. The kennard-stone algorithm was applied to induce a calibration set and a validation set. As a result, the method for structuring a calibration set significantly affected prediction accuracy. The prediction of chemical composition of corn kernel resulted in the following (kennard-stone algorithm: relative) moisture ($R^2=0.82$, RMSEP=0.183), crude protein ($R^2=0.80$, RMSEP=0.142), crude fat ($R^2=0.84$, RMSEP=0.098), crude fiber ($R^2=0.74$, RMSEP=0.098), and crude ash ($R^2=0.81$, RMSEP=0.048). Result of this experiment showed the potential of NIRS to predict the chemical composition of corn kernel.
최성원,김유철.Sung Won Choi. MD. Yu Cheol Kim. MD 대한안과학회 2014 대한안과학회지 Vol.55 No.4
Purpose: To report a case of lipemia retinalis in a patient with diabetes. Case summary: A 27-year-old female with type 2 diabetes visited our clinic with visual disturbance in her left eye while being followed up from a pars plana vitrectomy in her right eye for proliferative diabetic retinopathy. On fundus examination of both eyes, the retinal vessels were creamy white and the retinal veins were undistinguishable from the retinal arteries. The serum triglyceride level was 2,676 mg/dL. The patient was asymptomatic except for visual impairment due to vitreous hemorrhage in her left eye. The patient was diagnosed with lipemia retinalis and chylomicronemia syndrome. After controlling the triglyceride level, funduscopic findings in the both eyes were improved. However, the visual acuity in her right eye remained unchanged. Conclusions: Lipemia retinalis can be a sign of a systemic condition although it may not affect visual acuity. Fundus examination may be a useful tool in the early diagnosis of hyperlipidemia. J Korean Ophthalmol Soc 2014;55(4):623-627
단안 상사근 마비와 동반된 수평 사시의 특징 및 치료 예후
최성원,정세환,라상훈,Sung Won Choi,Se Hwan Jung,Sang Hoon Rah 대한안과학회 2007 대한안과학회지 Vol.48 No.3
Purpose: To review the clinical characteristics and treatment outcomes in horizontal strabismus combined with unilateral superior oblique palsy (SOP). Methods: A retrospective review of medical records was conducted in 21 patients with unilateral SOP treated between January 2001 and December 2005. Patients had more than 6 months of follow-up at the Department of Ophthalmology, Wonju College of Medicine. Results: Among 21 patients (11 male, 10 female) with unilateral SOP, 57.1% of patients had horizontal strabismus. The mean vertical deviation was 12.56±3.81 (8~24) PD. All patients with horizontal strabismus had exotropia and the mean deviation was 10.57±4.58 (6~20) PD. A standard 10mm inferior oblique (IO) recession was performed uniformly at the paretic eye in all patients. In 7 of the patients (58.3%, exotropia greater than or equal to 10PD), horizontal rectus muscle recession was performed simultaneously. In these 7 cases, vertical and horizontal deviation less than or equal to 4PD was achieved (one patient with 10PD remaining hypertropia excluded). In 5 cases with exodeviation less than 10PD, isolated IO recession without horizontal rectus recession on the ipsilateral side achieved orthophoria in the primary position. In 9 cases of isolated SOP, all patients showed orthophoria in the primary position. Conclusions: This study demonstrates horizontal strabismus is combined with unilateral SOP in a high percentage of patients. Additionally, in all cases, all the incidents of horizontal deviation was involved exotropia. A standard 10 mm recession of the IO in combination with horizontal rectus recession is an effective surgical technique. It has an especially high success rate in patients with unilateral SOP (≤14PD vertical deviation) with exodeviation greater than 10PD. In patients with exodeviation less than 10PD, an isolated IO recession is sufficiently effective.
김경연 ( Kyung Yeon Kim ),백무열 ( Moo Yeol Baik ),박천석 ( Cheon Seok Park ),최성원 ( Sung Won Choi ),김창남 ( Chang Nam Kim ),김병용 ( Byung Yong Kim ) 한국식품영양학회 2013 韓國食品營養學會誌 Vol.26 No.1
죽의 기능성 향상을 위하여 2:1:1:1의 배합으로 혼합한 한약재료(가시오가피, 숙지황, 산약, 백복령)와 닭가슴살 등의 재료를 사용해 한방 영양죽을 제조하였다. 한방 닭죽의 DPPH radical 소거능, SOD 유사활성, 맛의 선호도, cost는 수학적인 canonical model과 trace plot을 이용하여 분석한 결과, SOD 유사활성 이외에는 각 성분들이 독립적으로 작용하여 상호작용이 없는 선형 모델을 보여주었다. DPPH radical 소거능, SOD 유사활성, 맛의 선호도를 최대로, cost를 최소로 목적 범위를 설정하고, 각각의 canonical 계수를 이용하여 수적 최적화를 통하여 최적 배합비를 구한 결과, 한약 혼합물 101g, 닭가슴살 38.66g, 찹쌀 비율 41.34g의 최적 배합비를 구하였으며, 이 배합비에 따른 맛의 선호도는 6.39, DPPH radical 소거능은 17.25㎎VCE/ℓ, SOD 유사활성은 2.25%, cost는 1,382.39 won으로 나타났으며, 여러 결과들 사이에 최적화된 한 값에 수렴하는 desirability는 0.714로 나타났다. 이는 한약혼합물이 많을수록 기능성 면에서는 높게 나타나지만 맛의 선호도면에서는 낮게 나타냈고, 닭가슴살의 경우에도 그 함량이 많을수록 맛의 선호도는 올라갔지만 그에 반해 cost가 높게 올라간 것을 반영한 결과로 사료된다. The objectives of this study were to develop porridge with medicinal herbs and chicken breast meat and to find out the optimum mixing ratio. Several herb extracts such as Acanthopanacis senticosus, Rehmannia glutinosa, Disocorea japonica, and Poria cocos Wolf were used in the ratio of 2, 1, 1, and 1, respectively. The optimum processing condition for herbal chicken porridge was determined by a design expert program. Seventeen experimental points were selected, and herb extracts (82∼101g), chicken breast meat (30∼50g), and glutinous rice (40∼60g) were chosen as the independent variables. The measured responses were preference of taste, DPPH radical scavenging, SOD-like activity, and cost. The optimum formulation of herbal chicken porridge using the numerical analysis was set at herbal extracts (101g), chicken breast meat (38.66g), and glutinous rice (41.34g) with a 0.714 desirability value. DPPH radical scavenging effect, preference of taste and the cost showed a linear model, whereas SOD-like activity showed a quadratic model indicating a higher interaction among the mixture. As a result of proximate composition of optimized herbal chicken porridge, the contents of moisture, carbohydrate, crude protein, crude lipid, and ash contents were 76.4, 9.0, 1.4, 0.5, and 1.6%, the calories of the porridge was 46.1kcal/100g.
〈코코〉를 통해 본 3D 디지털 애니메이션의 미학적 고찰
최성원(Choi, Sung-Won) 한국만화애니메이션학회 2018 만화애니메이션연구 Vol.- No.52
3D 디지털 애니메이션 "코코(Coco)"는 멕시코 공휴일인 망자의 날을 기반으로 ‘애드리안 몰리나가’가 각본을 ‘리 언크리치’가 집필·감독한 장편 3D 애니메이션으로 픽사(Pixar) 애니메이션 스튜디오가 제작하고 ‘월트 디즈니 픽쳐스’가 배급한 뮤지컬 영화이다. 이 장편 3D 애니메이션은 제90회 아카데미 장편 애니메이션 부문에서 작품 및 주제가상을 수상 하였다 3D 디지털 애니메이션 `코코(Coco)`가 가상현실 속에서 일어난 영화이고, 전통적 예술 형식과는 달리 시 · 공간의 범주를 동시에 포함하고 있지만 ‘코코’는 관객을 가상의 세계로 몰입시키고 감동 주었다. 그 이유는 작가와 감독이 현실의 ‘총체성’을 인식하고 이를 담고자 하는 확고하고도 생기 넘치는 세계관 때문이다. `코코(Coco)`가 관객에게 충족감을 준 이유는 영화 자체의 총체성을 기준으로 대상의 묘사와 스토리텔링의 서사 형식이 적용되어 있고 이 모든 과정 하나하나가 관찰자의 심리를 기준으로 전체적인 스토리의 서사와 묘사가 이루어졌으며, ‘코코’는 작품 그 자체로 충족한 자율성을 지니고 있음을 의미하디. 즉 작품을 보는 수용자는 자신의 지각행위 가운데 ‘코코’의 잠재적인 의미를 이해하게 되고 그 결과 관객은 ‘코코’를 가상의 캐릭터가 아닌 내 앞에 존재하는 캐릭터 즉 현실적인 의미 존재로 완성 시켰음을 증명하고 있다. 따라서 ‘코코’와 같은 3D 디지털 애니메이션은 형식적 특성에만 얽매이지 말고, 대상의 묘사와 대상들과의 관계라는 측면에서의 ‘서사’라는 상호 연계성 속에서 그리고 총체적 의미 내에서 이러한 단위들이 설명되어야 할 것이다. 즉 3D 애니메이션은 아직도 그 매체의 특성 때문에 예술로서 많은 논란이 있지만 3D 디지털 애니메이션의 형식적 특성과 더불어 예술의 근본적 문제인 상상력을 통해 질료적 형태로 어떻게 재현되는지를 밝힌다면 독자적인 예술의 한 장르로서 정립될 수 있다. 따라서 본 논문은 예술의 한 장르로서 승화시키기 위해 타자의 예술 양식이 되어버린 3D 디지털 애니메이션을 어떠한 방식으로 정의해야 하는지에 대해서 논해 보고자 한다. Coco is a 2017 American 3D computer-animated fantasy film produced by Pixar Animation Studios and released by Walt Disney Pictures. Based on an original idea by Lee Unkrich, it is directed by him and co-directed by Adrian Molina. The film`s voice cast stars Anthony Gonzalez, Gael García Bernal, Benjamin Bratt, Alanna Ubach, Renée Victor, Ana Ofelia Murguía, and Edward James Olmos. The story follows a 12-year-old boy named Miguel who is accidentally transported to the Land of the Dead, where he seeks the help of his deceased musician great-great-grandfather to return him to his family among the living. Coco, 3D animation, was said to be movie in virtual reality, and differed from traditional art to include time and space and to let spectator devote to virtual world. This was because `Coco` had autonomy of the work. The one who watched work could understand potential value of digital animation and to complete realistic existence. Therefore, digital animation like Coco should not be adhered to formal characteristics and should be described from point of view of mutual relation between description and object. After aesthetic reflection, 3D animation could be defined to be a genre of independent art. This study investigated definition of 3D animation being third party"s art form in order to make a genre of the art.
해체,제거 작업 시 석면함유 건축자재에서 발생되는 섬유 및 입자상 물질의 특성
최성원 ( Sung Won Choi ),장광명 ( Kwang Myoung Jang ),박경훈 ( Kyung Hoon Park ),김대종 ( Dae Jong Kim ),김현욱 ( Hyun Wook Kim ) 한국산업보건학회 2015 한국산업보건학회지 Vol.25 No.2
Objectives: This study focused on three aspects: characterizing concentrations of airborne particles by size distributions and asbestos fibers generated by various building materials; analyzing the characteristics of fibers produced by each simulation and asbestos fibers released from ACBMs; and investigating correlations of airborne asbestos fibers and particles generated and association of particle and asbestos concentrations. Methods: We selected three ACBMs including an insulation board, cement asbestos slate and wallboard. We constructed 4 scenarios; a) crushing with a hammer; b) cutting with a industrial knife; c) brushing with a metal brush; and d) tightening & loosening with a hand drill. We implemented one simulation for 30 seconds followed by 30 seconds resting period. We repeated a total of 5 cycles for 5 minutes. Results: The highest concentration of particulate & fibrous matters was from crushing with a hammer in each scenario followed by brushing with a metal brush, cutting with a industrial knife, and tightening & loosening with a hand drill. For ACBMs studied, asbestos concentrations were highest from an insulation board followed by cement asbestos slate, and wallboard. No difference in terms of concentration was found between an insulation board and asbestos slate. Fibers with 5~20 μm in length were included in 76~90% of total fibrous matters. The distribution of the straight form fibers was greater than that of the curl form. About 90% of PMTotal released from ACBMs was consisted of PM10 while only 10% of PMTotal was PM2.5. Particulate matters like PM2.5 was significantly correlated with fibrous matters(R2=0.81). Conclusions: We found ACBMs can significantly release asbestos fibers as well as PM2.5. Concentrations of asbestos generated by ACBMs were well correlated with PM2.5.