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PET- CT in Localized Oropharyngeal Amyloidosis : A Case Report and Literature Review
이상하,박정제,권오진,최봉회 대한이비인후과학회 부산,울산,경남 지부회 2014 임상이비인후과 Vol.25 No.2
Amyloidosis is typically a systemic depositional disease, diagnosed from clinical symptoms and signs in conjunction with histopathology. When occurring in the head and neck, lesions most often involve the larynx, nasopharynx, tongue, palate, and trachea. Primary localized oropharyngeal amyloidosis is, however, an uncommon finding. We present a case of 76-year-old man with primary localized oropharyngeal amyloidosis diagnosed by biopsy and generalized laboratory tests. We compared the pattern of 18F-FDG uptake in our case with others reported in the literature as a way to differentiate systemic and localized types of amyloidosis. In this case, no definitive 18F-FDG uptake by amyloid tissue was seen on PET-CT. The results of this case study add to the evidence that 18F-FDG PET-CT seems not to be a critical tool for the differentiation of localized from systemic amyloidosis.
Usefulness of 18F-fluoride PET/CT in Breast Cancer Patients with Osteosclerotic Bone Metastases
윤석호,김구상,강석윤,송희성,조경숙,최봉회,이수진,윤준기,안영실 대한핵의학회 2013 핵의학 분자영상 Vol.47 No.1
Purpose Bone metastasis is an important factor for the treatment and prognosis of breast cancer patients. Whole-body bone scintigraphy (WBBS) can evaluate skeletal metastases,and 18F-FDG PET/CT seems to exhibit high specificity and accuracy in detecting bone metastases. However, there is a limitation of 18F-FDG PET in assessing sclerotic bone metastases because some lesions may be undetectable. Recent studies showed that 18F-fluoride PET/CT is more sensitive than WBBS in detecting bone metastases. This study aims to evaluate the usefulness of 18F-fluoride PET/CT by comparing it with WBBS and 18F-FDG PET/CT in breast cancer patients with osteosclerotic skeletal metastases. Materials and Methods Nine breast cancer patients with suspected bone metastases (9 females; mean age ± SD, 55.6 ±10.0 years) underwent 99mTc-MDP WBBS, 18F-FDG PET/CT and 18F-fluoride PET/CT. Lesion-based analysis of five regions of the skeletons (skull, vertebral column, thoracic cage,pelvic bones and long bones of extremities) and patient-based analysis were performed. Results 18F-fluoride PET/CT, 18F-FDG PET/CT and WBBS detected 49, 20 and 25 true metastases, respectively. Sensitivity,specificity, positive predictive value and negative predictive value of 18F-fluoride PET/CT were 94.2 %, 46.3 %,57.7 % and 91.2 %, respectively. Most true metastatic lesions on 18F-fluoride PET/CT had osteosclerotic change (45/49,91.8 %), and only four lesions showed osteolytic change. Most lesions on 18F-FDG PET/CT also demonstrated osteosclerotic change (17/20, 85.0 %) with three osteolytic lesions. All true metastatic lesions detected on WBBS and 18F-FDG PET/CT were identified on 18F-fluoride PET/CT. Conclusion 18F-fluoride PET/CT is superior to WBBS or 18F-FDG PET/CT in detecting osteosclerotic metastatic lesions. 18F-fluoride PET/CT might be useful in evaluating osteosclerotic metastases in breast cancer patients.