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특집: 주요 알레르기질환의 진단과 치료 : 호산구성 폐렴의 진단과 치료
최동철 ( Dong Chull Choi ) 대한내과학회 2009 대한내과학회지 Vol.76 No.3
The eosinophilic lung diseases include various pulmonary disorders linked by common finding of an increased peripheral or tissue eosinophils. During the past decades, there has been a rapid increase in the understanding of eosinophil biology. However, there is no consensus about the classification and optimal treatment for eosinophilic lung diseases. Better understanding of the factors that regulate eosinophil traffic in the lung will leads us to better understanding of eosinophilic lung diseases. (Korean J Med 76:268-273, 2009)
최동철 ( Dong Chull Choi ) 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.4
Blood eosinophilia can be induced by either the cytokine- mediated reactive phenomenon (secondary) or the integral phenotype of an underlying hematological neoplasm (primary). Secondary eosinophilia is usually associated with parasitosis in underdeveloped countries or allergic diseases in developed countries. Initial approaches should focus on excluding possible causes of secondary eosinophilia, including helminthic parasite infections, undiagnosed allergic diseases, varied types of adverse drug reactions, and other eosinophil- associated syndromes, such as eosinophilic gastroenteritis and eosinophilic lung diseases. If secondary eosinophilia is excluded, attention must be directed to considerations of varied other forms of primary eosinophilia. Primary eosinophilia can be classified as clonal or idiopathic depending on the presence or absence of molecular, cytogenetic or histological evidence for myeloid malignancy. This article presents a comprehensive review of both secondary and primary eosinophilic disorders with some author`s clinical experience with hypereosinophilia. (Korean J Asthma Allergy Clin Immunol 2011;31:237-245)
폐 및 폐외결핵환자에서의 T 림프구 매개성 면역기능의 변화에 관한 연구
최동철 ( Dong Chull Choi ),심태선 ( Tae Sun Shim ),조상헌 ( Sang Heon Cho ),정기호 ( Ki Ho Jung ),현인규 ( In Gyu Hyun ),유철규 ( Chul Gyu Yoo ),김영환 ( Young Whan Kim ),심영수 ( Young Soo Shim ),김건열 ( Keun Youl Kim ),한용철 ( 대한결핵 및 호흡기학회 1992 Tuberculosis and Respiratory Diseases Vol.39 No.1
정량분무식 에어러졸 사용시 propellant에 의한 기도수축반응
반준우,윤호주,손지웅,조상헌,최동철,민경업,김유영 (Jun Woo Bahn,Ho Joo Yoon,Jee Woong Son,Sang Heon Cho,Dong Chull Choi,Kyung Up Min,Yon Young Kim) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.1
Background: Bronchoconstriction associated with aerosolized agents delivered by a metered dose inhaler (MDI) is relatively uncommon, but has been of particular interest. Material and Method: In this study, we investigated to what extent the inert ingredients and propellants (freons) influence pulmonary function in 25 asthmatic patients. Forced expiratory volume in one second(FEV,) was measured by spirometry, Autospira HI 498(Chest, Japan) before and 1, 3, 5 and 10 minutes after the inhalation of saline control and MDI-placebo containing freons and inert ingredients. Res ult: Twenty four % (6/25) of asthmatics experienced a decrease in FEV20 by 10% or greater when compared to saline control. Number of positive cases in steroid dependent asthmatics is significantly higher compared to non-steroid dependent asthmatics. (p <0.05) Bronchoconstriction associated with the use of MDI-placebo appeared within 3 to 5 minutes and resolved spontaneouly at 10 minutes after the inhalation. Conclusion: The bronchoconstrictive response induced by MDI might be caused by the pro- pellants and/or the other inert ingredients contained in MDIs.