생쥐 대장 카할세포에서 가미소요산, 반하사심탕 및 보중익기탕의 효과에 관한 비교연구

최나리,최우균,김병주 대한한의학방제학회 2024 大韓韓醫學方劑學會誌 Vol.32 No.1

Objectives : The purpose of this study was to examine the effects of insurance herbal medicines on colonic interstitial Cells of Cajal (ICC) in mice. Methods : Among the insurance herbal medicines, we chose Gamisoyo-san (GSS), Banhasasim-tang (BHSST) and Bojungikki-tang (BGIKT). We made the ICC culture in large intestine in mice and used the electrophysiological method to record pacemaker potentials. Also we used MTT assay to check cell viability and examined the ICC protein expression by western blot. Results: 1.GSS (1-10 mg/ml) induced the pacemaker potential depolarization and decreased frequency with concentration-dependent manners in colonic ICC. EC50 is 2.99 mg/ml. BHSST (1-10 mg/ml) induced the pacemaker potential depolarization and decreased frequency with concentration-dependent manners in colonic ICC. EC50 is 2.76 mg/ml. BGIKT (1-10 mg/ml) induced the pacemaker potential depolarization and decreased frequency with concentration-dependent manners in colonic ICC. EC50 is 4.49 mg/ml. 2. GSS, BHSST and BGIKT had no effects on cell viability in colonic ICC. 3. GSS and BGIKT increased the Anoctamin-1 (ANO1) protein expression and BHSST increased the transient receptor potential melastatin-subfamily member 7 (TRPM7) protein expression in colonic ICC. Conclusions : These results suggest that GSS, BHSST, and BGIKT have shown the potential to regulate gastrointestinal (GI) motility by regulating colonic ICC and may show the potential to treat colon-derived GI diseases such as irritable bowel syndrome (IBS).

山茱萸 메탄올 추출물이 편측 경동맥 폐색으로 유도된 생쥐의 허혈성 뇌손상에 미치는 영향

최나리,조성현,이세은,이민지,조수인 대한본초학회 2020 大韓本草學會誌 Vol.35 No.1

Objectives:This study was conducted to evaluate the effects of Corni Fructus, the dried fruits of Cornus officinalis Sieb., on unilateral common carotid artery occlusion (UCCAO) in mouse model. Methods:The Corni Fructus used in the experiment was extracted with anhydrous methanol, then filtered and freeze-dried. C57BL/6 mice used in the experiments were conducted left UCCAO surgery to set up UCCAO rodent model for mice. The mice were divided into five groups for evaluate the effect of methanol extract of Corni Fructus (COM) on UCCAO induced ischemic brain injury. The expression levels of nitric oxide in cerebrum and serum, body weight change were measured. To determine the effect of UCCAO and COM administration on brain neurons, morphological changes of the cerebrum through a microscope was conducted. And western blot was performed to confirm the underlying mechanism of neuroprotective effect of COM administration. Results:COM administered UCCAO groups (CO50, CO150, and CO500) had no significant effects on nitric oxide production in ipsilateral hemisphere proteins and sera. The CO500, 500 mg/kg COM administration, attenuated UCCAO-induced p38 inflammatory signaling pathway and inflammatory mediators such as iNOS and COX-2. The CO500 group showed resilient morphological changes of hippocampus neuronal cells about brain damage caused by decreased flow of blood. These group also showed decreased inflammation and cellular stress response in neuronal cells. Conclusions:From these results, COM has a neuroprotective property via moderating inflammatory factors and cellular stress inducing factors in brain cells.

부모의 과보호적 양육태도와 초기 청소년의 사회적 위축 간의 관계: 정서조절곤란과 자기개념 명확성의 조절된 매개효과

최나리,김희화 한국청소년학회 2022 청소년학연구 Vol.29 No.9

The purpose of this study is to confirm the mediation effect of emotion dysregulation in the relationship where parents' overprotective attitudes affect the social withdrawal of early adolescents, and the moderation effect of self-concept clarity in the relationship between the overprotective attitudes and emotion dysregulation. In addition, it is to examine the moderated mediating effect of self-concept clarity through emotion dysregulation on the relationship between overprotective attitudes and social withdrawal. In this study, 424 middle school students were surveyed and data were analyzed using SPSS 20.0 and PROCESS macro for SPSS 3.5. The findings are as follows; First, emotion dysregulation mediated the relationship between overprotective attitudes and social withdrawal of adolescents. Second, self-concept clarity significantly moderated the relationship between overprotective attitudes and emotion dysregulation. Lastly, the mediating effect of emotion dysregulation was moderated by self-concept clarity in the relation between overprotective attitudes and social withdrawal of adolescents. The limitation of this study and suggestions for future studies were discussed based on above result. 본 연구의 목적은 부모의 과보호적 양육태도와 청소년의 사회적 위축 간의 관계에서 정서조절곤란의 매개효과 및 과보호적 양육태도와 정서조절곤란 간의 관계에서 자기개념 명확성의 조절효과를 밝히는 것이다. 또한, 조절된 매개모형을 통해 자기개념 명확성의 수준에 따라 과보호적 양육태도와 사회적 위축 간의 관계에서 정서조절곤란의 매개효과를 밝히는 것이다. 본 연구에서는 중학생 424명을 대상으로 설문조사를 실시하여 SPSS 20.0과 PROCESS macro for SPSS 3.5를 사용하여 자료를 분석하였다. 분석 결과는 다음과 같다. 첫째, 부모의 과보호적 양육태도가 초기 청소년의 사회적 위축에 정서조절곤란을 통해 간접적인 영향을 미쳤다. 둘째, 자기개념 명확성이 평균 이하인 집단에서 부모의 과보호적 양육태도가 정서조절곤란에 영향을 미쳤다. 셋째, 자기개념 명확성의 수준이 평균 이하인 집단에서 부모의 과보호적 양육태도가 초기 청소년의 정서조절곤란을 통하여 사회적 위축에 미치는 매개효과가 유의하였다. 이러한 결과를 바탕으로 본 연구의 제한점 및 추후 연구에 대한 제언에 관해 논의하였다.

특수교육학개론 강좌에서 경도장애 학생 교육을 위한 보편적 학습설계 적용 탐색

최나리 아시아지적장애인연맹 산하 아시아저널센터 2020 Asia-Pacific Journal of Intellectual Disabilities Vol.7 No.2

As special education is developing, inclusive education is also advancing. The capability of general education teacher is crucial and empowering the pre-service teacher's knowledge and ability in special education is a necessity for inclusive education success. An introductory special education course is the only class about special education field for pre-service general education teachers during their years of college. Thus, pre-service teachers included in this study and they participated universal design for learning activities during the introductory special education course for students with intellectual disabilities or learning disabilities. The students for the class represented the activities in different ways. Thus, the implications for pre-service teachers regarding universal designs for learning are included. 특수교육의 발전으로 통합교육 또한 성장하고 있습니다. 통합교육에서는 일반교사의 역량이 중요한데예비교사부터 특수교육의 자질을 기르는 것이 필요합니다. 특수교육학개론 강좌는 예비교사의 특수교육에 관한 지식을 함양하는 유일한 과목입니다. 따라서, 본 연구는 지적장애 또는 학습장애 학생을 위한내용으로 구성된 특수교육학개론 강좌를 통해 예비교사들은 보편적 학습설계를 적용해보는 활동을 하였습니다. 수강생들은 다양한 방식으로 표현하였습니다. 마지막으로, 예비교사에게 주는 보편적 학습설계의함의도 포함하였습니다.

예비일반교사를 위한 특수교육학개론 강의요목 탐색: 문제행동 및 교육적 실제에 대한 내용을 중심으로

최나리 대구대학교 특수교육재활과학연구소 2022 특수교육재활과학연구 Vol.61 No.1

본 연구는 예비일반교사를 위한 특수교육학개론 강의요목을 탐색하는 것에 목적을 두었다. 예비일반교사가 통합학급 교사에게 궁금한 점을 질문하였는데 특수교육대상자의 문제행동 및 교수와 관련된 내용을 질문하였으며 장애인식과 교육관, 상담, 그리고 학급환경 및 구조에 대해서도 질문을 하였다. 예비일반교사의 질문을 토대로 특수교육학개론의 강의 요목은 어떠한 방식으로 구성되어야 하는지, 그리고 예비일반교사에게 도움이 되는 학습과제에 대하여서도 제언을 하였다.

벨마비 환자에서 아시클로버의 투여 중 발생한 저나트륨혈증

최나리,이정윤,선우준상,권겸일,노학재,안무영,이경복 대한신경과학회 2017 대한신경과학회지 Vol.35 No.3

A 61-year-old woman with chronic kidney disease presented with general weakness and a confused mentality. Two days before admission she had been diagnosed as Bell’s palsy at an outpatient clinic, and started to take oral prednisolone and acyclovir. A blood test at admission revealed hyponatremia (128 mmol/L). After withdrawing acyclovir, her plasma sodium levels began to increase, returning to normal 2 weeks later. This case could provide further evidence for a causal relationship between acyclovir and hyponatremia.

[상상발명, 이런 물건 꼭 있었으면!] 추억을 보여드립니다, 회상TV

최나리 샘터사 2011 월간 샘터 Vol.497 No.-

장애대학생의 교육권 실행 현황: 관련 법령 및 2022 장애인 고등교육지원 종합방안 등의 검토를 중심으로

최나리 대구대학교 특수교육재활과학연구소 2022 특수교육재활과학연구 Vol.61 No.4

The purpose of this study is to examine related laws and 2022 ministry of education plan to support college students with disabilities because covid-19 virus and university entering exam discrimination have influenced those population. To conduct the study, [Special Education Laws for Individuals with Disabilities and Others], [Act on the Prohibition of Discrimination against Persons with Disabilities Remedy against Infringement of Their Rights], [Act on Welfare of Persons with Disabilities], [Higher Education Act], [Act on the Guarantee of Convenience Promotion of Persons with Disabilities, Senior Citizes, Pregnant Women and Nursing Mothers] were reviewed, and the comprehensive plan of higher education for students with disabilities as well as special education support centers in college administration support plan for 2022 were analyzed. Each laws covers providing facilities and prohibiting discrimination against students with disabilities, and the ministry of education request department collaboration by announcing specific plans for students with disabilities. Infrastructure and each members’ collaboration are necessary to implement the laws and 2022 ministry of education plan to support college students with disabilities successfully.

『모비딕』속 시선의 위치가 의미하는 상징성 고찰

최나리 새한영어영문학회 2018 새한영어영문학회 학술발표회 논문집 Vol.2018 No.10

Delayed Surgery for Aortic Dissection after Intravenous Thrombolysis in Acute Ischemic Stroke

최나리,윤지은,박병원,장원호,김현조,이경복 대한흉부외과학회 2016 Journal of Chest Surgery (J Chest Surg) Vol.49 No.5

We report a case of aortic dissection masquerading as acute ischemic stroke followed by intravenous thrombolysis. A 59-year-old man presented with dizziness. After examination, the patient had a seizure with bilateral Babinski signs. Soon after identifying multiple acute infarctions in both hemispheres on diffusion-weighted brain magnetic resonance (MR) imaging, tissue plasminogen activator (t-PA) was administered. Both common carotid arteries were invisible on MR angiography, and subsequent chest computed tomography revealed an aortic dissection. The emergency operation was delayed for 13 hours due to t-PA administration. The patient died of massive bleeding.