수정체의 노화에 따른 단백성분의 산화 : 수정체의 Nucleoschlerosis에 따른 변화

최기오,정영도,양성렬,황태익,안봉한,이민화 한국노화학회 1991 한국노화학회지 Vol.1 No.1

NADPH Oxidase Mediates b-Amyloid Peptide-Induced Neuronal Death in Mouse Cortical Cultures

최기오,남궁경영,황신애,김종근,배춘상 전남대학교 의과학연구소 2017 전남의대학술지 Vol.53 No.3

b-Amyloid peptide (Ab) is the main component of senile plaques in patients with Alzheimer's disease, and is known to be a main pathogenic factor of the disease. Recent evidence indicates that activation of NADPH oxidase (NOX) in microglia or astrocytes may be a source of Ab-induced reactive oxygen species (ROS). We investigated the role of neuronal NOX in Ab-induced neuronal death in mouse mixed cortical cultures. Cell death was assessed by measuring lactate dehydrogenase efflux to bathing media 24 or 48 hr after exposure to Ab25-35, a fragment of Ab with an equivalent neurotoxic effect. Ab25-35 induced neuronal death in concentration- and time- dependent manners with apoptotic features. Neuronal death was significantly attenuated, not only by anti-apoptotic drugs, such as z-VAD-fmk and cycloheximide, but also by antioxidants, such as trolox, ascorbic acid, and epigallocatethin gallate. We also demonstrated that treatment with 20 mM Ab25-35 increased fluorescent signals in mixed cortical cultures, but produced only weak signals in pure astrocyte cultures in the presence of 2’,7’-dichlorofluorescin diacetate (DCF-DA), an indicator for intracellular ROS. Increased DCF-DA fluorescence was markedly inhibited, not only by trolox, but also by selective NOX inhibitors, such as apocynin and AEBSF. Western blot analyses revealed that Ab25-35 increased the expression of gp91phox, a main subunit of NOX in cells. The above antioxidants, apocynin, and AEBSF significantly attenuated neuronal death induced by Ab25-35. Furthermore, the gp91phox-specific siRNA-based knockdown of NOX significantly inhibited neuronal death. These results suggest that activation of neuronal NOX is involved in Ab25-35-induced neuronal death.

사회보장에 관한 헌법 규정의 개정 연혁

최기도(崔基度) 서울대 사회보장법연구회 2020 사회보장법연구 Vol.9 No.1

문재인 대통령이 2018년 3월 제안한 대한민국헌법 개정안은 국회 본회의에서 의결정족수 미달로 사실상 폐기되었다. 그러나 해당 헌법개정안의 제안은 1987년 제9차 헌법 개정 이후 처음 이루어진 것으로서 현행 헌법의 지속가능성에 대한 의문을 공식화하였을 뿐 아니라, 앞으로 언제든지 개헌 논의가 이루어질 수 있음을 시사한다. 사회보장에 관한 헌법 규정의 개정은 사회보장을 둘러싼 헌법현실과 헌법규범의 괴리에 대한 반성적 고찰을 토대로 우리 사회에서 이루어지고 있는 사회보장에 관한 헌법 규정의 개정 논의, 다른 나라의 입헌례, 그리고 사회보장에 관한 헌법 규정의 개정 연혁을 종합적으로 고려하여 이루어진다. 그 중 사회보장에 관한 헌법 규정의 도입 배경·이유에 대한 고찰은 규정에 대한 이해를 깊이 있게 하고, 개정 과정에서의 문제점을 확인할 수 있도록 하여 사회보장에 관한 헌법 규정의 개정 방향에 대하여 중요한 시사점을 줄 수 있을 것이다. 본 글에서는 사회보장에 관한 헌법 규정의 개정 배경을 당시의 자료 등을 통하여 구체적으로 살펴봄으로써 사회보장에 관한 헌법 규정에 대한 개정 과정의 한계를 밝히고 개정 방향에 대한 시사점을 찾는다. 사회보장에 관한 헌법 규정의 개정 연혁에 대한 고찰이 향후 개정 과정에서 반면교사가 될 수 있기를 기대한다. The proposed revision to the Constitution of the Republic of Korea proposed by President Moon Jae-In in March 2018 was virtually abolished due to insufficient legislative meetings at the National Assembly. However, the proposed constitutional revision was first proposed after the ninth constitutional revision in 1987, and it not only formalized the question of the sustainability of the current constitution, but also suggests that discussions on the revision can be made at any time in the future. The revision of the constitutional rules on social security is based on a reflection on the disparity between the reality surrounding social security and the constitutional rules, discussions on the revision of the constitutional rules on social security in our society, comparative study of constitutional rules of other countries, and the consideration of the revision history of the constitutional rules on social security. Among them, in-depth consideration of the reason and background of the introduction and revision of the constitutional rules on social security deepens understanding of the regulations and identifies problems in the revision process. It may give some implications for directions for revision. This article clarifies the limitations of the revision process and suggests directions for revision by examining the background of the revision of the constitutional rules on social security through the constitutional data of the time. It is hoped that review of the revision history of the constitutional rules on social security will become a lesson in the future.

Xanthine Oxidase의 금속촉매산화계에 대한 촉진작용

최기오 全南大醫大 2001 전남의대학술지 Vol.37 No.4

[방위산업] K-방산 르네상스 시대, 미래국방과 방위산업

최기일 월간군사저널 2022 월간군사 Vol.2022 No.7

영국의 국방획득 및 조달 제도에 관한 연구

최기일,이기택,신도균,은근숙 한국방위산업학회 2017 韓國防衛産業學會誌 Vol.24 No.4

This study is a case study on the form of research report analyzing the defense procurement policy and arms procurement system in the UK. The study was carried out with the aim of deriving some implications that could be applied between the defense procurement policies of Korea through the policy acquisition, defense industry related policy, system and organization research in the UK As a European military power, the UK has developed and acquired the core technologies of the defense weapon system. Recently, it has been pursuing defense procurement policies consistently by establishing basic procurement and technical advocacy defense and security strategies. Based on the research on defense acquisition and procurement system of the UK, it can contribute to the development of the acquisition business management field of our military if it is applied to the defense contracts related to domestic defense contracts and defense costs related to defense cost. 본 연구는 영국의 국방획득 정책과 무기체계 조달 관련 제도를 분석한 연구보고 형태의 사례논문이다. 영국의 국방획득과 방위산업 관련 정책, 제도, 조직 관련 연구를 통해 우리나라 방위사업 정책 추진 간에 적용할 수 있는 시사점을 도출하기 위한 목적으로 연구를 진행하였다. 영국은 유럽의 군사 강대국으로서 국방 무기체계 핵심기술을 자체적으로 연구개발하여 획득하였고, 최근에는 공개조달과 기술우위 국방 및 안보전략 기본방침을 수립하여 일관성 있게 국방획득 정책을 추진 중에 있다. 이러한 영국의 국방획득 및 조달 제도에 대한 연구를 바탕으로 국내의 국방계약과 방산원가 관련 방위사업 정책에 활용하여 적용한다면, 우리 군의 획득 사업관리 업무분야 발전에도 이바지할 수 있을 것으로 판단되는 바이다.

전기·전자제품관련 국제환경규제 대상물질별 시험분석방법 개발 동향

최기인(Choi Ki-in),황태웅(Hwang Tae-woong) 한국분석과학회 2009 분석과학 Vol.22 No.6

遠視

崔基仁 세계평화교수협의회 1986 廣場 Vol.153 No.-

중형 폐기물 소각시설에 설치된 습식세정탑 유입 및 유출가스에서의 다이옥신 농도변화

최기인,이동훈,최동혁 한국폐기물자원순환학회 2004 한국폐기물자원순환학회지 Vol.21 No.5

The Study on Estimation of Assembly Efficiency via Diversifying Joinery Techniques for Wooden Furniture -Focused on the Studio Classes of Furniture Design Department of Two Universities in Korea -

최기 한국가구학회 2009 한국가구학회지 Vol.20 No.3

The joinery technique, as one of manufacturing techniques for the wooden furniture, influences the production process, the economic efficiency, and the diversification of design. Especially, the usage of machine tools can determine how much the students can enhance their design expression capabilities during the practice class in furniture design courses of domestic universities, in accordance with whether to utilize the machine tools or not, and how much and frequent to use the machine tools. The study proved that the joinery techniques, based on the high-tech machine, has more efficiencies in the various aspects, including the easiness to manufacture the products, and the diversity of design than the joinery technique, based on the handcraft-only. As the ground of this, this study estimated the time to produce the wooden furniture by machine tools and by handcraft-only, each. Also, this study show the comparison of the features of three different joinery techniques. On the basis of this comparison, this study made the conclusion that the machine-based joinery technique, which is used in the practice class, is the best method to bring the best results in manufacturing the wooden furniture. The joinery technique, as one of manufacturing techniques for the wooden furniture, influences the production process, the economic efficiency, and the diversification of design. Especially, the usage of machine tools can determine how much the students can enhance their design expression capabilities during the practice class in furniture design courses of domestic universities, in accordance with whether to utilize the machine tools or not, and how much and frequent to use the machine tools. The study proved that the joinery techniques, based on the high-tech machine, has more efficiencies in the various aspects, including the easiness to manufacture the products, and the diversity of design than the joinery technique, based on the handcraft-only. As the ground of this, this study estimated the time to produce the wooden furniture by machine tools and by handcraft-only, each. Also, this study show the comparison of the features of three different joinery techniques. On the basis of this comparison, this study made the conclusion that the machine-based joinery technique, which is used in the practice class, is the best method to bring the best results in manufacturing the wooden furniture.