학동기 약시 환아에서 부분 가림치료와 간헐적 아트로핀 처벌치료의 비교

이경숙,채주병,최미영,Kyoungsook Lee,MD,Ju Byung Chae,MD,Mi Young Choi,MD,PhD 대한안과학회 2010 대한안과학회지 Vol.51 No.2

Purpose: To compare the outcome of part-time occlusion therapy and intermittent atropine penalization therapy in amblyopic school-age patients. Methods: In the present study, the authors retrospectively analyzed school-age amblyopic patients treated with part-time occlusion therapy (Group 1) and intermittent atropine penalization therapy (Group 2) as primary treatments. Age, visual acuity (logMAR) and interocular acuity differences at the beginning of treatment, cause of amblyopia, depth of amblyopia, and compliance for treatment were analyzed. Visual acuity and the lines of improvement from baseline visual acuity in the amblyopic eye were compared between the two groups with high compliance. Results: The number of patients was 43 in Group 1 and 23 in Group 2. Age and the baseline visual acuity were not significantly different between Group 1 and Group 2. Group 2 had a higher level of compliance than did Group 1 (91.7; 63.4%), but there was no statistical difference between the groups (p=0.064). The visual acuity (logMAR, 0.27:0.05, p=0.020) and the lines of improvement of the amblyopic eye at the final follow-up (2.7:4.2 lines, p=0.010) were better in Group 1 than in Group 2 with high compliance. Conclusions: In amblyopic school-age children, part-time occlusion therapy could be conducted as primary treatment in cases with high compliance. Intermittent atropine penalization therapy can be attempted if there is low compliance in occlusion therapy. J Korean Ophthalmol Soc 2010;51(2):259-265

유리체절제술과 동시에 시행한 베바시주맙 주사 후 발생한 유리체 그물망

김모세,채주병.Moses Kim. MD. Ju Byung Chae. MD 대한안과학회 2014 대한안과학회지 Vol.55 No.5

Purpose: To report a case of vitreous inflammation (vitreous web) after intravitreal bevacizumab injection accompanying pars plana vitrectomy (PPV) for the treatment of proliferative diabetic retinopathy with vitreous hemorrhage. Case summary: A 41-year-old female who underwent panretinal photocoagulation for diabetes mellitus (DM) retinopathy presented with decreased visual acuity in her right eye which was caused by vitreous hemorrhage. The patient underwent PPV with intravitreal bevacizumab injection. One day after surgery, the vitreous hemorrhage cleared and there was no inflammation in the anterior segment; however, multiple inflammatory white strands (vitreous web) were found in the vitreous cavity. She was diagnosed with non-infectious endophthalmitis and treated with topical steroid and additional oral steroids, resulting in clearance of the vitreous web on postoperative day 4. One month later, vitreous hemorrhage occurred in the other eye. PPV without bevacizumab injection cleared the vitreous hemorrhage with no evidence of vitreous web. Conclusions: Vitreous web-like inflammation can occur after intravitreal bevacizumab injection accompanying PPV for the treatment of DM vitreous hemorrhage. After eliminating infectious endophthalmitis based on lack of pain, conjunctival injection, anterior chamber hypopyon, and inflammatory cells, the web can be cleared without invasive intravitreal antibiotics injections. J Korean Ophthalmol Soc 2014;55(5):780-784

면역저하 환자에서 진균성 대뇌 동맥류를 동반한 안내염 1예

배신우,채주병,Sinwoo Bae,Ju Byung Chae 대한안과학회 2011 대한안과학회지 Vol.52 No.10

Purpose: To report a case of a endogenous <em>Aspergillus</em> endophthalmitis associated with mycotic cerebral aneurysmal rupture. Case summary: A 51-year-old woman was referred to our retina clinic for decreased visual acuity in the left eye. The patient had previously undergone a liver transplant for liver cirrhosis and hepatocellular carcinoma. On fundus examination, vitreous opacities with a yellowish-white subretinal abscess were observed. There were no abnormal findings except the positive sign in the laboratory serum <em>Aspergillus</em> antigen test performed on admission. Based on the suspicion of endogenous endophthalmitis, pars plana vitrectomy was performed with intravitreal antibiotics injection to treat fungal and bacterial infections. There was no growth in either the vitreous or anterior chamber culture. After vitrectomy, visual acuity improved and the inflammation subsided. However, by the three-week follow-up, acute-onset left hemiplegia with a right hemisphere cerebral hemorrhage had occurred. Cerebral magnetic resonance angiography showed multiple mycotic aneurysms characterized by a large and fusiform appearance. The patient was treated with neuro-embolization and was stabilized with minimal sequalae. Conclusions: Although the immunocompromised endophthalmitis patient can be treated using proper management, brain lesions such as mycotic aneurysm may exist and should be carefully considered. J Korean Ophthalmol Soc 2011;52(10):1249-1253

외상으로 인한 안구 내 금속이물 처치에 대한 수술 결과 및 예후인자 분석

김경태,채주병,Kyung Tae Kim,Ju Byung Chae 대한안과학회 2012 대한안과학회지 Vol.53 No.3

Purpose: To investigate the outcome of surgery for a metallic intraocular foreign body and prognostic factors for visual acuity. Methods: A retrospective chart review was performed on 47 eyes of 47 patients who underwent surgical removal of a metallic intraocular foreign body (IOFB) after eyeball laceration between 2000 and 2010. We investigated the location and size of eyeball lacerations, the location of IOFB, the clinical findings at initial examination, surgical methods and best corrected visual acuity. We analyzed the prognostic factors for final visual acuity. Results: The mean age was 45 years, and the most common cause of IOFB was lawnmower use. Cornea (77%) was the most frequently involved structure, and hyphema (72%) was the most common finding at initial slit lamp examination. Retina was the most common site of IOFB. The average visual acuity was 0.17 ± 0.49 before surgery, and the final visual acuity was 0.23 ± 0.39. Good visual prognosis was observed when the initial visual acuity was good or when the IOFB was located in the anterior segment, but the prognosis was poor when there was a vitreous opacity compromised with endophthalmitis at initial examination. Conclusions: An IOFB should be removed as soon as possible. Good initial visual acuity and anterior segment IOFB are good prognostic factors of visual outcome. J Korean Ophthalmol Soc 2012;53(3):460-465

안부대상포진에서 유리체혼탁, 망막출혈 및 시신경병증을 동반한 안병증 1예

김모세,최미영,채주병.Moses Kim. MD. Mi Young Choi. MD. Ju Byung Chae. MD 대한안과학회 2013 대한안과학회지 Vol.54 No.3

Purpose: To introduce a case of complicated ophthalmopathy in herpes zoster ophthalmicus including vitreous opacity, retinal hemorrhage and optic neuropathy having components of anterior ischemic optic neuropathy and optic neuritis. Case summary: A 59-year-old man visited our clinic because of visual disturbance in the right eye which occurred after right facial pain and vesicles. There were inflammatory cells in the anterior chamber, retinal hemorrhage in the retina and vitreous opacity was found. Track-like high signal intensity along the right optic nerve was found on T1 MRI. Partial filling defect of optic disc was observed on fluorescein angiography (FAG). The patient was diagnosed with herpes zoster ophthalmicus complicated by anterior uveitis and optic neuropathy having components of anterior ischemic optic neuropathy and optic neuritis. The patient was started on intravenous acyclovir at a dose of 10 mg/kg every 8 hours for 5 days and Herpesid eye ointment 5 times daily. After the initial treatment, oral acyclovir 400 mg was given 3 times daily for 14 days. Skin symptoms and fundus findings improved but the visual acuity did not improve because of optic atrophy. Conclusions: Ophthalmopathy including anterior uveitis, vitreous opacity, retinal hemorrhage and optic neuropathy having components of anterior ischemic optic neuropathy and optic neuritis should be considered in herpes zoster ophthalmicus patients.

근시안에서 각막 후면의 높이와 관계 있는 인자들

이근장 ( Geun Jang Lee ),채주병 ( Ju Byung Chae ),차흥원 ( Hungwon Tchah ),조범진 ( Beom Jin Cho ) 대한안과학회 2002 대한안과학회지 Vol.43 No.10

일과성 흑암시와 관련된 안과적, 전신적 임상양상 : 6년간 내원 환자 임상고찰

문태환(Tae Hwan Moon),채주병(Ju Byung Chae) 대한안과학회 2015 대한안과학회지 Vol.56 No.5

목적: 일과성 흑암시를 주소로 안과에 초진 내원한 환자들의 원인 질환의 분포 및 빈도, 이와 관련된 안과적, 전신적인 임상 양상에 대해 조사하고자 한다. 대상과 방법: 6년 동안 일과성 흑암시를 주소로 안과에 초진 내원하여 안과 진료 및 경동맥 관련 검사를 받은 모든 환자를 대상으로 후향적으로 의무기록을 분석하였다. 초진 시 시행 받은 안과적 검사 및 흑암시의 원인 조사를 위한 경동맥 관련 검사를 분석하고, 그에 따른 흑암시의 원인 질환 종류 및 질환 빈도, 경동맥 협착 정도를 조사하였다. 결과: 조사기간 중 총 35명이 일과성 흑암시를 주소로 안과에 초진 내원하였다. 환자의 평균나이는 63세였으며, 남자가 27명, 여자가 8명이었다. 29명(82.9%)의 환자에서 단안에 발생하였고, 6명(17.1%)에서 양안에 발생하였다. 당뇨환자는 34.2%, 고혈압환자는 54.3%이었다. 가장 흔한 원인 질환은 망막동맥폐쇄였으며(10명), 그 외에 안허혈증후군(8명), 망막정맥폐쇄(2명), 기타 혈관 관련 질환(4명)이 일과성 흑암시를 유발하였다. 진단된 혈관관련 이상이 없이 일과성 흑암시만 있는 경우는 31.4%(11명)였다. 모든 환자에서 경동맥초음파 검사를 시행하였으며, 경동맥 협착 소견을 보인 환자는 45.7%(16명)였다. 경동맥 협착 소견을 보인 16명 중 6명에서 망막의 혈관폐쇄 관련 질환이 있었으며, 안허혈증후군이 6명, 일과성 허혈성 발작이 2명, 뇌졸중과 심방세동이 각각 1명으로 조사되었다.결론: 일과성 흑암시는 다양한 원인으로 발생할 수 있는 현상이며, 전신적 문제 없이 단순한 발작소견으로 보일 수도 있으나, 심각한 시력저하를 유발하는 망막동맥폐쇄질환이나 안허혈증후군의 초기증상일 수 있으므로, 전신적인 검사를 포함한 철저한 검사가 필요하다. Purpose: To investigate the prevalence of ocular and systemic disease causing amaurosis fugax and to discuss the ocular and systemic manifestation of each disease. Methods: Consecutive patients who had amaurosis fugax were retrospectively studied from 2007 to 2013. Carotid evaluation us-ing Doppler was performed in all patients. Ocular and medical histories were taken and bilateral ophthalmic evaluation performed. Results: This study included 35 patients. The mean age of patients was 63 years and 27 patients were male; 29 unilateral and 6 bilateral eyes were involved. Associated systemic disease included hypertension (54.3%) and diabetes mellitus (34.2%). The most frequent cause of amaurosis fugax was retinal artery occlusion (28.6%) followed by ocular ischemic syndrome (22.9%), other vascular diseases (11.4%), and retinal vein occlusion (5.7%). The remaining 31.4% patients with amaurosis fugax had no vascular disease. Clinically significant stenosis of the internal carotid artery was observed in 16 patients (45.7%) and 6 of these patients (37.5%) had retinal artery occlusion disease. Conclusions: Prevalence and clinical manifestation of amaurosis fugax is very complex. Patients with transient visual dis-turbance are at risk for retinal artery occlusion, ocular ischemic syndrome and other diseases which cause visual loss. Therefore, careful history taking and urgent systemic and ophthalmic evaluations should be performed. J Korean Ophthalmol Soc 2015;56(5):732-736

영지버섯 균사체 (Ganoderma lucidum IY009)로부터 추출한 단백다당체의 항암활성

백성진(Seong Jin Baek),김용석(Yong Seok Kim),용환미(Hwan Mee Yong),채주병(Ju Byung Chae),윤환민(Hwan Min Yun),박동우(Dong Woo Park),김동연(Dong Yeon Kim),이정옥(Jeong Ok Lee),이준우(June Woo Lee),박승국(Seung Kook Park) 대한약학회 2001 약학회지 Vol.45 No.6

In this study, the antitumor activities were investigated using β-Immunan, a proteoglycan obtained from cultured mycelia of the IYO09 strain of Ganoderma lucidum IY009belonging to basidiomycetes. The result showed the significant effect of cytotoxicity test against murine sarcoma 180 and murine Iymphocytic leukemia L1210 using immunized macrophage cultures by β-Immunan. When intraperitoneally injected at 40 mg/kg/day daily for 10 days, β-Immunan inhibited the growth of sarcoma 180 solid tumor in ICR mice by 88.8% (p<0.05). It was also observed that β-Immunan increased life span by 85.2% (p<0.01) after treatment of 100 mg/kg/day in BDFI mice bearing Iymphocytic leukemia L1210. And combination therapy with cisplatin (dosage: 4 mg/kg) increased life span by 140.4% (p<0.05) after treatment of 100 kg/mg/day in BDFI mice bearing Iymphocytic leukemia L1210.

영지버섯 균사체 ( Ganoderma lucidum IYO09)로부터 추출한 단백다당체의 전이암 억제 효과

백성진(Seong Jin Baek),김용석(Yong Seok Kim),용환미(Hwan Mee Yong),채주병(Ju Byung Chae),이선애(Sun Ae Lee),배우철(Woo Chul Bae),박동우(Dong Woo Park),김동연(Dong Yeon Kim),이준우(June Woo Lee),박승국(Seung Kook Park) 대한약학회 2002 약학회지 Vol.46 No.1

β-Immunan, a proteoglycan, was isolated from the mycelium of Ganoderma lucidum which belongs to a medicinal mushroom. The effects of β-Immunan on cell- cell and cell-matrix interactions mediated by carbohydrate-recognition and the mechanism responsible for the inhibition of experimental metastasis of Bl6-FIO and B16/BL6 murine melanoma were studied. The results showed that Ganoderma lucidum-Immunan inhibited Bl6-Fl melanoma cell's adhesion to laminin and asialofetuin-induced homotypic aggregation and reduced invasion against Bl6-FIO murine melanoma cells through matrigel in vitro assay: When β-Immunan was intraperitoneally administrated to C57BL/6 mice bearing B16/BL6 murine melanoma cells, it was decreased the number of pulmonary metastatic colony by the dose dependent manner ranging from 20 to 100 mg/kg/day, The results indirectly indicate that clinical treatment with β-Immunan might be expected to exhibit anti-metastatic effect. In the put-monary metastasis, the number of pulmonary metastatic colony of melanoma when β-Immunan was intraperitoneally aduunistrated to C57BL/6 mice bearing Bla/BL6 murine melanoma cells by intravenous injection were decreased by the dose dependent manner ranging from 20 to 100 mg/kg/day.

안면부 대상포진 이후 발생한 다발성 장액성 맥락망막병증 1예

현상윤(Sang Yoon Hyun),김동윤(Dong Yoon Kim),채주병(Ju Byung Chae) 대한안과학회 2016 대한안과학회지 Vol.57 No.1

Purpose: To report a case of multiple serous chorioretinopathy after facial herpes zoster. Case summary: A 48-year-old male visited our clinic due to visual disturbance in the left eye which occurred 3 days after left facial pain and vesicles. Chemosis and multiple serous retinal detachments were found. The patient was diagnosed with multiple serous chorioretinopathy due to herpes zoster virus and was started on intravenous acyclovir at a dose of 10 mg/kg every 8 hours for 9 days and herpes eye ointment 5 times daily. After the initial treatment, oral prednisolone 60 mg was given daily for 6 days. Skin lesions were cleared, and abnormal fundus and visual acuity improved after treatment. Conclusions: Ophthalmopathy including multiple serous chorioretinopathy should be considered in managing herpes zoster ophthalmicus patients