승마 추출물의 항알레르기 효과

신태용(Tae Yong Shin),서형만(Hyung Man Seo),채병숙(Byeong Suk Chae) 대한약학회 1998 약학회지 Vol.42 No.4

Effects of the aqueous extract of Cimicifuga heracleifolia (CHAE) on the allergic reactions were investigated. CHAE inhibited systemic anaphylaxis induced by compound 48/80 in mice dose-dependently. Especially, CHAE inhibited compound 48/80-induced systemic anaphylaxis 100% with a dose of 0.5mg/g body weight. CHAE significantly inhibited serum histamine levels induced by compound 48/80. CHAE inhibited histamine release from the rat peritonea] mast cells activated by compound 48/80 or anti-DNP IgE. Our studies provide evidence that CHAE will be beneficial in the treatment of anaphylias.

암유발생쥐에서 리포폴리사카라이드에 의해 유도된 사이토카인의 생산에 미치는 염화아연의 영향

채병숙(Byeong Suk Chae) 대한약학회 2001 약학회지 Vol.45 No.5

To determine effects of zinc on lipopolysaccharide (LPS)-induced production of proif1am-matory cytokines and Iymphokines in tumor-bearing ICR mice, this study has been investigated. Zinc chloride (Zn) at doses of 1 mghg was administered orally 30 minutes before I.p. injection of LPS (8 mg/kg) 5 times for 7 days. LPS greatly increased tumor necrosis factor (TNF)-α and interleukin (IL)-1β, in both serum and splenic supernatants compared with those in controls. Howeverl Zn strongly decreased Lpsincreased production of TNF-α and IL-lβ in spleenic supernatants compared with those in controls and insignificantly also reduced in serum. LPS insignificantly decreased IL-2 levels in splenic supernatants compared with those in controls but significantly increased interferon (IFN)-γ. Levels. Zn didn't affect IL-2 production in splenic supernatants compared to controls but significantly enhanced the LPS- decreased production of IL-2. Zn significantly increased IFN-γlevels in splenic supernatants compared to controls and did not affect the LPS-increased production of IFN-γ. These findings suggest that Zn may strongly attenuate the LPS-induced pathogenesis of proinf1ammatory crtokines in tumor-bearing state and significantly up-regulate the LPS-induced function of T cells to produce IL-2 with maintaining normally the LPS-increased levels of IFN-γ.

리포포리사카라이드의 세포성 면역반응에 미치는 스와인소닌의 영향

채병숙(Byeong Suk Chae),안영근(Young Keun Ahn),김정훈(Joung Hoon Kim) 대한약학회 1998 약학회지 Vol.42 No.1

Effects of swainsonine (SW: 8alpha, beta-indolizidine-1alpha, 2alpha, 8beta-triol from Locoweed) on the cellular and nonspecific immune responses of lipopolysaccharide (LPS) were studied in ICR mice. Mice were divided into 4 groups (10mice/group), and LPS was given to each mouse 1 hr after i.p. injection with 3.7mg/kg of SW by i.p. injection twice a week for 14 days at a dose of 2mg/kg. Immune responses of the delayed-type hypersensitivity response (DTH) to sheep red blood cells (s-RBC), phagocytic activity and natural killer (NK) cell activity were evaluated. LPS treatment didn`t affect NK cell activity, phagocytic activity, DTH to s-RBC compared with those in controls, and phagocytic activity of sareoma 180 tumor bearing mice. However, circulating leukocytes were significantly decreased. Combinaton of LPS and SW increased circulating leukocytes significantly compared vath that in LPS alone, and DTH to s-RBC, NK cell activity and phagocytic activities of normal and sarcoma tumor bearing mice were not affected. These findings indicate that SW didn`t affected the cellular immune responses suppressed by LPS but significantly increased circulating leukocytes.

RAW 264.7 Cell에서 리포폴리사카라이드로 유도된 염증성 매개인자들의 생산에 있어서 Corticosterone 전처리 효과

채병숙(Byeong Suk Chae) 大韓藥學會 2015 약학회지 Vol.59 No.5

Glucocorticoids are known to have anti-inflammatory effect. To investigate whether corticosterone pre-treatment enhances or not lipopolysaccharide (LPS)-induced production of inflammatory mediators, RAW 264.7 cells were pretreated with various concentrations of corticosterone for 24 h and then cultured without corticosterone in the presence or absence of LPS. Our results demonstrated that LPS remarkably increased production of TNF-α, IL-6, IL-1β, vascular endothelial growth factor (VEGF), and NO (nitric oxide). Corticosterone pretreatment significantly attenuated LPS-induced production of TNF-α, IL-1β, and VEGF, while significantly enhanced IL-6 and NO. These findings suggest that cor-ticosterone pretreatment may contribute to LPS-induced inflammatory responses in macrophages via pro- and anti-inflam-matory imbalance of inflammatory mediators.

호텔 일식당 메뉴관리와 레스토랑 이미지가 고객만족 및 재방문의도에 미치는 영향에 관한 연구

채병숙(Chae Byung Sook),조춘봉(Cho Chun Bong),최웅(Choi Woong) 한국외식경영학회 2007 외식경영연구 Vol.10 No.4

Generally, hotel consists of rooms, lobby, lounge, shops and many restaurants. Restaurants of these are the important resource to get the hotel's managerial performance. Japanese restaurants has been particularly noted for getting high hotel image. Because of that, japanese restaurants have played a leading role in customer satisfactions and repurchase intention which created images of the hotel, this study execute the menu management and restaurant's physical evidence image of japanese restaurants managements. As the results of this study, menu managements and restaurant images lead the japanese restaurant users satisfaction and cause customers to bring repurchase intention. This study contributes to the sales activation by applying it to the menu and image management of the japanese restaurant in a hotel.

저용량 corticosterone로 전처리된 RAW 267.4 cells과 Hepa1c1c-7 cell에서 LPS로 유도된 염증성 매개인자들의 생산에 있어서 baicalin의 영향

채병숙(Byeong Suk Chae) 대한약학회 2022 약학회지 Vol.66 No.1

Low-dose glucocorticoids (GCs) are known to induce inflammation and immunosuppression. However, whether preconditioning with a low dose of GCs induces hepatic inflammation remains unclear. Although baicalin has beneficial therapeutic activity against liver damage, 100 μM baicalin enhances the lipopolysaccharide (LPS)-induced production of inflammatory acute-phase proteins in Hepa1c1c-7 cells. This study was performed to investigate the effect of 100 μM baicalin on the LPS-induced production of inflammatory mediators in liver cells, including Kupffer cells and hepatocytes, pre-conditioned with a low dose of GCs. RAW 267.4 cells and Hepa1c1c-7 cells were pretreated with 50 (cort 50) or 100 ng/mL (cort 100) corticosterone for 24 h and then cultured with 100 μM baicalin in fresh complete medium in the presence of LPS. Our results demonstrated that baicalin markedly decreased the LPS-induced production of TNF-α, IL-6, IL-1β, and nitric oxide in RAW 267.4 cells. Baicalin also strongly attenuated the LPS-induced production of TNF-α in cort 50- and cort 100-pretreated RAW 267.4 cells. Baicalin significantly upregulated the production of IL-6 induced by LPS and the production of VEGF decreased by LPS, but decreased the LPS-induced production of CRP in cort 100- pretreated Hepa1c1c-7 cells compared to untreated Hepa1c1c-7 cells. In conclusion, these findings suggest that 100 μM baicalin may enhance the LPS-induced production of inflammatory acute-phase proteins in hepatocytes, whereas it may downregulate these protein levels in macrophages and Kupffer cells. Moreover, preconditioning with a low dose of corticosterone may prime the effects of 100 μM baicalin on the LPS-induced production of IL-6 in hepatocytes, leading to hepatic insulin resistance or fatty liver disease.

골프리조트 조리종사자의 근무환경이 직무만족에 미치는 영향

채병숙(Chae, Byoung-Sook),신왕선(Shin, Wang-Seon) 한국외식산업학회 2015 한국외식산업학회지 Vol.11 No.4

과량의 아연에 노출된 생쥐의 사이토카인 생산에 미치는 인도메타신의 영향

채병숙(Byeong Suk Chae),신태용(Tae Yong Shin) 대한약학회 2002 약학회지 Vol.46 No.4

Zinc plays an important role in immunobiological responses, while excessive Binc attenuates immune aulctions in a dose-dependent manner Zinc excess has been reported to increase levels of plasma prostaglandin I s (PGE2), which is known to inhibit production of Th (helper T) 1-associated cytokines and to induce inf1ammatory responses. Thus, this study was investigated the effects of indomethacin, a potent inhibitor of PGE2 synthesis, on the proinf1ammatory cytosine and Iymphokine production in ICR mice exposed to excessive zinc. Indomethacin at doses of 5 mg/kg was administered I.p. 30 minutes before zinc chloride (Zn) 30 mg/kg orally daily for 10 days. Excessive Zn remarkedly increased tumor necrosis factor (TNF)-α and interleukin (IL)-1β Levels in both serum and splenic supernatants compared with those in ontrols, while indomethacin significantly reduced the excessive Zn-induced levels of IL-1β. In serum, excessive Zn significantly decreased the levels of IL-2 and interferon (IFN)-γ compared with those in controls, whereas indomethacin significantly enhanced the excessive Zn-decreased levels of IFN-γ but did not affect the Zn-decreased levels of serum IL-2. In splenic supernatants, All of excessive Zn, indomethacin, and combination of Zn and indomethacin significantly enhanced IL-2 levels compared with those in controls, but indomethacin didn't affect the Zn-induced production of IL-2. These data, therefore, suggest that indomethacin significantly attenuated the in vivo and ex vivo IL-lβ production increased by excessive zinc and remarkedly enhanced the in vivo excessive zinc-suppressed production of IFN- γbut not IL-2.

전문대학교 조리관련학과의 국가직무능력표준(ncs)을 적용한 교육과정 개발에 관한 연구

채병숙(Chae, byoung-sook) 한국외식산업경영학회 2017 외식산업경영연구 Vol.13 No.1

This study is a case of revising the courses for courses in specialty courses in the professional colleges by applying the methodologies for developing the NCS based curriculum. The college curriculum has been approached in view of the need to focus on enhancing student competence based on NCS. Based on the results of the study, two tasks were derived from the Korean food chef and food chef, cook and cook based on the results of the survey, analysis of the needs of students, students and industry personnel and the NCS classification system. The relevant NCS capabilities of the relevant NCS capabilities were derived and reflected in the reform process. The NCS-based curriculum for dining out cooking courses has provided an education-based educational foundation that prepares students to fulfill their duties and competences. The site of the NCS capacity unit (element) and the teaching of teaching materials to be taught will be helpful in facilitating the preparation of students in the field of dining and performing tasks.

염화아연의 체액성 면역독성에 미치는 황기 추출물의 효과

채병숙(Byeong Suk Chae),임종필(Jong Pil Lim),신태용(Tae Yong Shin),전훈(Hoon Joen),김정훈(Joung Hoon Kim) 대한약학회 2000 약학회지 Vol.44 No.1

Effects of Astragali radix extract (AG) on the humoral immunotoxic responses of zinc chloride (Zn) were studied in ICR mice. Mice were divided into 4 groups (10mice/group), and Zn was given to the mice, 1hr after I.p. injection with 0.5g/kg of AG, by I.p. injection daily for 10 days at a dose of 25mg/kg. Mice were immunized and challenged with sheep red blood cells (SRBC). Zn treatment increased the relative weight of spleen compared with those in controls, but decreased the hemagglutination (HA) titer, 2- mercaptoethanol-resistant HA (MER-HA) titer and splenic plaque forming cells (PFC). AG treatment significantly increased the relative weight of spleen, HA titer and PFC compared with those in controls. Combination of Zn and AG significantly increased the relative weight of spleen compared with those in controls,but decreased the HA titer, MER-HA titer and PFC. The relative weight of spleen was significantly increased in the Zn and AG combination group than those in Zn alone treatment group. But the HA titer,MER-HA titer and PFC were slightly increased in the group of combination. These results suggest that AG might slightly restore humoral immune responses lowered by an excess of zinc.