http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Regioselective Synthesis of the FXR Antagonist E-Guggulsterone from Three Natural Steroids
진정욱,한동엽,원동환,조성진,김경희,함정엽,강헌중 대한화학회 2017 Bulletin of the Korean Chemical Society Vol.38 No.5
In our attempt to develop a method to synthesize E- and Z-guggulsterones [antagonists of farnesoid X receptor (FXR)], we have succeeded in synthesizing E-guggulsterone selectively from three steroids, viz, 4-androsten-3, 17-dione (2), 5-androsten-3β-ol-17-one (DHEA) (3), and testosterone (4), in 68, 86 and 62% overall yield, respectively. We also investigated the biological effects of the synthetic E- and Z-guggulsterones and found that E-guggulsterone was more potent than Z-guggulsterone in inhibiting FXR transactivation
위정욱 ( Jeong Ook Wi ),진남철 ( Nam Chul Jin ),한의령 ( Eui Ryoung Han ),윤병조 ( Byung Jo Yoon ),박상훈 ( Sang Hun Park ),고영일 ( Young Ll Koh ) 대한천식알레르기학회 2010 천식 및 알레르기 Vol.30 No.4
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a drug hypersensitivity syndrome characterized by fever, skin rash, blood eosinophilia and multiple organ involvements including liver and kidney developed following drug administration. Vasculitis could be infrequent one of manifestations of DRESS syndrome. Mortality rate of DRESS syndrome is at least 10%. Here, we reported a case of DRESS syndrome with vasculitis. A 67-year-old man with essential hypertension presented with fever and maculopapular rash after being given allopurinol over 2 weeks for gout. He had severe oral mucositis. He had peripheral blood eosinophilia and abnormal hepatic and renal functions. A skin biopsy showed leukocytoclastic vasculitis. Gastroduodenoscopy showed spontaneous mucosal oozing in mid-to-lower esophagus. He was diagnosed as having DRESS syndrome with vasulitis. Allopurinol was stopped and systemic corticosteroid was administrated. His clinical manifestations improved gradually. However, he died of sudden onset of massive intracranial hemorrhage. The case suggests that DRESS syndrome could sometimes present manifestations of vasculitis, which might be fatal. (Korean J Asthma Allergy Clin Immunol 2010;30:320- 324)