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간장 ( 肝臟 ) 및 담도 ( 膽道 ) : Yttrium - 90와 Iodine - 131 Radioimmuno - Globulin을 이용한 간암치료에 대한 실험적 연구
주상언(Sang Aun Joo) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.2
N/A Therapeutic trials were performed on the HepG2 human hepatoblastoma implanted s.c. in the athymic nude mouse. Animals were treated with polyclonal and monoclonal antiferritin and control antibodies labeled with either Iodine-131 or Yttrium-90. Administration of 400 uCi of Y-labeled polyclinal antiferritin or 300 uCi of Y-labeled polyclonal antiferritin significantly increased survival (p<0,001). There were no tumor cures with radiolabeled polyclonal antibody. Animals treated with 200 or 300 uCi of I -labeled monoclonal antiferritin did not show increased survival compared to controls. Monoclonal antiferritin labeled with 'Y significantly prolonged survival of animals (p <0. 001) at doses of 100, 200 or 300 uCi compared with untreated controls. Fifty percent of the animals treated with 200 uCi and 75% of the animals treated with 300 uCi showed no evidence of disease at 140 days following treatment. Four hundred uCi of 'Y-labeled monoclonal antibody proved toxic to the animals. Increased survival was accompanied by a decrease in tumor mitotic rate and an increase in cellular polymorphism as determined by pathological examination. The radiation dose absorbed in the tumor reveals that monoclonal antiferritin antibody to Y deposits 8.4 times than does rabbit polyclonal antiferritin labeled in an identical manner and 7.3 times than dose delivered by the same antibodies labeled with I .
식도 정맥류 출혈에 대한 내시경적 경화요법의 장기적 평가
주상언,기춘석 한양대학교 의과대학 1990 한양의대 학술지 Vol.10 No.1
Chronic progressive liver diseases, such as liver cirrhosis, eventually cause portal hypertension and hepatic coma, and among the cause of death from upper gastrointestinal bleeding variceal bleeding includes intravenous vasopressin infection, insertion of Balloon tamponade, administration of somatotatin, propranolol, and shunt operation, but the effect has not been promising. Endoscopic infection sclerotherapy (EIS) has been shown to be the most effective, simple and safe method. Thus, this method has been accepted widely as a standard treatment of bleeding in the esophageal varices. However, there are still many controversies about long-term survival rate, and there's no standard data about it in Korea. The present study was performed to follow up and estimate the effect of EIS for 119 patients (391 cases) from Oct. over 1981 to July 1987. 1) EIS was done in 100 patients who had variceal bleeding during hospitalization: bleeding was controlled in 91%, 59% was controlled with 1st trial. 2) 39 patients (33.6%) experienced rebleeding after EIS; most common in 6 month. (74%), episode of rebleeding was once in 19 cases. 3) The disappearance rate of varices after repeated EIS ws 56.5% respectively. 4) Main complications were chest pain & discomfort(64.4%), tachycardia(36.3%), fever(28.4%), esophageal ulcer(1.28%), esophagela stricture(0.77%), and pneumonia(0.77%) in order of frequency. 5) The survival rates of all patients were 77.6% in 6 month and 48.6% in 5 year; according to Child's classification, 96.8% and 79.1% of each in group A, 83.5% in group B, 47.5% and 12% in group C. 6) 42 patients (35%) were dead; according to Child's classification, 4 in group A, 17 in group B, 21 in group C. The cause of death were recurrent bleeding (66.7%) and hepatic failure(28.6%). We could conclude that EIS should be the primary therapy for variceal bleeding, and therapy should be aimed to preserve and improve liver function to increase the long-term survival. EIS is thought to be effective in controlling acute variceal bleeding, preventing rebleeding, and improving the survival of the patient.
장린,주상언,정인식,박수헌,김성국,최석렬,송근암,함기백,이용찬,김현수,김태년,최석채,설상영,유종선,김동준,이진,최호순,이정은,송근석,문병석 대한소화기내시경학회 2007 Clinical Endoscopy Vol.34 No.6
Background/Aims: This randomized, double-blind, phase III, multicenter trial was carried out to compare the efficacy and safety of revaprazan, a novel acid pump antagonist, with that of omeprazole in patients with more than one of gastric ulcers. Methods: Two hundred and ninety two subjects were randomized to 4∼8 weeks of treatment with either revaprazan 200 mg or omeprazole 20 mg. The primary efficacy parameter was the cumulative healing rate determined by endoscopy after 4 and 8 weeks of treatment, and the secondary efficacy parameter was an improvement rate of pain. Results: The intention-to-treat analysis revealed revaprazan and omeprazole to have similar cumulative healing rates (93.0% and 89.6%, respectively; p=0.3038). The per-protocol analysis revealed revaprazan and omeprazole to also have similar cumulative healing rates (99.1% and 100%, respectively; p= 0.3229). In both analyses, there were no significant differences in an improvement rate of pain between the two groups. Both drugs were well tolerated. Conclusions: Revaprazan has similar efficacy to omeprazole in the treatment of patients with gastric ulcer with a once a day application of revaprazan 200 mg or omeprazole 20 mg over a 4 to 8-week period. In terms of safety, revaprazan was well tolerated. (Korean J Gastrointest Endosc 2007;34:312-319)
식도정맥류 출혈에 대한 내시경적 경화요법의 장기적 평가
기춘석,주상언 대한소화기내시경학회 1989 Clinical Endoscopy Vol.9 No.2
Chronic progressive fiver diseases, ouch as liver cirrhosis, eventually cau portal hypertension hepatic coma, and among the cause of death from UGI bleeding variceal bleeding secondary to portal hypet-tension is the most common, aver 50%. Glinial management for variceal bleeding includes IV vsopressin injection, insertion of Balloozy tarnporiade, administration of somatosstin or propranolol, ad shunt operation, taut the effect has not been promising. Endoscppic injection sclerotherapy (EIS) has been shown o be the most effective, simple and safe method. Thus, this method has been: accepted widely as a standard treatment of bleeding esophageal varices. However, there are still many controversies about long-tem survival rate, and there's no standard data about it in Korea. The present study was performed to follow up and estimte the effect of EIS for 119 patients (391 cases) from (Jct. 1981 to July 19i;7. 1) EIS was done in 100 patients who had variceal bleeding during hospitalisation; bleeding was controled in 91�6' 59% was controld with 1st trial. 2) 39 patients (33.6%) experineed rebleeding after EIS; most common in 6 month: (74%), episode of rebleedin was once in 19 cases, 3) The disappearance rate of varices after repeated EIS was 56.5%. 4) Main complications were chest pain & discomfort (64.10, tacltycardia (36:39b), fever (28.4%), esophageal ulcer (1.28%) esoph'geal stricture (0.77%), and Gneumonia (0.77%) in order of frequency. 5) The survival rates of all patients were 7?.6 in fi month and 48.690 in 5 year according to Child s classification, 96.8% and 79.19n of eaclj in group A, 83.56 and 83.5% in group B, 47 .5% and 12% in group C. 6) 42 patients (35%) were dead: according to Child's classification, 4 in gtoup A, 17 in graup B, 21 in group C. The cause of death were recurretaf bleedfn8 (66.7%) and heps;tic failure Z8,'.). We could conclude that EIS should be tt primary therapy for varieeal bleeding, and therapy should be aimed to preserve and improve liver function to increase long.term survival. EIS is thought to be effective in cantrollitg acute variceal bleeding, preventing rebleeding, and improihg the survival of the patient.