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In vitro 동물세포에서 GGEx18의 ethyl acetate 분획물에 의한 지방산 B-산화효소 유전자 발현의 조절
주병수 ( Byung Soo Joo ),이희영 ( Hee Young Lee ),이혜림 ( Hye Rim Lee ),윤미정 ( Mi Chung Yoon ),서부일 ( Bu Il Seo ),김범회 ( Beom Hoi Kim ),신순식 ( Soon Shik Shin ) 대한본초학회 2012 大韓本草學會誌 Vol.27 No.2
Objectives:This study was undertaken to investigate the effects of the GGEx18 ethyl acetate fraction (EF) on lipid accumulation and gene expression of fatty acid-oxidizing enzymes using 3T3-L1 adipocytes, C2C12 skeletal muscle cells, and NMu2Li liver cells. Methods:PPARa, AMPK and UCPs transactivation was examined in NMu2Li hepatocytes, C2C12 myocytes, and 3T3-L1 preadipocytes using transient transfection assays. Results: 1. Compared with control, EF significantly increased the mRNA expression of VLCAD in 3T3-L1 adipocytes. 2. Compared with control, EF (0.1 ug/ml) significantly inhibited lipid accumulation in 3T3-L1 adipocytes. 3. EF significantly increased the mRNA expression of AMPKa1, AMPKa2 and PPARa in C2C12 skeletal muscle cells compared with control. 4. EF significantly increased the mRNA expression of genes involved in fatty acid b-oxidation, such as thiolase, MCAD, and CPT-1 in C2C12 skeletal muscle cells compared with control. 5. EF significantly increased the mRNA expression of UCP2 involved in energy expenditure in C2C12 skeletal muscle cells compared with control. 6. Compared with control, EF (10 ug/ml) significantly inhibited lipid accumulation in C2C12 skeletal muscle cells. 7. EF (10 ug/ml) significantly increased the mRNA expression of ACOX, HD, VLCAD and MCAD in NMu2Li liver cells compared with control. Conclusions:These results suggest that EF may prevent obesity by increasing the mRNA expression of mitochondrial fatty acid b-oxidizing enzymes in 3T3-L1 adipocytes, by not only regulating the fatty acid oxidation through activation of AMPK and PPARa, but also increasing the UCP2 mRNA expression in C2C12 skeletal muscle cells, and by stimulating the mRNA expression of fatty acid-oxidizing enzymes in NMu2Li liver cells.
이윤수 ( Yun Su Lee ),송갑득 ( Kap Duk Song ),주병수 ( Byung Su Joo ),이상문 ( Sang Mun Lee ),최낙진 ( Nak Jin Choi ),이덕동 ( Duk Dong Lee ),허증수 ( Jeung Soo Huh ) 한국센서학회 2004 센서학회지 Vol.13 No.2
N/A Optical fiber sensors have been used to detect small amounts of chemical species. In this work, a new thin polymer-clad fiber sensor is developed. Polyaniline is chemically synthesized and thin clad layers of the polymer are easily deposited on optical fiber by dip-coating technique. The optical property of polyaniline as a sensing material is analyzed by UV-Ms-NIR. The light source is stabilized He-Ne laser at635 nm wavelength with 1 mW power. The light power transmitted through the optical fiber is measured with a spectrophotometer. By selecting a fixed incident angle, variation of transmitted light intensity through the optical fiber can be detected as gas molecules absorbed in the polyaniline clad layer. Among the various gases, the fabricated optical fiber sensor shows good sensitivity to NH3 gas. The optical fiber sensors was shown more improved properties than polymer based sensors which measure conductivity changes.
최낙진 ( Nak Jin Choi ),반태현 ( Tae Hyun Ban ),곽준혁 ( Jun Hyuk Kwak ),임연태 ( Yeon Tae Lim ),주병수 ( Byung Su Joo ),김재창 ( Jae Chang Kim ),허증수 ( Jeung Soo Huh ),이덕동 ( Duk Dong Lee ) 한국센서학회 2004 센서학회지 Vol.13 No.3
N/A Thin film gas sensor based on tin oxide was fabricated and its characteristics were examined: Target gas is acetonitrile (CH₃CN) that is simulant gas of blood agent gas. Sensing materials are SnO₂, SnO₂/Pt, and (Sn/Pt)oxidation with thickness from 1000 Å to 3000 Å. Sensor was consisted of sensing electrode with interdigit (IDT) type in front side and a heater in back side. Its dimension was 7 x 10 x 0.6 mm². Fabricated sensor was measured as flow type and monitored real time using PC. The optimal sensing material for CH₃CN was {Sn(3000 Å)/Pt(30 Å)}oxidation and its sensitivity and operating temperature were 30%, 300℃ in CH₃CN₃ ppm.
전도성 고분자 센서 어레이를 이용한 휘발성 유기 화합물 가스 인식
이경문,주병수,유준부,황하룡,이병수,이덕동,변형기,허증수 한국센서학회 2002 센서학회지 Vol.11 No.5
휘발성 유기 화합물 가스(Volatile Organic Compounds)를 인식하고 분석하기 위하여 전도성 고분자 센서어레이를 이용한 시스템을 제작하였다. Polypyrrole와 Polyaniline을 화학중합법으로 센서에 전도성고분자막을 형성하였고 이를 통해 VOC 검지용 센서 어레이를 제작하였다. 센서어레이로부터 측정되는 다차원 데이터는 주성분분석법(PCA)과 RBF(Radial Basis Function Network)을 이용하였다. 제안된 시스템으로 VOCs 가스를 인식하는데 있어서 RBF Network이 PCA방식보다 더욱 효율적인 것으로 판단되었다. We fabricated gas recognition system using conducting polymer sensor array for recognizing and analyzing VOCs(Volatile Organic Compounds) gases. The polypyrrole and polyaniline thin film sensors which were made by chemical polymerization were employed to detect VOCs. The multi-dimensional sensor signals obtained from the sensor array were analyzed using PCA(principal component analysis) technique and RBF(radial basis function) Network. Throughout the experimental trails, we confirmed that RBF Network is effective than PCA technique in identifying VOCs.
최낙진,심창현,송갑득,주병수,이윤수,이상문,이덕동,허증수 한국센서학회 2002 센서학회지 Vol.11 No.5
단일 기판위에 온도측정용 Pt 박막과 Pt 히터 그리고 가스 감지를 위하여 순수한 SnO_2 박막과 Pt가 첨가된 SnO_2박막을 설계하고 제작하였다. 제작된 소자는 실내환경가스인 이산화탄소, 프로판 그리고 부탄의 분류에 응용되었다. 동작 온도를 가변하기 위하여 히터의 입력 전압을 사다리꼴로 인가하면서 SnO_2 감지막의 반응특성과 실내환경가스들에 대한 분류여부를 조사하였다. 감지막 반응특성곡선에서 여러 변수들을 추출한 후 주성분분석(principal component analysis : PCA)을 통하여 가스 분류 특성을 검증하였다. Two SnO_2 based sensing films(pure SnO_2 and SnO_2/Pt) and a Pt thin film for temperature sensor on an alumina substrate were designed and fabricated for classifying the indoor environmental gases. By controlling the heating power in the shape of trapezoid, unique four sensing response curves created from both SnO_2 film and SnO_2/Pt film. Then, various parameters were extracted from sensing response curves and carried out principal component analysis(PCA). The results confirm that a sensor array with the proposed operating mode was extremely effective in classifying indoor environmental gases such as CO_2, C_3H_8, C_4H_10.
송갑득,박영일,이상문,이윤수,최낙진,주병수,서무교,허증수,이덕동 한국센서학회 2002 센서학회지 Vol.11 No.6
센서의 안정도와 감도를 개선시킬 수 있는 단일전극을 가진 열선형 마이크로 가스센서를 제작하였다. 일반적으로, 금속산화물 반도체를 이용한 가스센서는 히터전극과 감지전극의 두 개의 전극을 가지고 있다. 제작된 센서는 히터전극위에 감지물질을 형성하여 단일 전극을 가지는 구조를 가지고 있다. 히터와 감지전극으로 사용되는 Pt는 glass 기판위에 스퍼터링법으로 형성하였으며, SnO_2 감지물질은 제작된 Pt 전극위에 열증착시켜 형성하였다. SnO_2막은 lift-off 공정을 이용해서 패턴을 형성하고 1시간 동안 산소분위기에서 열산화하였다. 제작된 소자의 크기는 1.92x.1 mm^2 이다. CO 가스에 대한 감지특성을 조사한 결과 1,000 ppm에 대해 100 mV의 출력변화를 나타내었으며, 넓은 농도범위(0 ~ 10,000 ppm에서 선형적인 전압출력을 나타내었다. 또한 가스 반응 전과 반응 후의 전압출력을 비교해 볼 때, 1 % 이내의 편차를 나타내는 우수한 회복성을 나타내었다. Micro gas sensor with single electrode was proposed for improving stability and sensitivity, Generally, metal oxide gas sensors have two electrodes for heating and sensing. This fabricated new type sensor have only a single electrode by forming a sensing material onto heating electrode. Pt as a heating and sensing electrode was sputtered on glass and a SnO_2 sensing material was thermally evaporated on Pt electrode. SnO_2 was patterned by lift-off process and then thermally oxidized in O_2 condition for 1 hr., 600 ℃. The size fabricated sensor was 1.9 x 2.1 mm^2. As a result of CO gas sensing characteristics, this sensor showed 100 mV change for 1,000 ppm and linearlity for wide range(0 ~ 10,000 ppm) of gas concentrations. And the sensor shows a good recovery characteristics of 1 % deviation compared to initial resistance.
이덕동,최낙진,심창현,허증수,주병수,송갑득,정종경 경북대학교 전자기술연구소 2001 電子技術硏究誌 Vol.22 No.2
Two SnO₂ based sensing films(pure SnO₂ and SnO₂/Pt) and a Pt thin film for temperature sensor on an alumina substrate were designed and fabricated for classifying the indoor environmental gases. By controlling the heating power in the shape of trapezoid, we made one temperature profile of SnO₂ sensing films and the unique four sensing response curves to the tested gases from both SnO₂ and SnO₂/Pt film. We extracted variables from sensing response curves and carried out principal component analysis(PCA) with the variables and confirmed that the sensor array with this operating mode was very effective in classifying indoor environmental gases such as CO₂, C₃H_8, C₄H_(10).