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조형곤 대한흉부심장혈관외과학회 1986 Journal of Chest Surgery (J Chest Surg) Vol.19 No.1
Thirteen patients with cyanotic cardiac malformations having more complex intracardiac defects, hemodynamics and operative procedures than ones in Tetralogy of Fallot undertaken total surgical corrections from July 1981 to August 1985. The cases of corrective surgery for complex cardiac malformations were 3.9% of all congenital cardiac malformations and 12.6% of cyanotic cardiac malformations. Six patients died within 30 days after surgery. So operative mortality was 46%; Transposition of the great arteries, two of 4 patients, due to low cardiac output syndrome and tracheal bleeding ; Univentricular heart, one of 3 patients, due to bleeding; Corrected transposition of the great arteries, one of 2 patients, due to acute heart failure; Tricuspid atresia, one of 2 patients, due to low cardiac output syndrome; Double outlet right ventricle, one of single patient, due to respiratory failure. The cases of surgical correction for complex cardiac malformations are progressively increasing in numbers. The more accurate evaluation of anatomical condition and hemodynamics in preoperative diagnosis, studies on applicable surgical procedure and perioperative care of patients are necessary in the improvement of clinical and surgical results.
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펄스전류 가열에 의한 나노구조의 (Ti,Mo)C 합성과 동시 급속소결 및 기계적 성질
조형곤,권한중,손인진,Jo, Hyoung-Gon,Kwon, Hanjung,Shon, In-Jin 한국재료학회 2013 한국재료학회지 Vol.23 No.11
Nanocrystalline materials have recently received significant attention in the area of advanced materials engineering due to their improved physical and mechanical properties. A solid-solution nanocrystalline powder, (Ti,Mo)C, was prepared via high-energy milling of Ti-Mo alloys with graphite. Using XRD data, the synthesis process was investigated in terms of the phase evolution. Rapid sintering of nanostuctured (Ti,Mo)C hard materials was performed using a pulsed current activated sintering process (PCAS). This process allows quick densification to near theoretical density and inhibits grain growth. A dense, nanostructured (Ti,Mo)C hard material with a relative density of up to 96 % was produced by simultaneous application of 80 MPa and a pulsed current for 2 min. The average grain size of the (Ti,Mo)C was lower than 150 nm. The hardness and fracture toughness of the dense (Ti,Mo)C produced by PCAS were also evaluated. The fracture toughness of the (Ti,Mo)C was higher than that of TiC.
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조형곤 대한흉부심장혈관외과학회 1985 Journal of Chest Surgery (J Chest Surg) Vol.18 No.2
From Jun. 1980 to Mar. 1984, 33 cases of atrial septal defect, secundum type, operated at the department of Thoracic and Cardiovascular Surgery, School of Medicine, Keimyung University, were analyzed retrospectively. They were 24.3% of all congenital heart diseases operated in the same period. Among the 33 cases, 17 cases were males and 16 cases were females. Their ages were ranged from 4 to 42 years and cases of over 15 years of age were 60.6%. Main symptoms at admission were exertional dyspnea [69.7%], palpitation [63.6%] and frequent upper respiratory infections [51.5%], but 2 cases [6.1%] were asymptomatic. All 33 cases were operated under the direct vision with cardiopulmonary bypass. All cases were secundum type defect of atrial septal defect and single defect were in 29 cases [90.6%], and oval type defect were in 31 cases [96.9%]. In 7 cases [21.9%], other lesions of cardiovascular system were associated, and the most common lesion was pulmonic valvular stenosis [4 cases; 12.5%]. The defects were closed directly in 27 cases and in 6 cases with Dacron patch. Postoperative complications were occurred in 8 cases [24.2%], and they were pleural effusion, congestive heart failure, and alopecia mainly. One case died due to air embolism postoperatively and operative mortality was 3.1%.
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이식을 위한 가토심장의 장기 보존방법에 관한 비교 연구
조형곤,김수현,김송명,Jo, Hyeong-Gon,Kim, Su-Hyeon,Kim, Song-Myeong 대한흉부심장혈관외과학회 1997 Journal of Chest Surgery (J Chest Surg) Vol.30 No.1
심장이식 수술의 성공의 관건은 공여자와 수혜자의 적절한 조합과 이미 정립된 수술수기와 합께 적출된 심장의 효과적인 기능 보존에 달려있다. 심장 보존에 있어서 괄목할 만한 발전이 있었음에도 불구하고 최근의 가장 진보된 방법으로 심 허 혈 상태의 최대 허용기간은 약 4~6시간정도이다 저자는 이식을 위한 적출 심장의 보존 용액 이 갖추어야 할 적정 요건에 대한 자료를 축적하고자, 단순 저온 침적방법에 의거하여, H/S용액(I군)을 대조군으로 하여 저자가 고안한 CK용액(W군)을 기존의 MEC용액( ll군) 및 MUW용액(E군)과 비교 실험하였다. 적출된 가토의 심장을 실험 대상으로 하고 정압형 Langendorff실험모형을 사용하여, 20분간의 평형 상태, 4시간동안의 심장 저장 및 20분간의 재관류시기를 거치게 한 후, 심근 조직을 절제하여 냉동 보관하였다. 실험 계획에 따라 관관류량,좌심실압, 압력 미분치를 측정하였고, 동결 심근조직내의 효소치를 정량 분석하였다. 결론적으로, 저자의 비교 실험에서 MUW용액과 CK용액의 심근보호 능력이 우수하였고, MEC용액은 대조군에 비해 저조하였다. potassium의 농도가 MVW용액보다 낮고()4.2nM/L), 문헌상에서 \ulcorner\ulcorner보호에 유익한 것으로 보고된 각종의 substrate을 첨가하여 제작된 CK용액의 성적이 MUW용액 과 비슷한 수준으로 우수하였는데, 이는 심장보존용액의 전해질 농도의 조정과 첨가물질의 선택 및 조정에 있어서 지속적인 연구와 발전이 필요함을 시사한다고 할 수 있다. The successful cardiac transplantation depends partly on the donor heart preservation by a solution that will ensure recovery of myocardial function. The purpose of this study was to perform the evaluation of various preservation solutions and to accumulate the data on the requisites for ideal preservation solution. The experimental setup was the constant pressure Langendorffs perfusion system. Isolated rabbit hearts were perfused for 20minutes with unarm Krebs-Henseleit solution, stored for 4 hours in cold preservation solution after cardioplegia, and then were reperfused for 20minutes. The 4 experimental groups were prepared Hartmann's solution group (group 1, control), modified Euro-collins solution group(group II. MEC), modified University of Wisconsin group (group n, MUW), and CK solution(made by the author) group (group W, CK). The parameters for assessing the preservation ability were levels of enzymes in freezed myocardial tissues (lactate, creatine kinase-MB and adenosine deaminase), coronary flow. left ventricular developing pressure and dpldt. In conclusion, the ability of preservation for isolated rabbit heart was excellent in CK solution and modified University of Wisconsin solution, and poor in modified Euro-collins solution, compared with Hartmann solution. CK solution has low potassium concentrations(34.2mEq/L) and includes various substrates to be salutary on myocardial preservation. This fact may indicates the necessity of further refinements in selection or composition of electrolytes and substrates.
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조형곤,민경현,남태환,나승주,박재형,정세영 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.7
New basal insulin formulation was designed and their structural characteristics were investigated in vitro and biological activities in type 1 diabetic rats. Zinc-crystallized insulin was physically loaded into hydrophobically modified glycol chitosan (HGC) nanoparticles by a dialysis method. The series of insulin-HGC formulations were prepared with different feed weight ratio of insulin to HGC from 0.5:1 to 4:1. The loading contents of insulin and size distribution of insulin-HGCs were characterized, and blood glucose responses were investigated in streptozotocin-induced diabetic rats after single subcutaneous injection of regular insulin and insulin-HGCs. The highest loading efficiency and content were obtained in insulin-HGC when a 1:1 feed weight ratio of insulin to HGC was employed. The hydrodynamic diameter of insulin-HGC nanoparticles were in the range of 200 to 500 nm with narrow size distribution. Insulin-HGC effectively sustained insulin release up to 40% within 12 hours followed by a slower controlled release. Insulin-HGC showed an extended blood glucose lowering effect up to 24 h and provided normal blood glucose levels after oral glucose (1.5 g/kg) load at 24 hours post-injection while regular insulin showed severe hypoglycemia. The prolonged time action profiles and low variability of insulin-HGC formulation resulted in improved blood glucose control in diabetic rats and fulfilled a pattern desirable of a basal insulin.
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조형곤 대한흉부심장혈관외과학회 1986 Journal of Chest Surgery (J Chest Surg) Vol.19 No.4
From February 1986 through September 1986, the authors have experienced 6 cases of coronary artery bypass graft for patients with unstable angina. There were five males and one female who ranged from 39 to 65 years [mean, 53.3 years]. The extent of coronary disease was as follows: one-, two- and three-vessel diseases, all 2 cases respectively, and among them, 1 case had left main disease. Distal anastomoses were performed first with using saphenous vein grafts as conduits in all cases and sequential bypass methods were employed in 5 cases. Numbers of vein grafts were two in 2 cases and one in 4 cases. The mean time wasted for one distal anastomosis was 36 minutes. Post operative complications were leg-wound disruption [2 cases], transient psychosis [1 case] and perioperative myocardial infarction [MI] [1 case]. Sixty three year-old male patient associated with cardiomegaly, prior MI, ventricular arrhythmia, cardiac dysfunction and endocrinologic diseases preoperatively was expired in the operating room due to perioperative Ml. All survivors were asymptomatic and on discontinuing medical therapy on follow-up varying from 1 to 8 months.
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조형곤 대한흉부심장혈관외과학회 1986 Journal of Chest Surgery (J Chest Surg) Vol.19 No.3
Truncus Arteriosus is uncommon, accounting for 0.4%-2.8% of all congenital cardiac malformations. Truncus arteriosus has a poor prognosis in early infancy and defined as "a single arterial trunk that leaves the heart by way of a single arterial valve and that gives rise to the coronary, systemic and one or both pulmonary arteries directly." Through antemortem study of patients with truncus arteriosus the development of surgical techniques for palliation and correction was established. Recently we had surgical experience of truncus arteriosus - Collett '||'&'||' Edwards type 2. The main pulmonary artery was originated from truncus at right posterolateral aspect. Truncal valve was tricuspid with good coaptation. Ventricular septal defect was subarterial type of 2.0 cm in diameter. After detachment of the main pulmonary artery from truncus, truncus was repaired directly. Ventricular septal defect was closed with Dacron patch. Extracardiac valved conduit [Carpentier-Edwards: 16mm] was employed for making continuity between right ventricular outflow tract and pulmonary artery. Postoperatively, incomplete right bundle branch block on electrocardiogram was continued. Patient was died due to respiratory failure in postoperative 40 days.s.
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