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조항주(Hang Joo Cho),안창혁(Chang Hyeok Ahn),김지일(Ji Il Kim),김기환(Kee Hwan Kim),배자성(Ja Seong Bae),박우찬(Woo Chan Park),송병주(Byung Ju Song),정상설(Sang Seol Jung),김정수(Jeong Soo Kim) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.72 No.6
Purpose: The methylation of tumor suppressor genes has been implicated in the development of breast cancer. However, the role of methylation in the progression of cancer is still unclear. In this study, the methylation stati of nine tumor suppressor genes (p14, p16, DAPK, E-cadherin, RASSF1α, TWIST, RARβ, HIN-1, cyclin D2) in normal, benign, DCIS and invasive cancer tissues were examined, and the methylation patterns in DCIS and hypermethylated genes investigated to see if a change in the methylation status would lead to the development of cancer and progression to an invasive tumor. Methods: A total of 96 patients, who underwent surgery between March 2003 and March 2005, were retrospectively studied. DNA was extracted from tumor tissues, and the samples examined for aberrant hypermethylation using methylation-specific PCR (MSP). Results: The total number of methylated genes in each tissue type (normal tissues; 2.97±1.74, benign tumors; 4.36 ±1.42, DCIS; 5.73±1.35, invasive cancers; 5.42±2.05) increased with tumor progression (P<0.001). In benign tumors, HIN-1 (83%) was the most frequently methylated gene, but in DCIS, p14 (100%), RASSF (100%) and TWIST (91%) were frequently methylated. In invasive cancer, RAR β (60%) and p16 (37%) were frequently methylated compared to the other tissue types. In a multivariate study, TWIST was commonly hypermethylated in DCIS and invasive cancer; whereas, RARβ and p14 were frequently independently hypermethylated in invasive cancers. Conclusion: Methylation induced gene silencing appears to affect multiple genes in breast tissues, which increases with cancer progression. TWIST was hypermethylated in both DCIS and invasive cancers; therefore, it was concluded that methylation of the TWIST promoter may be an early event in the development of breast cancer. The hypermethylations of RARβ and p16 are useful marker for the progression of a DCIS lesion to invasive cancer. The methylation patterns of tumor suppressor genes in DCIS were similar to those found in invasive cancer, but also showed intermediate levels of methylation between benign tumors and invasive cancers.
조항주 ( Hang Joo Cho ),경연영 ( Yeon Young Kyoung ),오주석 ( Ju Suk Oh ),오영민 ( Young Min Oh ),최세민 ( Se Min Choe ),최경호 ( Kyoung Ho Choi ) 대한외상학회 2010 大韓外傷學會誌 Vol.23 No.2
Splenic rupture is a frequent surgical emergency in blunt abdominal trauma patients. There are several treatment options, including conservative treatment, a partial splenectomy, splenorrhaphy, and a splenectomy for splenic injury. Although reports on the safety and the efficacy of an elective laparoscopic splenectomy are abundant in the literature, a laparoscopic splenectomy for a ruptured spleen has only been reported in a few cases. We report a case of a laparoscopic splenectomy in the patient with Grade III traumatic splenic injury. To our knowledge, this is the first report in which a laparoscopic splenectomy was performed in Korea for the treatment of a traumatic splenic injury. (J Korean Soc Traumatol 2010;23:192-195)