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      • 全北 東部 地域 石槨墓 出土 土器 硏究 : 長頸臺와 器臺를 中心으로(Focused on Long necked Pottery and Pottery Stand)

        趙仁振 전북대학교 2001 국내석사

        RANK : 247631

        An earthenware which is excavated in a tomb serves as a mirror of the period. As an earthenware has unique aspects with that period or place. Therefore, it has a major subject out of many studies about tomb. Not only studies of a tomb in Gaya is in lively progress, but that of an earthenware in the province is being broken into parts. The studies of Vertical digging stone lined tomb in Gaya has been continued with Youngnam as a center. Compared with this, the studies about Stone lined tomb of Eastern-Chonbuk is still in an early stage of its studies. It is also problem that most researchers recognize this province as a outskirts of Gaya. Although studies of Stone lined tomb in Eastern-Honam is just begun, it has no real studies of an earthenware in Stone lined tomb. This research made an attempt a formal classification and a chronicle through Long necked pottery and Pottery stand which is excavated in Stone lined tomb of Eastern-Chonbuk. Moreover, this studied the progress and change of an earthenware in Stone lined tomb through the analytic results. Long necked pottery, as a analytic subject, is classified with Long necked pottery with cover and Wide mouth long necked pottery, and Pottery stand is divided with Mounted cup type pottery stand, Big pipe type pottery stand, Mid pipe type pottery stand and Ring type pottery stand. The analytic subject consists of 51 pieces of Long necked pottery with cover, 40 pieces of Wide mouth long necked pottery and 41 pieces of Pottery stand, exactly 132 pieces as a whole. These are reported through digging research, gathering research and surface gathering in Namwon, Jangsu, Jinan and Imsil, where is located in the most upper stream of 3arngang, Kumgang and Sumjingang respectively. Long necked pottery with cover has the most definite change in analytic subjects. As a result of shape in mouth, neck. and body, it totally comes in eight kinds, and shows a specific change with period. 'I iAa-style', what is something characteristic not found any other province, can he set up "Wolsanri-style". Being inflow of Goryung-style, Wolsanri-style showed two forms in Long necked pottery. The two were gradually alternated with a typical Goryung-style, which changed into Degeneration-style at the end of Gaya. That is, it changed like 「Wolsanri-style → Wolsanri and Goryung-style → Goryung-style → Degencration-style」 Wide mouth long necked pottery, what is found not only in Gaya, but in Beakje, has difficulty of classification in size because of external feature. Compared with other provinces, it has varieties of kind that is excavated in Vertical digging stone lined tomb of Eastern-Chonbuk. As a result of analytic possibility, it can be arranged into six forms. In these, we can find both Wolsanri-style and Beakje-style. Wide mouth long necked pottery, differently with Long necked pottery with cover, has so many forms that we easily find the variation of each style. Pottery stand consists of Mounted cup type, Big pipe type, Mid pipe type and Ring type. Mounted cup type, Big pipe type, and Ring type are limited to Namgang-system. Mid pipe type is equally excavated everywhere except Sumjingang-system. Mounted cup type pottery stand shows the most regional characteristics in these. It can be set up "Wolsnri-style" so as that IB-style is only shown in Wolsanri. Being excavated of Sogaya in Pottery stand as well, we can estimate intercourse or relation with Sogaya. As above mentioned analysis, we can divide into four steps in this province. The first step, Wolsanri-style, is situated in the 2/4 of fifth century. The second, mingling Wolsanri-style and early Goryung-style, is in the 3/4 of fifth century. The third, typical Goryung-style, is from 4/4 of fifth century to l/4 of sixth century. The fourth, degenerating Goryung-style, is after the l/4 of sixth century.

      • 체육교육전공 교육대학원생들이 임용고사 준비 과정에서 경험하는 어려움 탐색

        조인진 경북대학교 교육대학원 2019 국내석사

        RANK : 247631

        본 연구의 목적은 체육교육전공 교육대학원생들이 임용고사를 준비하는 과정에서 경험하는 어려움을 탐색하고자 하며, 이를 통해 체육교육전공 교육대학원생의 삶을 이해하고 진로의 제약 문제들의 대안을 마련하기 위한 기초 자료를 제공하고자 한다. 연구목적을 달성하기 위해 교육대학원 졸업생 중 임용고사를 준비 중인 준비생 2명, 임용고사를 합격한 교사 2명을 연구 참여자로 선정하였다. 자료는 심층면담을 통해 수집하였으며, 수집 된 자료는 귀납적 범주분석을 통해 요인들을 추출하였다. 연구결과 체육교육전공 교육대학원생들이 임용고사 준비 과정에서 경험하는 어려움은 ‘실기수업 부재’, ‘교육과정 혼재’, ‘심리적 불안감’으로 범주화 되었다. 교육대학원의 교육과정에 실기수업이 부족하여 2차 실기시험을 준비하는데 어려움을 경험하는 것으로 나타났으며, 교사재교육과 교사양성교육의 교육과정 혼재로 인해 교사재교육에 관련된 수업을 듣고 있는 것으로 나타났으며, 이로 인해 인터넷 강의와 사설학원을 통해서 임용고사에 관련된 내용을 보충하고 있었다. 또한 인터넷 강의와 사설학원 등록비와 학부생에 비해 상대적으로 많은 나이로 인해 심리적인 불안감을 격고 있었으며, 이로 인해 임용고사를 준비하는데 어려움을 경험하는 것으로 나타났다. 이러한 연구 참여자들의 어려움은 교육대학원생 개인적인 수준에서 해결하기에는 한계가 있는 것으로 나타났다. 마지막으로 연구결과를 바탕으로 체육교육전공 교육대학원생이 임용고사를 준비하는데 경험하는 어려움의 해결하기 위한 방안으로 교육대학원 체육교육전공의 교육과정에 실기교육과정 추가와 교사양성과정과 교사재교육의 분리하여 운영 할 것을 제언하였다. The purpose of this study is to explore the difficulties experienced by graduate students who major in physical education in graduate school of education in the process to prepare for the teacher recruitment examination and to provide basic data for understanding life of graduate students who major in physical education in graduate school of education and preparing alternatives career constraint issues through this. In order to accomplish the purpose of the study, 2 students who are preparing for the teacher recruitment examination and 2 teachers who passed the teacher recruitment examination of the graduates of graduate school of education were selected as participants in the study. The data were collected through in-depth interviews and factors were extracted from the collected data through an inductive analysis of categories. In the results of the study, the difficulties experienced by graduate students who major in physical education in graduate school of education in the process to prepare for the teacher recruitment examination were categorized as 'absence of practice classes', ‘the mixture of curriculums’, and‘psychological anxiety.’Lack of practice classes in curriculums of graduate school of education has found that the subjects experience difficulties in preparing for the second practical examination. The mixture of teachers' reeducation and education curriculums has found that the participants in the study take classes related to teachers' reeducation and supplement contents related to the teacher recruitment examination through lectures on the internet and private institutes due to this. And the participants in the study suffer psychological anxiety due to tuition fees of lectures on the internet and private institutes and their older age than undergraduates and have found to experience difficulties in preparing for the teacher recruitment examination due to this. These difficulties of the participants in the study have found to have limits to be solved on an individual level of graduate students of graduate school of education. Finally, the study suggested the addition of practice classes to curriculums for majoring in physical education in graduate school of education and separation and operation of teachers' education from their reeducation as plans to solve difficulties experienced by graduate students who major in physical education in graduate school of education while preparing for the teacher recruitment examination based on the results of the study.

      • 갑상선분화암 추적관찰에 있어 갑상선호르몬 중단에 따른 대사적 변화 및 호르몬 중단 필요성에 대한 고찰

        조인진 전북대학교 일반대학원 2013 국내석사

        RANK : 247631

        Introduction: After total thyroidectomy, differentiated thyroid cancer (DTC) patients have to undergo levothyroxine (LT4) withdrawal for measurement of TSH stimulated thyroglobulin (Tg) and 131I whole-body scan to evaluate residual or recurrent disease. It is well known that hypothyroidism can affect various target organs and tissues. But, there are a few studies looking into the effects of LT4 withdrawal in DTC patients in terms of metabolic parameters. Furthermore, sensitivity of other imaging modalities for detection of recurred DTC were markedly improved and false negative rate of TSH stimulated Tg was also reported. Therefore, present study was aim to investigate the metabolic changes by short-term hypothyroidism induced by LT4 withdrawal and to discuss the necessity of LT4 withdrawal. Methods: The patients were included who underwent high dose radioactive iodine (RAI) therapy due to recurred or remnant DTC after total thyroidectomy and post-operative RAI therapy, from January 2000 to October 2012 at Chonbuk national university hospital. Total 84 patients were reviewed by medical record and laboratory data, retrospectively. Body weight, body mass index (BMI), serum sodium, liver function test (AST, ALT), lipid profiles (total cholesterol, triglyceride, LDL cholesterol), serum creatinine, protein, albumin, and glucose levels were determined both before and after LT4 withdrawal. And false negative rate of TSH stimulated Tg and effect of anti-Tg antibody on measurement of Tg were evaluated. Results: There was no significant change in body weight, BMI, sodium, protein, albumin and glucose after LT4 withdrawal. But there were statistically significant increases in AST, ALT, total cholesterol, triglyceride, LDL cholesterol and serum creatinine after LT4 withdrawal (p<0.001). 29 of 84 patients showed TSH stimulated Tg level below 2ng/ml after LT4 withdrawal despite of remnant or recurred disease detected in imaging modalities (false negative rate : 34.52%). Only 2 patients were detect recurred or remnant DTC by TSH stimulated Tg. Positivity of anti-Tg antibody was 35.71% (30 of 84 patients). Among them, the patients who showed serum Tg level below 2ng/ml was 63.33% (19 of 30 patients). Conclusions: Short-term hypothyroidism induced by LT4 withdrawal in DTC patients seriously affects multiple organs and systems. In this study, short-term hypothyroidism was associated with significant increases in risk factors for atherosclerosis, renal and hepatic dysfunctions. Furthermore, TSH stimulated Tg showed relatively low sensitivity compared to other imaging modalities. Therefore, alternative methods including specific imaging modalities or use of recombinant human TSH instead of LT4 withdrawal should be considered, especially patients with high risk of iatrogenic hypothyroidism.

      • (The) effect of allopurinol on the high fructose diet-induced hepatic steatosis in OLETF rats

        조인진 경희대학교 대학원 2016 국내박사

        RANK : 247631

        Background: Excess fructose consumption contributes to the development of obesity, metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD). Uric acid, a metabolite of fructose metabolism, may have a direct role in the development of NAFLD, but the mechanism is unclear. Therefore, to evaluate the contributions of fructose and uric acid on NAFLD development, the effects of uric acid lowering treatment on fatty liver was examined using a high fructose diet-induced fatty liver rat model. Methods: Thirty-week-old OLETF male rats were divided into three groups: (1) normal chow-diet OLETF rats (NC group, n=10); (2) high fructose-diet OLETF rats (HFrD group, n=10); and (3) high fructose-diet OLETF rats with allopurinol treatment (HFrDAL group, n=10). After 16 weeks of treatment, an intraperitoneal glucose tolerance test (IPGTT) was performed to measure glucose metabolism parameters. After sacrifice, liver tissue was processed to assess histological characteristics and real-time polymerase chain reaction (PCR) was performed to evaluate expression of genes involved in lipid metabolism and inflammation. Endoplasmic reticulum (ER) stress pathway modulation was evaluated by Western blot. Results: The HFrD group had significantly elevated body weight, as well as higher serum uric acid and triglyceride concentrations compared to the NC group (P<0.05). In the IPGTT, blood glucose concentrations at 2 hours were significantly increased in the HFrD and HFrDAL groups compared with the NC group (P<0.05). The mean NAFLD activity score was significantly increased in the HFrD group versus the NC group (P<0.05). Allopurinol treatment significantly reduced body weight, decreased serum uric acid concentrations, and ameliorated hepatic lipid accumulation in the HFrDAL group compared with the HFrD group (P<0.05). High fructose diet significantly suppressed hepatic expression of fat oxidation genes in the HFrD group, which was ameliorated by allopurinol treatment in the HFrDAL group. Hepatic expression of pro-inflammatory cytokine genes was significantly elevated in the HFrD group, but not in the HFrDAL group (P<0.05). Furthermore, high fructose diet-induced hepatic ER stress pathway activation was inhibited by allopurinol treatment. Conclusions: Allopurinol ameliorates high fructose diet-induced hepatic steatosis through modulation of hepatic lipid metabolism and pro-inflammatory cytokines expression. Allopurinol also partially affects ER stress pathway induction. Therefore, uric acid may have a direct role in the development of fructose-induced hepatic steatosis, and uric acid lowering therapy could be a candidate for the prevention or treatment of NAFLD. 배경: 과도한 과당섭취는 비만, 대사증후군, 그리고 비알코올성 지방간을 발생시킨다. 과당은 주로 간에서 대사가 되며, 대사과정에서 세포 내 요산 합성이 증가된다. 요산이 비알코올성 지방간 발생에 직접적인 영향을 미칠것으로 생각되지만, 정확한 기전에 대해서는 아직은 확실하게 밝혀지지 않은 상태이다. 본 연구에서는 과당과 이의 대사산물인 요산이 비알코올성 지방간 발생에 관여하는 기전을 알아보고자 고과당식이로 유도한 지방간 동물모델을 이용하여 요산 생성 억제제가 지방간에 미치는 효과를 알아보고자 하였다. 방법: 30주령 OLETF 쥐를 사용하여 1) 정상식이군 (normal chow-diet OLETF rats group, 이하 NC군), 2) 고과당식이군 (high fructose-diet OLETF rats group, 이하 HFrD군), 3) 고과당식이 + 알로퓨리놀 투여군 (high fructose-diet OLETF rats with allopurinol treatment group, 이하 HFrDAL군) 으로 나누어 16주간 연구를 진행하였다. 연구 종료 후 복강 내 당부하검사를 시행하여 당 대사의 차이를 확인하였고, 공복 혈액 샘플을 통해 생화학검사를 진행하였다. OLETF 쥐를 마취 후 간을 적출하여 간 조직의 지방간 정도를 NAFLD activity score (NAS) 을 이용하여 평가하고, 간 조직에서 지방 대사에 관여하는 효소와 염증 관련 사이토카인의 유전자 발현 및 소포체 스트레스 경로에 대해 알아보고자 polymerase chain reaction 과 western blot 을 진행하였다. 결과: NC군과 비교 하였을 때 HFrD군에서 유의한 체중 증가와 혈중 요산 및 중성지방의 증가를 보였다. 복강 내 당부하검사 결과, NC군에 비해 HFrD군과 HFrDAL군에서 2시간 후 혈당이 유의하게 증가하였다. 간 조직검사로 평가한 NAS는 HFrD군에서 NC 군에 비해 유의하게 증가하였다. 반면 알로퓨리놀을 투여한 HFrDAL군에서는 HFrD군에 비해 유의한 체중 감소와 혈중 요산의 감소를 보였으며, 고과당식이에 의해 발생한 지방간의 유의한 호전을 보였다. HFrD군에서는 고과당식이에 의해 간 내 지방산화에 관여하는 유전자 (PPARα, CPT-1)의 발현이 유의하게 감소하였고, 이는 HFrDAL군에서 알로퓨리놀 투여에 의해 회복되는 결과를 보였다. 간 내 염증 관련 사이토카인 (TNF-α, PAI-1)의 유전자 발현은 HFrD군에서 유의하게 증가하고, HFrDAL군에서 유의하게 감소하였다. 또한, 고과당식이에 의해 활성화 된 소포체 스트레스 경로 (IRE1 경로)가 알로퓨리놀 투여에 의해 억제되었다. 결론: 알로퓨리놀은 간 내 지방 대사에 관여하는 효소와 염증 관련 사이토카인의 유전자 발현을 조절함으로써 고과당식이에 의해 유도된 지방간을 호전시켰다. 또한, 알로퓨리놀은 소포체 스트레스 경로에도 부분적으로 영향을 미쳤다. 따라서 고과당식이에 의해 증가된 요산이 비알코올성 지방간 형성에 중요한 요인으로 작용하는 것을 알수 있었고, 이는 세포 내 요산 생성을 억제하는 약제인 알로퓨리놀이 비알코올성 지방간 치료 및 예방에 새로운 치료제로 이용될 수 있음을 시사한다.

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