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조민석,박해웅,이길현,윤혜경,오경모,최석철,현경예 대한의생명과학회 2019 Biomedical Science Letters Vol.25 No.1
This study was undertaken to investigate the therapeutic effect of Angelica acutiloba on allergic dermatitis, which Angelica acutiloba is traditionally known to have antiinflammatory effects. Sprague-Dawley (SD) rats were divided into five groups: normal control group, experimental allergic dermatitis group (vehicle group), low dose of Angelica acutiloba extract (low-dose group), high dose of Angelica acutiloba extract (high-dose group), and antihistamine treated group with experimental dermatitis (antihistamine group). Total leukocyte, neutrophil, lymphocyte, monocyte and eosinophil counts were significantly higher in the vehicle group than in the control group, but these variables were significantly lower in the low- and high-dose groups than in the vehicle group. The platelet/lymphocyte ratio in the red blood cell index was significantly lower in the low- and high-dose groups than in the vehicle group. Low and high doses of the Angelica acutiloba extract did not have toxic effects on liver and kidney. Serum NO, iNOS and levels were highest in the vehicle group but significantly lower in the low- and high-dose groups, especially in the high-dose group. The results of this study suggested that the Angelica acutiloba extract had the effect of alleviating or treating the experimental allergic dermatitis, and it was concluded that the high dose was more effective.
틱 장애 환자에서 Aripiprazole 투여 후 발생한급성 근이긴장증(Acute Dystonia) 사례
조민석,심세훈 대한정신약물학회 2008 대한정신약물학회지 Vol.19 No.2
An 8-year-old female with Tourette Disorder (TD) was treated with a daily oral dosage of 5 mg of aripiprazole, which did not significantly improve her symptoms. After treatment with 10 mg daily for 3 days, she experienced an acute episode of dystonia with facial muscle spasms, opisthotonus, and torticolis. All symptoms resolved after ingestion of a totalof 2 mg of benztropine over 2 days. Previously, aripiprazole was considered to cause few anticholinrgic, antiadrenaline, or antihistamine effects or extrapyramidal symptoms. However, extrapyramidal symptoms have now been reported in patients with TD and in adolescent patients with other psychiatric disorders. We reviewed the literature, and to the best of our knowledge, this is the first report of a child TD patient with acute dystonia. Although the recommended treatment largely precludes acute dystonic reaction, aripiprazole has produced this reaction. 뚜렛장애를 가진 8세된 여아가 2주간 매일 aripiprazole 5 mg을 투여 받았으나 뚜렷한 호전을 보이지 않았다. 이에 일일 10 mg으로 증량하여 3일간 투여하자, 안면 근육 경련, 사경, 후궁반장 등의 급성 근육긴이긴장증이 발생하였다. 이 모든 증상은 2일간 benzropine 1 mg을 매일 투여하자 호전되었다. aripiprazole은 뚜렛장애 환자들에 있어서 항 콜린, 항 아드레날린, 항 히스타민 작용이 적고 추체 외로계 부작용이 발견되지 않는다고 알려져 왔었다. 그러나 최근 청소년 혹은 뚜렛장애 환자에서 추체 외로계 부작용이 보고되고 있는 바, 이번 증례는 뚜렛장애를 동반한 소아 환자에서 aripiprazole로 인한 급성 근이긴장증이 발생한 첫 사례라고 생각되어 보고하는 바이며, 관련 문헌을 함께 고찰하였다. aripipra-zole은 제안된 약물 기전 상 가능성이 적다고 알려졌으나, 뚜렛장애 환자에서 급성 근이긴장증을 발생시킬 수 있다고 보여진다.