Ixodes nipponesis에 의한 참진드기 교상 2예 - 주사전자 현미경적 관찰 -

조남준,방동식,조백기,오영진,이원구 ( Nam Joon Cho,Dong Sik Bang,Baik Kee Cho,Young Jin Oh,Won Koo Lee ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.4

Two Cases of Tick Bites Caused by Ixodes Nipponensis -Scanning electron microscopic study- Nam Joon Cho,M.D.,Dong Sik Ban, M.D., Bailk Kee Cho, M.D*., Young Jin Oh,M.D.,* Won Koo Lee, Ph.D.** Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea Department of Dermatology, Catholic University Medical College*, Seoul, Korea Department of Biology, College of Science, Chonbuk National University**, Chonju, Korea We report two cases of tick bites caused by Ixodes nipponensis. One patient was a 10-month-old female who developed a protruding mass and tiny bleeding on forehead for about one week. The other was a 5-year-old female who had had a tick on occipital area for an unknown period. A excision biopsy specimen from the skin lesion of the latter case showed mild inflammatory cells in the dermis and dense inflammatory cells mainly composed of neutrophils in the subcutaneous fat. The two ticks were identificated as Ixodes nipponensis by scanning electron microscopic study. (Kor J Dermatol 29(4) : 533-537, 1991)

발진성 , 결절성 , 수장선상 황색종을 동반한 제 III형 과지질단백혈증

조남준,유욱,김정호,이승헌 ( Nam Joon Cho,Wook Lew,Jeong Ho Kim,Seung Hun Lee ) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.2

We report a case of type Ⅲ hyperlipoproteinemia associated with xanthoma eruptivum. xanthoma tuberosum, and xanthoma striatum palmare whose clinical symptoms have been improved by the treatment of gemfibrozil. A 31-year-old male patient visited our clinic for evaluation of multiple yellowish nodules on the elbows, multiple yellowish papules on the buttocks and linear yellowish palques along with the palmar creases on both palms. The blood chemistry showed an elevation of cholesterol and triglyceride. Lipoprotein electrophoresis showed broad β zone and plasma standing test showed turbid plasma. Lipoprotein ultracentrifugation showed that the ratio of VLDL cholesterol and plasma triglyceride was 0.38. According to the above findings, we diagnosed this patient as type Ⅲ hyperlipoproteinemia. Afer 4 months of treatment with diet and gemfibrozil, the serum level of cholesterol and triglyceride were reduced to normal range. The skin lesions of both palms showed marked improvement but the skin lesions on elbows and buttocks were not much improved. .(Korean J Dermatol 1994;32(2):321-326)

소결체와 저탄소강의 레이저용접시 생성되는 캐비티의 형성과 용접 특성에 대한 연구

조남준,정우광,김성욱,이창희,김승대,Cho Nam-Joon,Jung Woo-Gwang,Kim Sung-Wook,Lee Chang-Hee,Kim Sung-Dea 한국재료학회 2004 한국재료학회지 Vol.14 No.4

A laser welding has been made between sintered tip of Fe-Co-W and low carbon steel shank for the diamond saw blade. The welding characteristics and formation of defect has been investigated carefully for the weld fusion zone in different welding condition. Full penetration has been observed for the whole range of heat input investigated in the present work. Bead width and under-fill have been increased with the increase of heat input. With increasing of heat input small cavities were decreased while large cavities were increased. The ratio of total cavity area to the entire weld bead area was not changed significantly with change of heat input. Most of cavities were found near the tip, and supposed to be formed from the pore in the tip.

알레르기성 접촉피부염과 원발성 접촉피부염에서 랑게르한스세포 , la 양성 각질형성세포와 Thy - 1 양성 수지상표피세포의 변화

조남준,김수찬,방동식,박윤기 ( Nam Joon Cho,Soo Chan Kim,Dong Sik Bang,Yoon Kee Park ) 대한피부과학회 1993 大韓皮膚科學會誌 Vol.31 No.3

충남 (忠南) 및 강원지역 (江原地域) 목장용수의 (牧場用水) 위생세균의 춘하절 변화

조남준,박석기 ( Nam Joon Cho,Seog Gee Park ) 한국하천호수학회 1993 생태와 환경 Vol.26 No.4

In order to investigate the microbiological conditions of farm waters, we examined the heterotrophic plate count, coliforms, fecal E. coli, psychrophilic bacteria, heat-resistant bacteria, Pseudomonas aeruginosa, enterococcus and staphylococcus in 58 farms of Chungcheongnam and Kangwon Province. The results were as follows: Out of 58 farm waters(Chungnam 29 samples and Kangwon 29 samples), the average number of psychrophilic bacteria in spring was 10^(1.407)±10^(0.196)CFU/ml, heterotrophic plate count(HPC) 10^(1.349)±10^(0.160)CFU/ml, p. aeruginosa 10^(0.339)±10^(0.109)CFU/100ml, coliform 10^(0.350)±10^(0.095)CFU/ml, fecal F. coli 10^(0.081)±10^(0.046)0F7/100ml, heat-resistant bacteria 10^(0.885)±10^(0.086)CFU/ml, enterococcus 10^(0.022)±10^(0.022)CFU/100ml and staphylococcus 10^(0.163)±10^(0.069)CFU/ml respectively, but the average number of psychrophilic bacteria in summer was 10^(1.782)±10^(0.159)CFU/ml, heterotrophic plate count 10^(2.132)±10^(0.142)CFU/ml, Pseudomonas aeruginosa 10^(0.764)±10^(0.158)CFU/100ml, coliform 10^(0.966)±10^(0.126)CFU/ml, fecal E. coli 10^(0.602)±10^(0.138)CFU/100ml, heat-resistant bacteria 10^(0.973)±10^(0.108)CFU/ml, enterococcus 10^(0.347)r±10^(0.084)CFU/100ml and staphylococcus 10^(0.667)±10^(0.116)CFU/ml respectively. There were the high significantly seasonal differences in heterotrophic plate count, coliform, fecal E. coli, enterococcus, P. aeruginosa and staphylococcus but not psychrophilic bacteria and heat-resistant bacteria. Especially in the farm waters of Kangwon Province, there were the significant seasonal difference in enterococcus, coliform and staphylococcus, but not in heterotrophic plate count, psychrophilic bacteria, fecal E. coli, heat-resistant bacteria and P. aeruginosa.

Skin Surface Hydrometer를 이용한 원발성 다한증 환자의 치료효과 판정

조남준,이융재,유욱,김동건,이승헌 ( Nam Joon Cho,Yung Jae Lee,Yook Lew,Dong Kun Kim,Seung Hun Lee ) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.3

다한증은 과다한 발한이 나타나는 질환으로, 현훈과 동반된 저혈압, 저혈당, pheochromocytoma, 온, 감정적 스트레스, 그리고 갑상선 기능항진증과 연관되어 나타나는 이차적인 다한증은 대개 전신적으로 땀분비가 증가하지만, 원발성 다한증은 대부분의 경우 손바닥과 발바닥에 국한되어 땀분비가 증가하거나, 겨드랑이에서 증가되는 경우도 있으며, 열에 의한 자극보다는 정신적 자극에 의해서 발한이 일어나는 것으로 알려져 있다. 원발성 다한증의 원인은 아직 확실히 알지는 못하나 현재까지는 교감신경계의 과민반응으로 인한 것으로 생각하고 있으며, 치료 방법으로는 aluminum chloride 용액을 위시한 국소도포제, 이온영동법, 교감신경 절제술 등이 있다. 땀분비량을 측정하는 방법으로는 bag이나 pack을 이요하여 땀을 수집하여 양을 측정, 전해질검사를 이용한 수분소실 정도의 측정, 한관이나 한선내로 미세관을 삽입하는 방법, 미세현미경을 이용한 사진분석, starch iodine, bromophenol blue, quinizarin 등의 지시약을 이용하여 수분과 접촉하여 색의 변화를 일으켜 여과지 혹은 silicone 등으로 인쇄하여 땀방울의 분포, 크기, 양, 형태 등을 측정하는 압입법 등이 사용되고 있다. 그러나 이러한 방법들은 조작이 복잡하고 시간이 많이 걸릴뿐만 아니라 반복실험을 통하여 동일한 결과를 기대하기 어렵다. 1982년 Tagami 등이 개발한 Skin Surface Hydrometer(SSH)는 종전의 방법과 달리 전기저항을 이용하여 각질층의 수분 함량을 측정할 수 있는 기계로 땀의 양을 측정하는 객관적 지표로 비교적 적합한 것으로 알려져 있다. 저자들은 수장족 저 다한증환자에서 치료전과 치료중 그리고 치료중단 후 SSH를 사용하여 땀분비량을 측정하여 SSH가 치료방법에 따른 치료효과판정과 수장족저다한증의 진단에 객관적인 지표로 사용될 수 있는지 알아보고자 본 실험을 시행하였다. Background:Primary hyperhidrosis is the disease of production of exessive sweat which is mainly localized in palm, sole, and axilla. Treatment of the disease is usually accomplished with topical 20% aluminum chloride solution, an iontophoretic device, and surgery(sympathectomy) being reserved for recalcitrant cases. Objective:We have compared the therapeutic effects with each treatments for hyperhidrosis using a skin surface hydrometer. Methods:Thirty six patients(11;male, 25;female) with primary hyperhidrosis were evaluated in this study. Nineteen patients used topical 20% aluminum chloride solution, 10 patients used iontophoretic device, and 7 patients in recalcitrant cases had sympathectomy. We have measured the conductance on the stratum corneum of the palm and sole using a skin surface hydrometer before and after treatment every weeks for a month. the control group were composed of healthy 10 males and 2 females. Results: 1. In the patients of primary hyperhidroisis the conductances of palm, sole and axilla were higher than that of control group(P<0.01). 2. There was a marked reduction of conductance after the treatment for one week by topical 20% aluminum chloride solution, an iontophoretic device, and sympathectomy(P<0.01). 3. After 2-4 week of treatment by topical 20% aluminum chloride solution, the conductance was nearly unchanged in comparison with the change obsetved after treatment for one week. 4. By iontophoretic device, there was a slight increasement of conductance of the palm after 2-3 weeks of treatment. 5. We obseved a sustained decrease in the conductance by sympathectomy into 4 week. Conclusion:Topical 20% aluminum chloride solution, iontophoretic device, and sympathectomy were effective for treatment of hyperhirosis. Among them sympathectomy saowed the best effect. We observed that the skin surface hydrometer is useful to evaluate of the efficacy of the treatment.(Korean J Dermatol 1994;32(3):369~375)

Leiner씨 병

조남준(Nam Joon Cho),최은선(Un Sun Choi),김동건(Dong Kun Kim) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.4

In 1908 Leiner described the peculiar skin condition among infants to which he applied the name erythroderma desquamativa. The four cardinal features of Leiners disease are generalized seborrheic dermatitis, intractable severe diarrhea, recurrent local and systemic infections usually of gram negative etiology, and marked wasting and cyst rophy. A 2-month-old female presented to our clinic with generalized seborrheic erythrodermic eruption and intractable diarrhea. She had sufferd from these symptoms since birth. Her body weight was 3.4kg (below 3rd percentile). Her scalp was covered with thick yellowish crsts. There was generalized erythroderma covered vith scales and crusts. Laboratory result; revealed gram negative sepsis and DIC. Chest X-ray showed the findings of minimal aspir ition pneumonia in the right upper lobe. She expired on the following day. (Kor J Dermatol 1992;30(4):543-545)

Petrolatum과 Tegaderm 처치가 피부장벽 손상 후 회복과 칼슘 기울기에 미치는 영향

조남준 ( Nam Joon Cho ),이은희 ( Eun Hi Lee ),강소군 ( Shao Jun Jiang ),최응호 ( Eung Ho Choi ),안성구 ( Sung Ku Ahn ),이승헌 ( Seung Hun Lee ) 한국피부장벽학회 2001 한국피부장벽학회지 Vol.3 No.1

형개연교탕(荊芥連翹湯) 가감방(加減方)의 발포정 제형 변화에 따른 약리학적 안정성 연구

조남준 ( Nam Joon Cho ),강성구 ( Seong Gu Gang ),김지영 ( Ji Young Kim ),한효상 ( Hyo Sang Han ),김기광 ( Kee Kwang Kim ) 대한본초학회 2018 大韓本草學會誌 Vol.33 No.5

Objectives : Natural extracts have been extensively studied to replace single agent drugs that cause a variety of side effects. However, studies of changes to the formulation of natural extracts has not been nearly proceed. We aimed to investigate whether pharmacological stability of hyeonggaeyeongyotang gagambang (HYT) is altered by formulation changes for foaming tablet. Methods : In this study, we performed freeze - drying of HYT, which is known to have antioxidant and anti - inflammatory properties, and then changed the formulation by foaming. Results : As a result, the foaming reaction appeared normally when HYT foamed tablets were put into water, and almost all of the substances were dissolved in the aqueous solution. In addition, we confirmed using high-performance liquid chromatograph that the geniposide used as an indicator material of HYT was stable in most of the formulations. It was confirmed that the change of HYT formulation did not affect the antioxidant efficacy by the 2,2'-azino-bis- 3-ethylbenzothiazoline-6-sulphonic acid assay. Moreover, quantitative real-time PCR confirmed that the inhibitory effect of HYT on IL-1β mRNA expression induced by lipopolysaccharides treatment in murine macrophage RAW 264.7 cells was similar in the solution of foaming tablet. Conclusions : These results suggest that the materials with various pharmacological effects can be stably maintained even when the formulation is changed by the foaming action of HYT. Our results are expected to provide important basic knowledge on formulation changes using various natural extracts.

백마고지 전투 간 국군 제9사단의 화력운용 고찰 - 포병운용을 중심으로 -

조남준(Cho, Nam-joon) 국방부 군사편찬연구소 2020 군사 Vol.- No.117

The study attempts to research the Fire employment of the Battle of White Horse Hill, in which the 9th ROK Infantry Division won against the 38th Corps of the Chinese People"s Volunteer Army in October 1952. Although many studies have been conducted officially and academically on the battle, however most of them are the study of analyzing the battle centered on maneuvers, whereas the role of firepower had been accepted less interests, in some cases, to extent of the just amount of ammunition that used during the battle. Even the numbers of artillery units participating are different based on studies. In this regard, this study analyzes the strength of firepower mobilized, operational plans, command and control systems, and actual performance of those units, based on primary historical records, like combat situation reports(sitreps) from the 9th ID, special reports from the Ⅸ U.S. Army Corps, reports from the U.S. Military Advisory Group, and testimonies from veterans. According to the study, the 9th ID put more firepower assets into the battle than previously known. even though the 9th ID operated the division-level fire support control center for the first time in the ROK Army, it smoothly commanded and controlled huge amount of firepower assets through flexible measures and pre-preparation. Although there were also negative incidents such as misfires during the battle, they carried out the battle in a variety of ways in the joint operation with the U.S. military. The effectiveness and efficiency of these fire employment was well illustrated by the 9th ID"s success to dispel incoming Chinese troops through the front lines by rapid fire employment. In conclusion, by using firepower effectively and efficiently, the 9th ID was able to win the Chinese troops three times more than themselves.