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한국인 정신분열병 환자에서 Apolipoprotein E 유전자의 다형성
조광현,정상근,황익근,Cho, Gwang-Hyun,Chung, Sang-Geun,Hwang, Ik-Keun 대한생물정신의학회 2003 생물정신의학 Vol.10 No.2
Objectives:Although polymorphisms of apolipoprotein E have been investigated in many neuropsychiatric disorders, results were controversial and even contradictory. The purpose of this study was to investigate the genotypes of apolipoprotein E in schizophrenia and healthy controls, and to compare them in two groups in terms of distribution of apolipoprotein E genotype and allele. Method:Using polymerase chain reaction and amplified refractory mutation system, apolipoprotein E genotypes were identified in 77 schizophrenics and 115 healthy control persons. Results:The results were as follows 1) When genotypes of apolipoprotein E were classified into ${\varepsilon}2/2$, ${\varepsilon}2/3$, ${\varepsilon}2/4$, ${\varepsilon}3/3$, ${\varepsilon}3/4$, ${\varepsilon}4/4$ according to phenotypes, there were no statistical differences in genotypes between two groups 2) In terms of allele frequency, there were also no statistical differences between two groups Conclusion:These results suggest that genotypes and alleles of apolipoprotein E seem to be unrelated to the pathogenesis of schizophrenia.
한국인 양극성 정동장애 환자에서 Apolipopretein E 유전자의 다형성
최재호 ( Jae Ho Choi ),조광현 ( Gwang Hyun Cho ),정상근 ( Shang Keun Ghung ) 전북대학교 의과학연구소 2003 全北醫大論文集 Vol.27 No.2
Objectives: Although genotype of apolipoprotein E has been investigated in many neuropsychiatric disorders, results were controversial and even contradictory. The purpose of this study was to investigate the nature of apolipoprotein E in bipolar disorder, and compare it with healthy control group in terms of distribution of apolipoprotein E genotype and allele. Methods: Using polymerase chain reaction and amplified refractory mutation system, apolipoprotein E genotype were identified in 115 bipolar disorder patients and 115 healthy control persons. Results: The results were as follows: 1) When genotype of apolipoprotein E were classified as E2/2, E2/3, E2/4, E3/3, E3/4, E4/4, according to phenotypes, there were no statistical differences in genotyprs between two groups. 2) In terms of allele frequency, there were also no statistical differences between two groups. Conclusion: These results suggest that genotypes and alleles of apolipoprotein E seem to unrelatrd to pathogenesis of bipolar disorder.