가토 문맥에 있어서 비 코린성, 비 아드레나린성 억제성 반응에 관한 약리학적 특징

정현옥,홍기환,Jung, Hyun-Ok,Hong, Ki-Whan 대한약리학회 1983 대한약리학잡지 Vol.19 No.2

가토의 문맥 절편에서 비 코린성-비 아드레나린성 이완반응에 대한 약리학적 성질을 규명하여 다음과 같은 결과를 얻었다. 1) 가토 문맥 절편에 있어서 비 코린성-비 아드레나린성 전기자극반응은 자극빈도의 증가에 따라 예민하게 증가하였으며, $Ca^{++}$에 이하여 크게 영향을 받았고, $Ca^{++}$농도를 달리하고 ATP를 첨가하여 이완반응은 일어났으나 이는 전극자극에 의한 반응에는 영향을 주지 아니하였다. 2) ATP, ADT 및 adenosine에 대한 반응은 용량에 의존하여 이완반응은 보였으나 자극에 의한 반응에는 크게 영향을 미치지 아니하였다. 3) Quinine과 isobutyl-methyl xanthine을 투여하였을 때 용량에 따라 긴장도의 하강을 나타내었을 뿐 이완반응은 길항하지 아니하였다. 4) 4-AP, $1{\mu}g/ml$존재하에서 전기자극에 대한 이완반응 폭은 서서히 증가하였고 대량의 4-AP에 의하여 는 긴장도가 하강하였다. 5) 4-AP반복투여후의 전기자극에 이한 반응은 대조군과 비교하여 큰 변화가 없었으나, adenosine을 반복투여하였을 때는 대조군에 비하여 증가를 나타내었다. 6) $^3H-purine$의 유출은 전기자극에 의하여는 경미하나 ATP나 adenosine투여로 현저히 증가하였으며, 4-AP, TTX 및 adenosine 반복투여후에도 $^3H-efflux$의 변동을 나타내지 아니하였다. In this isolated study, it was aimed to elucidate the pharmacological properties of non-cholinergic, non-adrenergic inhibitory responses in the longitudinal strips of rabbit portal vein. 1) The portal vein responded inhibitory to electrical field stimulation in a frequency - and calcium-dependent manner after pretreatment with atropine, guanethidine and ergotamine, simultaneously. 2) When exogenous ATP, ADP, adenosine and cyclic AMP were added, respectively, they only showed the relaxations in the higher concentration without mimicing or affecting the inhibitory response induced by the electrical stimulation. The antagonist of purine substances, neither quinine nor isobutyl-methyl xanthine did influence on the relaxation. 3) The inhibitory response was significantly increased in the presence of $1{\mu}g/ml 4-amino-pyrineine (4-AP) which is $K^+-conduction$ blockade, but higher concentration of 4-AP directly decreased the vascular tone. 4) Though repeated application of ATP revealed the inhibitory effect on the relaxation, however, that of adenosine resulted rather increase of the amplitude. 5) After pretreatment with $^3H-adenosine$, $^3H-efflux$ induced by ATP or adenosine was markedly enhanced, but the electrical stimulation caused less $^3H-efflux$. 6) ^3H-efflux by electrical stimulation was not affected by the administration 4-AP, tetrodotoxin and adenosine.

전통적 여성성의 지속과 변모

정현옥(Jung Hyun-Ok) 실천민속학회 2005 실천민속학연구 Vol.7 No.-

The modernization of Korea has the dual aspect. One is the planned modern subject characterized by ‘finding individual’, the other is the harsh experience of colonial domination. Women in colonized Korea had never been assimilated by both way of life and remained ‘the Others’. This study focused on the life of women in colonial age in the middle of the huge tide of social transition through the life stories of old woman whose gender is a male. This Kim Young-Ja’s stories shows the life of woman in the margin status, East vs West, Woman vs Man, Urban vs countryside dichotomy and conflict between Modern and Tradition in the contradictory structure. In this story, teller judged other women’s life with traditional criteria, but with the story goes on, expressed changed attitude to her woman sexuality. Though even in present, the idea of patriarchism still rule and characterize the woman sexuality and almost all of them internalize their sexuality in this measure. When we think of the origin of Modernization stressing on the man sexuality, the woman’s life stories has the important point and possibility of self-awareness taking her away from the fetters of man, family and society and building self-confidence as an individual in the time of transition between tradition and modern.

교정공무원의 정신질환 수용자 처우 시 겪는 심리적 경험: 현상학적 연구

정현옥 ( Jung Hyun-ok ) 한국정신간호학회 2023 정신간호학회지 Vol.32 No.4

Purpose: The purpose of this study was to find out the meaning of the psychological experience of correctional officers’ treatment of mentally ill prisoners and describe its essential structure. Methods: The Colazzi's phenomenological research methodology was used. Nine correctional officers participated in this study. To collect data, in-depth individual interviews were conducted from September 4 to October 3, 2023. Results: Four clusters of themes were identified; “feeling daunted by unawareness of mental illness”, “darkness caused by the tangle of vines inside the correctional facility walls”, “determined to overcome and face it head-on”, and “warmth emanating from the custody of mentally ill prisoners.”. Conclusion: Through the psychological experiences of correctional officers in dealing with individuals with mental illness, it was possible to understand the demands of knowledge, attitudes, and skills related to mental illness, as well as psychological and mental stress. It is necessary to establish an educational program and crisis response protocol for correctional officers to cultivate knowledge, attitudes, and skills related to mental illness, and to activate the mental health promotion program currently being implemented in correctional facilities.

알코올의존 환자의 자존감, 특성분노, 우울, 가족기능, 대인관계가 실존적 영적안녕감에 미치는 영향

정현옥 ( Hyun Ok Jung ),채영선 ( Young Sun Chae ),김희숙 ( Hee Sook Kim ) 한국간호과학회 정신간호학회(구 대한간호학회정신간호학회) 2015 정신간호학회지 Vol.24 No.1

Purpose: The aim of this study is to identify the factors influencing the existential spiritual well-being in the patients with alcohol dependence. Methods: The research design was a descriptive survey research with self-report questionnaire about existential spiritual well-being, self-esteem, trait anger, depression, family function, and interpersonal relations scale. Participants in the study were 240 patients with dependence who were collected randomly from 10 mental hospitals and 5 alcoholic centers and 1 alcoholics anonymous in Busan, Deagu city and Gyeongsangbuk-do and Gyeongsangnam-do region. Results: The forecasting regression model of existential spiritual well-bing appeared to be significant, the order of influencing factor was self-esteem (β=.36, p<.001), depression (β=-.38, p<.001), interpersonal relations (β=.18, p=.001), and not being employed for last one year (β=-.11, p=.007). Conclusion: The development of program which vitalizes the vocational rehabilitation and intervention is needed to increase the existential spiritual well-being of the patients with alcohol dependence by increasing the self-esteem and interpersonal relations and decreasing depression which are the major influencing factors.

베이비붐세대 남성들의 전인건강에 대한 태도 유형

정현옥(Jung, Hyun-Ok),신은정(Shin, Eun-Jeong),박경란(Park, Kyung-Ran),유광자(Yu, Kwang-Za),김희숙(Kim, Hee-Sook) 한국성인간호학회 2016 성인간호학회지 Vol.28 No.5

여성 생애담에 나타난 성과 사랑

정현옥(Jung Hyun-Ok) 실천민속학회 2006 실천민속학연구 Vol.8 No.-

This is a report of women’s sexuality and love in life stories gathered at the Shinsudo senior center’s speech stage program in Sacheon City, Gyeongsangnam-do. Since marriages officially permit women to have sex, female sexuality in the life stories is limited in the boundary of marriages. Women’s sex is not for love, but for ‘having a son’. Therefore, once women finish the duty, their sexuality is called as ‘non-sexual.’ Violations against this concept of female sexuality are considered as deviations. The example can be seen in Grandmother Sun Yee’s first marriage. She experienced love from her first marriage, which other women have never felt. However, she has considered the feeling as a deviation by herself, kept it as a secret, and abused herself for the lifetime. Finally she confessed her life story at the stage, and received enormous supports from other women. Through this process, participants show changes in their previous conception to that they accept the experiences of love and sex as a point of discovering their identities. For men, speaking about their love and sexuality is regarded as either heroic or dirty stories, but it is stories of questioning and answering identities for women. This study is aimed to return a very personal story of an individual, which can be disappeared with her death, to the public experience of a community, and to assure the power of storytelling that gives new viewpoint to people’s life.

또래도우미훈련 프로그램이 특성화고등학교 여학생의 실존적 영적안녕감, 또래관계 및 우울에 미치는 효과

정현옥 ( Hyun Ok Jung ),송회옥 ( Hoy Ok Song ),김미향 ( Mi Hyang Kim ),김희숙 ( Hee Sook Kim ) 한국간호과학회 정신간호학회(구 대한간호학회정신간호학회) 2015 정신간호학회지 Vol.24 No.4

Purpose: The aim of this study was to investigate the effects of a peer helper training program on existential spiritual well-being, peer relationship, and depression for students attending a specialized girls vocational high school. Methods: The participants were forty-two students attending a specialized girls vocational high school in D city. Data were collected form october 23 to December 24, 2013. To test the effects of the peer helper training program, the participants were divided into two mached groups, an experimental group (21) and a control group (21). Data were analyzed using x2-test, Fisher exact probability test, and t-test with the SPSS/WIN 12.0 program. Results: After attending the peer helper training program, significant differences between the experimental group and the control group were found for existential spiritual well-being (t=3.35, p=.002) and peer relationship (t=2.29, p=.028). However, there was no significant differences in depression between the two groups. Conclusion: The results indicate that the peer helper training program enhances existential spiritual well-being and peer relationship for students attending a specialized girls vocational high school. Therefore, this program is a good strategy that teachers and community mental health nurses can use to increase existential spiritual well-being and peer relationship of these high school girls.

분양전환 공공임대아파트의 분양가격의 적정성 : 강원도 속초시의 사례를 중심으로

정현옥(Jung, Hyun-Ok),장희순(Jang, Hee-Soon) 한국주거환경학회 2020 주거환경(한국주거환경학회논문집) Vol.18 No.2

The research is designed to offer reference for the government’s establishment and implementation of rental housing policies and to seek suggestions that both lessor and tenant can agree and co-exist in economic and social perspective, by analyzing the adequacy of housing satisfaction and sale prices in rent to ownership conversion through a direct survey of residents who have owned 10-year rental apartments. The study found that middle-aged people in their 40s or older, self-employed, non-regular workers, and those without jobs, relatively economically vulnerable with less than 3 million won in income, mostly reside in 10-year rental apartments. The satisfaction degree of Purchaser was found to be unsatisfactory overall, with the value of less than standard value 3 on the five-point scale of the Likert type. compared to size of the facility satisfaction and environmental satisfaction, residential and community satisfaction were relatively high. The reason for the acquisition rental apartments was the opportunity to prepare a home and the convenience of transportation, and 72.5% of the them were satisfied with the rent to ownership conversion price. Multi-regression analysis has shown that the adequacy of the sale price increases with the increase in the satisfaction of the size of the facility, and lower with the increases the satisfaction of the residential environment and community.

Antitumor and Immunological Effects of Bovine Thymic Extract

정용자,홍기태,정현옥,Chung, Yong Za,Hong, Gi Tae,Jung, Hyun Ok Korean College Of Clinical Pharmacy 1992 한국임상약학회지 Vol.2 No.1

Thymic extract showed antitumor effect to sarcoma mice with higher dose$(200{\mu}g/mouse/day$ i.p., 4weeks) but not with low dose$(5{\mu}g/mouse/day$ i.p., 6 weeks). Direct cytotoxicities were exhibited against sarcoma 180, L1210 and MOLT-4 by MTT assay. The spleen weight of mice were increased but the number of circulating lymphocytes were not increased after long-term(2 weeks) administration of thymic extract. Evaluating the mitogenesis by MTT assay. $\%$ absorbance of human lymphocytes was not increased by thymic extract. Cell cycle statistics of S phase and $G_2/M$ phase was not increased in the presence of that by PI staining. The formation of rosette was induced, irrespectively of exposure time short-term(l hour) and long-term(2 weeks). The population of mouse blood T-cell to bind Lyt2-antimonoclonal antibody and to $L_2T_4$ were increased after administration of thymic extract$(2-200{\mu}g/mouse/day)$. From the above results, it is suggested that thymic extract exerts antitumor activity by stimulating T cells to differeniate in vivo but not in vitro.

대학생의 자살사고 영향 요인

이성희(Lee, Sung-Hee),정현옥(Jung, Hyun-Ok),박경란(Park, Kyung-Ran),유준옥(You, Jun-Ok),하태희(Ha, Tae-Hi),김희숙(Kim, Hee-Sook) 한국간호교육학회 2015 한국간호교육학회지 Vol.21 No.2

Purpose: This study was conducted to explore the influence of academic institutional interest, open parent-adolescent communication, social (friend) support, and existential spiritual well-being on suicidal ideation of college students. Methods: The research design was descriptive survey research involving 285 college students in city G. Data was collected from May 18, 2011 to November 2, 2011 and analyzed using descriptive statistics, t-test, one-way ANOVA, Pearson correlation coefficient, and hierarchical regression analysis. Results: The findings reveal that suicidal ideation of college students was low, i.e., average score was 9.2±3.65 (possible range 5∼25). This study determined that suicidal ideation is negatively correlated with interest on the part of the academic institution, open parent-adolescent communication, social support from friends, and existential spiritual well-being. The extent of existential spiritual well-being was a significant predictor of suicidal ideation, controlling for general characteristics variables (gender, number of close friends, first supporter) and institutional interest, open parent-adolescent communication, and social support. Existential spiritual well-being accounted for 50% of the explanation of suicidal ideation of college students. Conclusion: Based on the outcomes of this study, designing an intervention program that emphasizes existential spiritual well-being in order to decrease suicidal ideation of tertiary education students is strongly recommended.