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이영란,정선효,박희근,정준현,이왕록 한국운동영양학회 2013 Physical Activity and Nutrition (Phys Act Nutr) Vol.17 No.1
The aim of this study was to compare the effectiveness between resveratrol supplementation and aerobic exercise training with a low fat diet on adipogenesis and inflammatory molecules in adipocytes of high fat diet-induced obese mice. C57BL/6 mice (4weeks old, n = 15) were fed a high fat diet (45% fat) for 12 weeks first and a low fat diet (10% fat) for 8 weeks later. The mice were divided into 3 groups: low-fat diet control (HLC; n = 5). low-fat diet with resveratrol (HLR; n = 5) or low-fat diet with exercise (HLE; n = 5). HLE performed treadmill running for 30-60 min/day at 10-22 m/min, 0% grade, five times per week for 8 weeks. After 20 weeks of intervention, epididymal pads were dissected and analyzed. The body weight and adipose tissue mass of HLE was significantly reduced compared to HLC (p < 0.01). FAS expression of HLR and HLE were significantly decreased compared to HLC (p < 0.01). ACC expression of HLE was significantly decreased compared to HLC (P < 0.01). The TNF-a expression of HLR and HLE were significantly decreased compared to HLC (P < 0.01). MCP-1 expression of HLE was significantly decreased compared to HLC (p < 0.05). These results suggest that both aerobic exercise and resveratrol supplementation with a low-fat diet have a positive effect to ameliorate the obese-induced metabolic disturbances compared to a low fat diet alone. However, it seems that aerobic exercise with a low fat diet is more effective to obese-induced metabolic deregulation.