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정주양 ( Ju-yang Jung ),서창희 ( Chang-hee Suh ) 대한내과학회 2017 대한내과학회지 Vol.92 No.2
Osteoporosis is a common adverse event among patients on glucocorticoid therapy. Glucocorticoids reduce bone formation and increase cortical porosity in proportion to the dose and duration of glucocorticoid use. While the epidemiology of glucocorticoid-induced osteoporosis has been well characterized, its pathophysiology and effective management remain unclear. Several recommendations for glucocorticoid-induced osteoporosis are used to determine which patients on long-term glucocorticoid treatment to treat and when. The fracture risk can be assessed using dual-energy X-ray absorptiometry and the Fracture Risk Assessment Tool algorithm, along with other clinical factors. The management of glucocorticoid-induced osteoporosis includes anti-osteoporotic therapy and measures to prevent bone loss. Bisphosphonates are currently the first choice treatment, with teriparatide and denosumab being alternatives. (Korean J Med 2017;92:142-149)
정주양 ( Ju Yang Jung ),서창희 ( Chang Hee Suh ) 대한류마티스학회 2015 대한류마티스학회지 Vol.22 No.3
We reviewed the recent findings in diagnosis, pathogenesis and management of Sjogren``s syndrome. New diagnostic classification criteria for Sjogren``s syndrome were published by the American College of Rheumatology in 2012, and validation was completed. Salivary gland ultrasonography has been examined as a diagnostic and prognostic marker for Sjogren``s syndrome, and the results have revealed that it has high specificity and low sensitivity. Disease activity assessment tools for Sjogren``s syndrome have been developed and validated for upcoming clinical trials. Several associated genes were identified by genome-wide association studies, with large cohorts in Europe and China. Several single nucleotide polymorphisms of Sjogren``s syndrome are related to germinal center formation and lymphoma development. New treatment modalities, including interleukin-1 receptor antagonist, anti-CD20, anti-BAFF/Blys, and CTLA4-immunoglobulin were investigated, but the optimal therapeutic compounds have yet to be found. (J Rheum Dis 2015;22:146-153)
델파이 기법을 이용한 관광안전지수 개발: 여행안전척도를 중심으로
황정주 ( Hwang Jung-ju ),양진연 ( Yang Jin-youn ),안현영 ( Ahn Hyun-young ) 경남대학교 산업경영연구소 2018 지역산업연구 Vol.41 No.3
본 연구는 체계적인 관광안전정책과 관리를 수립하고, 건전한 안전관광문화를 정착시키고자 여행안전척도 개발을 목적으로 하였다. 여행안전척도는 선행연구에서 검토된 안전관련 척도를 참고하였으며, 여행산업계와 관광학계 전문가를 대상으로 델파이 기법을 이용하여 평가항목을 구성하였다. 평가 항목에 대한 가중치는 AHP기법을 활용하여 산출하였으며 연구결과는 다음과 같다. 첫째, 여행안전척도는 안전교육, 안전기술, 안전규제, 그리고 안전환경의 4개 요소, 20개 평가항목을 도출하였다. 둘째, 도출된 세부 평가항목에 대해 AHP 기법과 델파이 기법을 활용하여 세부항목별 가중치를 산출하였다. 안전교육은 0.38, 안전기술이 0.22, 안전규제는 0.15, 안전환경은 0.25점으로 산출되었다. 셋째, 여행안전척도 문항은 1차 전문가 조사에서는 5개 영역으로 실시하였지만, 안전평가와 안전환경의 조작적 정의가 중첩된다는 의견이 제시되었다. 따라서 안전평가와 안전환경을 묶여서 안전환경으로 일원화하였다. 본 연구를 통하여 국민의 행복한 여행을 위한 정책 마련에 타당성을 제공하고, 관광산업계에서 안전한 관리와 대책을 수립하는데 이론적 근거를 제시한 의미있는 결과를 도출하였다. This study developed a travel safety scale to establish a systematic tourism safety policy and management as well as a healthy safety tourism culture. The travel safety scale have applied the safety-related scales reviewed in the previous research, and the evaluation items were constructed with the travel industry experts and tourism academics based on Delphi method, while the weight for the evaluation items was calculated through the AHP technique. The results of the study are as follows: First, the travel safety scale derived 20 items in 4 categories including safety education, safety technique, safety regulation, and safety environment. Second, the weight for each item was calculated using the AHP technique and the Delphi technique. Safety education was 0.38, safety technology was 0.22, safety regulation was 0.15 and safety environment was 0.25. Third, the questionnaire for the travel safety scale was conducted in five domains in the first expert survey, but it was suggested that the operational definitions of safety assessment and safety environment were overlapping. Thus the safety assessment and the safety environment are combined into a safety environment. The results of this study will provide the rationale for the establishment of policies that can support people’s happy travel as well as the formation of safety management and countermeasures in the tourism industry.
김동훈 ( Dong Hoon Kim ),김정은 ( Jeong Eun Kim ),황의경 ( Eui Kyung Hwang ),정주양 ( Ju Yang Jung ),진현정 ( Hyeon Jeong Jin ),김주희 ( Joo Hee Kim ),예영민 ( Young Min Ye ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.4
Background: Petroleum-based solvents have been widely used for dry cleaning in Korea. Although there has been a few reports of irritant contact dermatitis induced by petroleum- based dry cleaning solvents, this is the first case of contact dermatitis with peripheral eosinophilia in Korea. Case History: A 53 year old man had suffered from itching sensation, erythema and bullae in both arms. The onset time was 1 hour after wearing a jacket which had been dry cleaned the day earlier. The skin lesions were localized to the area in contact with the jacket, and the Nikolsky sign was seen. The patient had no history of previous allergic diseases. Results: Serum total IgE levels, peripheral eosinophil counts, eosinophil cationic protein levels and liver function test results (aspartate and alanine transaminase) were elevated. Histopathological examination of the skin biopsy specimen showed epidermal necrosis with superficial perivenular lymphocytic and eosinophilic infiltration. He was negative for the patch test with maximum 1% of the solvent used at that laundry, which was composed of paraffin and naphten. Therefore, we thought that his skin lesion may be attributed to irritant reactions to this solvent. Conclusion: We report herein a case of contact dermatitis induced by a petroleum-based dry cleaning solvent. (Korean J Asthma Allergy Clin Immunol 2011;31:295-299)
루푸스 신장염이 있었던 환자의 임신 중 루푸스 신장염 악화
전자영 ( Ja Young Jeon ),서창희 ( Chang Hee Suh ),김현아 ( Hyoun Ah Kim ),정주양 ( Ju Yang Jung ),이주호 ( Joo Ho Lee ),강은정 ( Eun Jung Kang ),임현이 ( Hyun Ee Yim ) 대한류마티스학회 2013 대한류마티스학회지 Vol.20 No.5
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that predominantly affects women of reproductive age. Risk of SLE flare during pregnancy is dependent on disease activity of SLE and proteinuria at the time of conception, which affect pregnancy outcome. We report on three patients who developed renal flares during pregnancy after remission of lupus nephritis before pregnancy. Two patients were treated successfully, with pregnancy outcomes of live births however, another patient`s pregnancy was terminated with induced abortion. For SLE patients, family planningis needed until disease activity of SLE has been stable for at least six months prior to the pregnancy. Nevertheless, flares of lupus could develop and influence maternal and fetal outcome. Therefore, renal flares during pregnancy should be recognized and treated immediately.
전신홍반루푸스에 동반된 이차성 혈구포식성 림프조직구증 3예
임은수 ( Eunsoo Lim ),김영건 ( Young Geon Kim ),최원선 ( Won Sun Choi ),정유석 ( Yu Soek Jung ),한재호 ( Jae Ho Han ),배창범 ( Chang Bum Bae ),정주양 ( Ju Yang Jung ),김현아 ( Hyoun Ah Kim ),서창희 ( Chang Hee Suh ) 대한류마티스학회 2015 대한류마티스학회지 Vol.22 No.3
Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder characterized by fever, pancytopenia, hyperferritinemia, and phagocytosis of hematopoietic cells in bone marrow, liver, or lymph nodes. HLH can occur during the course of systemic lupus erythematosus (SLE), but can also be a presenting manifestation. Because development of pancytopenia occurs in less than 10 percent of SLE cases, investigation for HLH is necessary when otherwise unexplained pancytopenia persists despite adequate treatment. We experienced three cases of secondary HLH associated with SLE. Among the three patients, two patients developed HLH during the clinical course of SLE. The other patient who presented with pancytopenia was first diagnosed with HLH, and later with SLE. In her case, HLH turned out to be a presenting manifestation of SLE. We report on three successfully treated cases, and discuss the prevalence, characteristics, treatments, and prognosis of secondary HLH associated with SLE. (J Rheum Dis 2015;22:180-185)
혈청양성 류마티스관절염 환자에서 급성 신부전을 동반한 다발성 골수종
이승경 ( Seung Kyung Lee ),황선혁 ( Sun Hyuk Hwang ),박주한 ( Joo Han Park ),송가원 ( Ga Won Song ),박선영 ( Sun Young Park ),김세란 ( Sei Rhan Kim ),정주양 ( Ju Yang Jung ),배창범 ( Chang Bum Bae ),김현아 ( Hyoun Ah Kim ),정성현 대한류마티스학회 2014 대한류마티스학회지 Vol.21 No.5
It is known that rheumatoid arthritis (RA) patients show increased incidence of multiple myeloma (MM), despite its rarity. Only one case of MM with seronegative RA was reported in Korea, thus far. We report a case of MM with seropositive RA. The patient was a 66 year old female who had been diagnosed with seropositive RA 4 years ago. Over the last 1 month, the patient experienced general weakness and weight loss of 10 kg. It was found that her serum creatinine had increased and her urine analysis showed proteinuria. To evaluate renal failure and proteinuria, renal biopsy, bone marrow biopsy and electrophoresis were carried out. A diagnosis of myeloma cast nephropathy was made. We report this rare case of MM represented as acute renal failure during the treatment for RA, and include a review of the literature.