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고해상도 연속절단면 컬러해부영상을 이용한 한국인 성인여성 복셀팬텀 VKH-Woman 개발
정종휘,염연수,한민철,김찬형,함보경,황성배,김성훈,이동명,Jeong, Jong Hwi,Yeom, Yoen Soo,Han, Min Cheol,Kim, Chan Hyeong,Ham, Bo Kyoung,Hwang, Sung Bae,Kim, Seong Hoon,Lee, Dong-Myung 한국의학물리학회 2012 의학물리 Vol.23 No.3
전신에 대해 방사선에 민감한 주요장기가 미리 정의된 인체 전산팬텀(compuational human phantom)은 의료분야에서 방사선 치료에 의한 이차암 위험도 평가 및 진단방사선에 의한 유효선량 평가 등에 유용하게 활용될 수 있다. 본 연구에서는 한국인 여성사체에 대한 고해상도 연속절단면 컬러해부영상을 이용하여 장기 및 조직을 전신에 걸쳐 약 2 mm 간격으로 정밀하게 분할하였고, 이를 이용하여 몬테칼로 전산모사에 사용될 수 있는 VHK-Woman 복셀팬텀을 개발하였다. VKH-Woman 복셀팬텀은 키 160 cm, 몸무게 52.72 kg으로 한국인 여성의 표준체형에 가까우며, 유효선량을 계산할 수 있도록 ICRP 103에 제시된 27개 장기 및 기타 관심장기 12개를 포함한다. VKH-Woman의 복셀 해상도는 $1.976{\times}1.976{\times}2.0619mm^3$이며 복셀행렬의 크기는 $261{\times}109{\times}825$이고, 몬테칼로 코드에 입력하여 사용될 수 있도록 이진파일과 ASCII 파일 형식으로 데이터화되었다. The computational human phantom including major radiation sensitive organs at risk (OARs) can be used in the field of radiotherapy, such as the variation of secondary cancer risks caused by the radiation therapy and the effective dose evaluation in diagnostic radiology. The present study developed a Korean adult female voxel phantom, VKH-Woman, based on serially sectioned color slice images of Korean female cadaver. The height and weight of the developed female voxel phantom are 160 cm and 52.72 kg, respectively that are virtually close to those of reference Korean female (161 cm and 54 kg). The female phantom consists of a total of 39 organs, including 27 organs recommended in the ICRP 103 publication for the effective dose calculations. The female phantom composes of $261{\times}109{\times}825$ voxels (=23,470,425 voxels) and the voxel resolution is $1.976{\times}1.976{\times}2.0619mm^3$ in the x, y, and z directions. The VHK-Woman is provided as both ASCII and Binary data formats to be conveniently implemented in Monte Carlo codes.
김성훈,정종휘,구영모,정재린,조성구,조광현,김찬형 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.3
In proton therapy, a highly conformal proton dose can be delivered to the tumor by means of the steepdistal dose penumbra at the end of the beam range. The proton beam range, however, is highly sensitiveto range uncertainty, which makes accurately locating the proton range in the patient difficult. In-vivorange verification is a method to manage range uncertainty, one of the promising techniques beingprompt gamma imaging (PGI). In earlier studies, we proposed gamma electron vertex imaging (GEVI),and constructed a proof-of-principle system. The system successfully demonstrated the GEVI imagingprinciple for therapeutic proton pencil beams without scanning, but showed some limitations underclinical conditions, particularly for pencil beam scanning proton therapy. In the present study, weupgraded the GEVI system in several aspects and tested the performance improvements such as forrange-shift verification in the context of line scanning proton treatment. Specifically, the system showedbetter performance in obtaining accurate prompt gamma (PG) distributions in the clinical environment. Furthermore, high shift-detection sensitivity and accuracy were shown under various range-shift conditionsusing line scanning proton beams.
김성훈,정종휘,구영모,정재린,김찬형 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.6
The maximum dose delivery at the end of the beam range provides the main advantage of using protontherapy. The range of the proton beam, however, is subject to uncertainties, which limit the clinicalbenefits of proton therapy and, therefore, accurate in vivo verification of the beam range is desirable. Forthe beam range verification in spot scanning proton therapy, a prompt gamma detection system, calledas gamma electron vertex imaging (GEVI) system, is under development and, in the present study, theperformance of the GEVI system in spot scanning proton therapy was predicted with Geant4 Monte Carlosimulations in terms of shift detection sensitivity, accuracy and precision. The simulation results indicated that the GEVI system can detect the interfractional range shifts down to 1 mm shift for the casesconsidered in the present study. The results also showed that both the evaluated accuracy and precisionwere less than 1e2 mm, except for the scenarios where we consider all spots in the energy layer for alocal shifting. It was very encouraging results that the accuracy and precision satisfied the smallest distalsafety margin of the investigated beam energy (i.e., 4.88 mm for 134.9 MeV).