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유전자 2형인 만성 C형간염 환자에서 페그인터페론과 리바비린의 단기간 치료 효과
정은욱 ( Eun Uk Jung ),박지훈 ( Ji Hun Park ),배경임 ( Kyung Im Pae ),강석우 ( Suk Woo Kang ),박성재 ( Sung Jae Park ),지삼룡 ( Sam Ryong Jee ),박은택 ( Eun Tak Park ),이연재 ( Youn Jae Lee ),이상혁 ( Sang Hyuk Lee ),설상영 ( Sang 대한간학회 2007 Clinical and Molecular Hepatology(대한간학회지) Vol.13 No.3
RF sputter를 이용한 실리카 증착 고 내구성 반사 방지막 제조
전성권,정은욱,나종주,권정대,Jeon, Seong-Gwon,Jeong, Eun-Uk,Rha, Jong-Joo,Kwon, Jung-Dae 한국표면공학회 2019 한국표면공학회지 Vol.52 No.2
We fabricated durable anti-reflective(AR) layer with silica globular coating on polymer by two steps. Firstly, nano-protrusions of polymer were formed by plasma etching known as R.I.E(reactive ion etching) process. Secondly, silica globular coating was deposited on polymer nano-protrusions for mechanically protective and optically enhancing AR layers by RF magnetron sputter. And then durable antireflective polymers were synthesized adjusting plasma power and time, working pressures of RIE and RF sputtering processes. Consequently, we acquired the average transmission (94.10%) in the visible spectral range 400-800 nm and the durability of AR layer was verified to sustain its transmission until 5,000 numbers by rubber test at a load of 500 gf.
내시경역행담췌관조영술에서 조영제 주입 전 담즙 흡인의 임상적 효과
최정식 ( Jung Sik Choi ),강대환 ( Dae Hwan Kang ),김현대 ( Hyun Dae Kim ),엄상화 ( Sang Hwa Urm ),이상헌 ( Sang Heun Lee ),김지현 ( Ji Hyun Kim ),지삼룡 ( Sam Ryong Jae ),정은욱 ( Eun Uk Jung ),박성재 ( Sung Jae Park ),이연재 ( Yo 대한소화기학회 2012 대한소화기학회지 Vol.60 No.6
목적: 내시경역행담췌관조영술 후 담관염, 간기능의 악화, 담낭염, 췌장염 등의 합병증을 경험하게 된다. 이를 예방하기 위한 방법으로 조영제 주입 전 담즙을 일부 흡인함으로써 폐쇄 담관의 감압을 통한 이들 합병증의 빈도가 감소하는지를 알아보기 위하여 이번 연구를 시행하였다. 대상 및 방법: 2008년 12월 1일부터 2010년 6월 30일까지 3차 의료기관에서 내시경역행담췌관조영술을 시행한 988명의 환자 중 담관 조영술 전에 일정량의 담즙 흡인 후 조영제를 주입한 환자 102명과 통상적인 방법인 담즙 흡인 없이 조영제를 주입하여 담관 조영술을 시행한 대조군 115명을 대상으로 하여 시술 후 담관염, 간기능의 악화, 담낭염, 췌장염 등을 전향적으로 비교하였다. 결과: 조영제 주입전 담즙 흡입을 먼저 시행한 102명 중 담관염은 3명(2.9%), 시술 후 간기능 악화 4명(3.9%), 담낭염과 췌장염은 1명도 발생하지 않았다. 시술 후 복통 없이 혈청 아밀라제 증가만 보인 경우가 6명(5.8%)이었다. 대조군 115명 중에서 담관염은 1명(0.4%), 시술 후 간기능 악화소견을 보인 환자는 9명(7.8%), 췌장염은 3명(2.6%), 시술 후 복통 없이 혈청 아밀라제 증가만 보인 경우가 10명(8.6%)이었으며, 담낭염은 1명도 발생하지 않았다. 조영제 주입 전 담즙 흡입군과 대조군에서 시술 후 합병증의 유의한 차이를 보이지 않았다 (p>0.05). 결론: 담관 폐쇄 환자에서 내시경역행담췌관조영술을 시행할때 선택적 담관 삽관 후 일정량의 담즙을 흡인한 후에 조영제를 주입하여 담관조영술을 하는 경우에 시술 후 합병증 예방에 미치는 영향은 미미하였다. Background/Aims: This study was designed to determine whether bile aspiration before contrast injection cholangiogram prevent of post-ERCP cholangitis, liver function worsening, cholecystitis and pancreatitis. Methods: One hundred and two patients in the bile aspiration group before contrast injection from December 1, 2008 to December 30, 2009 and 115 patients in the conventional control group from January 1, 2010 to June 30, 2010 were analyzed. The incidence of post-ERCP cholangitis, liver function worsening, cholecystitis, pancreatitis, and hyperamylasemia only were compared between these two groups. Results: In the 102 patients with the bile aspiration group, post-ERCP cholangitis in 3 patients (2.9%), liver function worsening in 4 patients (3.9%), cholecystitis and pancreatitis in none, and hyperamylasemia only in 6 patients (5.8%) occurred. In the 115 patients with control group, post-ERCP cholangitis in 1 patient (0.4%), liver function worsening in 9 patients (7.8%), cholecystitis in none, pancreatitis in 3 patients (2.6%), hyperamylasemia only in 10 patients (8.6%) developed, The two groups did not significantly differ in terms of the incidence of post-ERCP cholangitis, liver function worsening, pancreatitis, and hyperamylasemia only (p>0.05). Conclusions: Initially bile juice aspiration just before contrast injection into the bile duct rarely prevented post-ERCP cholangitis, liver function worsening, and pancreatitis in patients with the extrahepatic bile duct obstruction.
우리나라 만성 C형간염 환자에서 페그인터페론과 리바비린의 병합치료에 대한 효과
강명주 ( Myoung Joo Kang ),정은욱 ( Eun Uk Jung ),박상원 ( Sang Won Park ),최바울 ( Pa Ul Choi ),김지현 ( Ji Hyun Kim ),박성재 ( Sung Jae Park ),박은택 ( Eun Taek Park ),이연재 ( Youn Jae Lee ),이상혁 ( Sang Hyuk Lee ),설상영 ( Sa 대한간학회 2008 Clinical and Molecular Hepatology(대한간학회지) Vol.14 No.3
크론병과 장결핵의 감별에 있어 특징적인 대장내시경 소견
제인수 ( In Soo Je ),이상혁 ( Sang Hyuk Lee ),정은욱 ( Eun Uk Jung ),강명주 ( Myoung Joo Kang ),박상원 ( Sang Won Park ),최바울 ( Pa Ul Choi ),김지현 ( Ji Hyun Kim ),박성재 ( Sung Jae Park ),지삼룡 ( Sam Ryong Jee ),박은택 ( Eun T 대한장연구학회 2007 Intestinal Research Vol.5 No.2
Background/Aims: The incidence of Crohn``s disease (CD) is on the increase in Korea. The differentiation of Crohn``s disease from intestinal tuberculosis (IT) is difficult. The aim of this study is to determine the characteristics of colonoscopic findings and factors that differentiate CD from IT. Methods: A total of 136 patients who were diagnosed with CD or IT at the Busan Paik Hospital from January 1995 to May 2005 were included in this study. We analyzed endoscopic findings, clinical characteristics and histological findings of 75 patients with CD and 61 patients with IT retrospectively. Results: For patients with IT, 18 (58.1%) of the patients had circular ulcers. For patients with CD, 27 (42.1%) of the patients had transverse ulcers, 18 (28.1%) of the patients had longitudinal ulcer, and 19 (29.6%) of the patients had both types of ulcers. The involvement of the ileocecal valve was noted in 18 (58.0%) of the patients with CD and in 37 (57.8%) of the patients with IT. The involvement of the rectum or anus was noted in 24 (51.5%) of the patients with CD and one (3.2%) patient with IT. Conclusions: According to previous studies, the presence of an ulcer was important to differentiate CD from IT. However, the presence of an ulcer was not a significant differentiating factor in our study. On colonoscopic findings, involved segments, an aphthous ulcer, cobblestone appearance, involvement of the rectum or anus and mucosal bridge should be observed carefully. (Intest Res 2007;5:158-164)
치료 전 바이러스 농도가 낮고 조기바이러스 반응이 있는 유전자 1형 만성 C형간염은 24주 페그인터페론과 리바비린 치료도 가능할 수 있다
문성수 ( Sung Soo Moon ),강현구 ( Hyoun Gu Kang ),서정아 ( Jeong Ah Seo ),정은욱 ( Eun Uk Jung ),이상헌 ( Sang Heon Lee ),박성재 ( Sung Jae Park ),이연재 ( Youn Jae Lee ),설상영 ( Sang Yong Seol ) 대한소화기학회 2010 대한소화기학회지 Vol.56 No.1
Background/Aims: The standard treatment for chronic hepatitis C infected with hepatitis C virus (HCV) genotype 1 is a combination of pegylated interferon alfa and ribavirin over a 48 weeks period. It is unclear if 24 weeks treatment is possible for patients showing a rapid virological response (RVR) without compromising the sustained virological response (SVR) in Korea. Methods: Between June 2005 and September 2008, among patients chronically infected with the HCV genotype 1 who were treated with pegylated interferon alfa subcutaneously once weekly plus ribavirin based on body weight, 55 patients who had low pretreatment viral load (<600,000 IU/mL) and RVR were enrolled. A total of 55 patients were divided into 24 weeks treatment group (n=29) and the standard treatment group (n=26). The HCV RNA was quantitatively assessed before treatment, and after 12 weeks of treatment, and also qualitatively assessed after 4 weeks of treatment, at end of treatment (24 weeks), and 24 weeks after end of treatment. RVR was defined as undetectable HCV RNA at the 4 weeks of treatment. Results: Among the 55 patients, SVR was achieved in 100% (29/29) of the patients in 24 weeks treatment and 96.2% (25/26) of the patients in the standard treatment (p=0.473). Conclusions: HCV genotype 1 infected patients with a low baseline HCV RNA concentration who become HCV RNA negative at week 4 may be treated for 24 weeks without compromising sustained virlolgical response. However, an additional trial will be needed to optimize the treatment duration. (Korean J Gastroenterol 2010;56:33-38)
침습선암의 조직소견이 동반된 혼합형 증식성 선종성 직장용종 1예
서효림 ( Hyo Rim Seo ),김지현 ( Ji Hyun Kim ),정수진 ( Soo Jin Jung ),최윤정 ( Yun Jung Choi ),류충헌 ( Choong Heon Ryu ),박관식 ( Kwan Sik Park ),하승인 ( Seoung In Ha ),정은욱 ( Eun Uk Jung ),이상헌 ( Sang Heon Lee ),박성재 ( Su 대한장연구학회 2012 Intestinal Research Vol.10 No.3
Epithelial colon polyps are largely divided into hyperplastic and adenomatous polyps. Adenomatous polyps are premalignant lesions, whereas hyperplastic polyps are regarded as benign lesions. However, this histological classification has been blurred, as cases of malignant changes in hyperplastic polyposis, mixed hyperplastic adenomatous polyps (MHAPs), and serrated adenomas in the colon have been reported. Rare cases of MHAP have been reported, and are mainly found at the proximal colon with a relatively large size. MHAPs seem to be an intermediate stage of the hyperplastic polyp-adenoma sequence or a collision tumor. Here, we report on a case of a single polyp in the rectum diagnosed with a MHAP combined with an invasive adenocarcinoma. (Intest Res 2012;10:295-299)
정은욱,지삼룡,이영태,박지훈,김동기,제인수,채두근,박성재,박은택,이연재,이상혁,설상영,정정명 白中央醫療院 2005 仁濟醫學 Vol.26 No.1
Afferent loop syndrome is an uncommon complication of a gastrectomy and Billroth Ⅱ reconstruction. It may cause symtoms at any time from the first postoperative day to many years after the gastrectomy. Afferent loop syndrome is characterized by abdominal pain, vomiting and elevation of serum amylase. Thus, it is difficult to differentiate afferent loop syndrome from other cause of acute pancreatitis. However, the history of gastrectomy can be an important clue for diagnosing afferent loop syndrome. We experienced one case of chronic afferent loop syndrome with acute pancreatitis. After appropriate management, the abdominal pain disappeared and serum amylase level decreased. We report this case with a review of relevant literatures.