http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Inhibitory Effects of Mung Bean (Vigna radiata L.) Seed and Sprout Extracts on Melanogenesis
정유민,하지훈,노근영,박수남 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.2
Inhibitory effect against melanogenesis and the in vitro tyrosinase inhibitory activity of ethyl acetate (EtOAc) and methylene chloride fractions of 80% methanol extracts of mung bean (Vigna radiata L.) seeds and sprouts were determined. EtOAc extract fractions from mung bean sprouts germinated for 12 h (33.5%), 1 day (56.5%), and 2 days (47.9%) inhibited melanogenesis more effectively than arbutin (16.3%). The in vitro tyrosinase inhibitory activity was higher in an EtOAc extract fraction from mung bean sprouts germinated for 2 days (70.5%). EtOAc extract fractions from mung bean sprouts germinated for 1 day showed excellent whitening effects due to the flavone vitexin. Extracts from mung bean sprouts germinated for 1 day can be used as a novel whitening cosmeceutical ingredient.
정유민,김혜정,박재홍,양경무 대한법의학회 2016 대한법의학회지 Vol.40 No.4
Dehumidifying agents are commonly used to remove moisture and odors and are not meant for oral ingestion. The hazards of accidental oral ingestion of dehumidifying agents are not well known. A 31-year-old man with autism drank the liquid desiccant contained in the barrel of a dehumidifier while sleepwalking. The desiccant mainly consisted of calcium chloride. He was taken to the emergency center with persistent vomiting and underwent gastric lavage. The patient was treated for hypercalcemia due to calcium chloride poisoning. He eventually died of multiple organ failure. Autopsy findings were as follows: acute suppurative pneumonia, intra-abdominal inflammation, liver necrosis, acute pancreatitis, and gastrointestinal hemorrhage. Calcium chloride has relatively low toxicity; however, when ingested orally, it can cause severe internal damage, and even death. We suggest active preventive measures to ensure the safe use of dehumidifying agents.
골수 줄기세포와 주사형 MPEG-PCL diblock copolymer를 이용한 조직공학적 골재생
정유민,이태형,박정균,김원석,신주희,이의석,임재석,장현석,Jeong, You-Min,Lee, Tai-Hyung,Park, Jeong-Kyun,Kim, Won-Suk,Shin, Joo-Hee,Lee, Eui-Seok,Rim, Jae-Suk,Jang, Hyon-Seok 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.1
Aim of the study: As an injectable scaffold, MPEG-PCL diblock copolymer was applied in bone tissue engineering. In vivo bone formation was evaluated by soft X-ray, histology based on the rat calvarial critical size defect model. Materials and Methods: New bone formation was evaluated with MPEG-PCL diblock copolymer in rat calvarial critical size bone defect. No graft was served as control. 4, 8 weeks after implantation, gross evidence of bone regeneration was evaluated by histology and soft X-ray analysis. Results: The improved and effective bone regeneration was achieved with the BMP-2 and osteoblasts loaded MPEG-PCL diblock copolymer. Conclusion: It was confirmed that MPEG-PCL temperature sensitive hydrogels was useful as an injectable scaffold in bone regeneration.
정유민,하지훈,박수남 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.35 No.-
Solid lipid nanoparticles consisting of cationic lipids were prepared for effective delivery of luteolin, andevaluated their physical characteristics and cytoprotective effects against ultraviolet A (UVA) radiationand H2O2 in HaCaT cells. This study reports that triple-tailed CSLN can enhance transdermal delivery ofluteolin with high entrapment efficiency, slow release kinetic without initial burst. Further, it showedhigh intracellular uptake, provided the highest degree of the cytoprotective effects of LT-CSLNs (83.10%,77.65%) as compared to non-treated groups (60.85%, 52.70%) against UVA and H2O2. These resultssuggested that LT-CSLN3 could be used as an effective transdermal delivery system for luteolin.
The Smad4/PTEN Expression Pattern Predicts Clinical Outcomes in Colorectal Adenocarcinoma
정유민,위영찬,김예슬,방성식,양정호,장기석,민경환,백승삼 대한병리학회 2018 Journal of Pathology and Translational Medicine Vol.52 No.1
Background: Smad4 and PTEN are prognostic indicators for various tumor types. Smad4 regulates tumor suppression, whereas PTEN inhibits cell proliferation. We analyzed and compared the performance of Smad4 and PTEN for predicting the prognosis of patients with colorectal adenocarcinoma. Methods: Combined expression patterns based on Smad4+/– and PTEN+/– status were evaluated by immunostaining using a tissue microarray of colorectal adenocarcinoma. The relationships between the protein expression and clinicopathological variables were analyzed. Results: Smad4–/PTEN– status was most frequently observed in metastatic adenocarcinoma, followed by primary adenocarcinoma and tubular adenoma (p < .001). When Smad4–/PTEN– and Smad4+/PTEN+ groups were compared, Smad4–/PTEN– status was associated with high N stage (p = .018) and defective mismatch repair proteins (p = .006). Significant differences in disease-free survival and overall survival were observed among the three groups (Smad4+/PTEN+, Smad4–/PTEN+ or Smad4+/PTEN–, and Smad4–/PTEN–) (all p < .05). Conclusions: Concurrent loss of Smad4 and PTEN may lead to more aggressive disease and poor prognosis in patients with colorectal adenocarcinoma compared to the loss of Smad4 or PTEN alone.