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정원태,이인석,정혜정,Jung, Won-Tae,Lee, In-Suk,Jeong, Hae-Jeong 한국데이터정보과학회 1996 한국데이터정보과학회지 Vol.7 No.2
When we are estimate the smoothing parameter in spline regression model, we deal the diagnostic of influence observations as posteriori analysis. When we use Generalized Maximum Likelihood Function as the estimation method of smoothing parameter, we propose the diagnostic measure for influencial observations in the obtained estimate, and we introduce the finding method of the proper smoothing parameter estimate.
강한 한국 성인에서 ALDH2 유전형에 따라 Metadoxine(Alcotel ??)이 알코올의 약동학 및 약역학에 미치는 영향
윤진상(Jin-Sang Yoon),윤보현(Bo-Hyun Yoon),이용복(Yong-Bok Lee),신일선(Il-Seon Shin),정재성(Jae-Sung Jung),정원태Won-Tae Jung),시영화(Young-Hwa She) 한국중독정신의학회 2000 중독정신의학 Vol.4 No.1
Objectives:Metadoxine is known to have accelerated the metabolism of alcohol in previous studies with Caucasian subjects. The purpose of this study was to evaluate the effects of metadoxine on alcohol pharmacokinetics and pharmacodynamics in normal Korean adults according to the low-Km aldehyde dehydrogenase (ALDH2) genotypes. Methods:Twenty healthy male volunteers (half with active ALDH2*1/*1:active group, the other with inactive ALDH2*1/*2:inactive group) were selected by genotyping. In a double-blind, counterbalanced design, each subject ingested 0.5 g of alcohol per kg of body weight with pretreatment of metadoxine or placebo on 2 separate occasions. Blood alcohol concentration by breathanalyzer (BrAC), vital signs, negative physiological responses and performance function using a battery of tests (critical flicker fusion threshold:CFFT, choice reaction time:CRT, compensatory tracking task:CTT and digit-symbol substitution:DSS) were measured at baseline and repeatedly over a 3-hour period after intake of alcohol. Results:Among the pharmacokinetic parameters, Vmax and Km were significantly increased with pretreatment of metadoxine in both the active and inactive ALDH2 groups, but the ratio of Vmax/Km was decreased. In terms of pharmacodynamics, the pretreatment of metadoxine produced a significant improvement of performance such as CFFT and DSS in the active ALDH2 group, but did not in the inactive ALDH2 group. Conclusions:It may be concluded that metadoxine has little effect on alcohol metabolism in both groups with respect to pharmacokinetics on the basis of BrAC. The pharmacodynamic results, however, indicated that metadoxine might be partially effective in counteracting the impairing effects of alcohol on the performance in the active ALDH2 group.
정원태 ( Won-tae Jung ),정혜정 ( Hye-jung Jung ) 한국정보처리학회 2007 한국정보처리학회 학술대회논문집 Vol.14 No.1
소프트웨어 품질 평가를 함에 있어서 정량적이고 객관적인 소프트웨어의 품질 평가 방안을 제시하는 것은 상당히 중요하다. 현재 진행 중에 있는 소프트웨어 품질 평가 국제 표준 ISO/IEC 25000 프로젝트에서 제시하고 있는 품질 측정 프리미티브를 제시하고 이와 같은 품질 측정 프리미티브를 활용하여 소프트웨어 품질 평가를 실행할 수 있는 방안을 제시하려 한다.
전신성 홍반성 루푸스 환자에서 Total Anti-oxidant Capacity와 질병활성도의 상관성
정원태 ( Won Tae Chung ),이성원 ( Sung Won Lee ),김경희 ( Kyung Hi Kim ),김정만 ( Jung Man Kim ),김채기 ( Chae Gi Kim ),윤원찬 ( Wern Chan Yoon ),류재근 ( Jae Kean Ryu ),장성국 ( Sung Gug Chang ),송용호 ( Yong Ho Song ),최정윤 ( J 대한류마티스학회 2001 대한류마티스학회지 Vol.8 No.3
Objective: To determine the correlation between total anti-oxidant capacity (TAOC) and lipid peroxidase (LPO) levels in serum and disease activity in systemic lupus erythematosus (SLE). Methods: The study population consisted of 99 patients with SLE according to the 1982 revised ACR criteria and 83 healthy controls. The serum TAOC levels in 99 patients with SLE and 83 healthy controls by the ABTS(R) inhibition method (Randox Ltd, Antrim, UK) and serum malondialdehyde (MDA) levels in 37 out of 99 patients with SLE were measured. Anti-dsDNA antibody (anti-dsDNA), albumin, AST, ALT, cholesterol, uric acid and creatinine were measured to determine the association with the serum TAOC levels. The correlation between the serum TAOC levels and nephritis in 27 cases with nephritis out of 99 SLE patients was also investigated. The SLE disease activity was determined by the SLE disease activity index (SLEDAI) at the time of sample collection. Results: Compared to the controls (1.37±0.127mmol/L), serum TAOC levels were significantly decreased (1.29±0.124mmol/L) in SLE patients (p=0.001). And there was a negative correlation between serum TAOC levels and SLEDAI total scores in the SLE patients (r=-0.388, p=0.0001), but no significant correlation between TAOC levels and C3 and anti-dsDNA. Further, a significant difference (p<0.04) in TAOC levels was found in SLE patients with and without nephritis. In comparison with other parameters such as AST, ALT, and cholesterol which might change anti-oxidant level, there was no correlation between the serum TAOC levels and them, except for serum uric acid (r=0.387, p=0.0001), creatinine, and albumin (r=0.507, p=0.0001). Additionally, we couldn`t find significant correlation between the serum TAOC levels and MDA. Conclusions: The serum TAOC levels correlate significantly with SLE disease activity and are associated with nephritis. Also, this study showed a significant correlation with serum albumin levels in these patients. Conclusively, the measurement of the serum TAOC levels in patients with SLE will provide useful information on SLE disease activity.
한국의 목표가격 기준 농가손실 보전정책효과 및 한계분석
정원태 ( Jung Won-tae ),유영봉 ( Yu Young-bong ) 한국식품유통학회 2017 食品流通硏究 Vol.34 No.3
This article investigates a farm income loss compensation policy based on target prices in Korea. Under the policy that is based on target prices, farms receive payments when the average market price falls below target prices. We theoretically explore how the target price based policy cannot fully compensate individual farm income losses. We, then, use the production cost data of 400 Satsuma farms in Jeju to empirically examine who would benefit from the target price based policy and how the payments from the target price based policy reduce losses in farm income. We find that the target price based policy reveals a significant level of basis risk. Our findings suggest that the target price based policy may not fully compensate the income losses of farms. The policy needs to be modified to reduce the level of basis risk.
설문조사를 활용한 모바일 RFID 미들웨어 품질 평가 모델 개발에 대한 연구
정원태(Won-Tae Jung),정혜정(Hye-Jung Jung) 한국멀티미디어학회 2008 한국멀티미디어학회 학술발표논문집 Vol.2008 No.2
요즘 소프트웨어 품질 평가에 대한 관심이 높아지면서 소프트웨어 품질 평가에 대한 연구가 다양하게 진행되어지고 있다. 특히 소프트웨어 품질 평가에 대한 표준연구가 새롭게 진행되어지면서 많은 분야에서 소프트웨어 품질 평가 모델 개발에 대한 연구를 하고 있다. 본 연구에서는 모바일 RFID 미들웨어에 대한 활용성이 우리 생활 전반에 높아지면서 소프트웨어 품질 평가에 대한 모델 개발을 연구하려 한다. 본 연구는 ISO/IEC 25000 시리즈 SQuaRE 프로젝트를 참고하여 모바일 RFID 미들웨어 품질 평가를 위한 매트력을 설문조사 결과를 활용하여 제시한다. 모바일 RFID 미들웨어에 대한 설문조사 결과를 통해서 제품에 대한 요구사항을 파악하고 모바일 RFID 미들웨어를 평가할 수 있는 채크리스트를 제시하여 분석된 요구사항을 모바일 RFID 미들웨어 품질 평가 모델에 적용할 수 있는 방안을 제시한다.