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      • KCI등재

        염산비퀴딜 캡슐 및 알리벤돌 정의 용출시험에 관한 연구

        정분(Joungboon Hwang),구은주(Eun Joo Koo),고서(Seu Youn Go),조경철(Kyung Chul Cho),문현주(Hyun-Ju Moon),조수열(Soo Yeul Cho),강찬순(Chan Soon Kang),손여원(Yeo Won Shon),김영옥(Young Ok Kim),손경희(Kyung Hee Sohn),조대현(Dae Hyun 대한약학회 2010 약학회지 Vol.54 No.5

        The dissolution test method and an analytical procedure by HPLC were developed and validated for viquidil hydrochloride capsules and alibendol tablets. These drugs were not yet characterized by the dissolution specifications in Korean Pharmaceutical Codex. So, with each reference and test drugs, we did the preliminary and standard experiments based on the Korean Pharmacopeia Guideline of dissolution testing for solid oral dosage forms. The dissolution test for viquidil hydrochloride capsules was carried out under sink conditions as follows: dissolution medium water, paddle rotation speed 50 rpm and vessel volume 900 ml. More than 90% of its label amount was released within 30 min in this method. Also the dissolution test for alibendol tablets was carried out under sink conditions as follows: dissolution medium water, paddle rotation speed 100 rpm and vessel volume 900 ml. More than 90% of its label amount was released within 45 min in this method. The dissolution samples were analyzed with a precise and accurate HPLC method. The developed dissolution test showed specificity, linearity, precision and accuracy within the acceptable range. The dissolution testing method described above was adequate for the purpose and may be proposed as a pharmacopeial standard to assess the performance of viquidil hydrochloride capsules and alibendol tablets.

      • KCI등재

        수산나프로닐 캡슐 및 염산트라마돌 캡슐의 용출시험에 관한 연구

        정분(Joung-Boon Hwang),문현주(Hyun-Ju Moon),고서(Seo Youn Go),장기욱(Gi-Uk Jang),이규하(Kyu Ha Lee),손경희(Kyung Hee Sohn),김인규(In-Kyu Kim),조대현(Dae Hyun Cho) 대한약학회 2011 약학회지 Vol.55 No.5

        The dissolution test method and an analytical procedure by HPLC were developed and validated for nafronyl oxalate capsules and tramadol hydrochloride capsules. These drugs were not yet characterized by the dissolution specifications in the Korean Pharmaceutical Codex. So, with each reference and test drugs, we did the preliminary and standard experiments based on the Korean Pharmacopeia Guideline of dissolution testing for solid oral dosage forms. The dissolution test for nafronyl oxalate capsules was carried out under sink conditions as follows: dissolution medium phosphate buffer pH 6.8, paddle rotation speed 100 rpm and vessel volume 900 ml. More than 80% of its label amount was released within 30 min in this method. Also the dissolution test for tramadol hydrochloride capsules was carried out under sink conditions as follows: dissolution medium water, paddle rotation speed 50 rpm and vessel volume 900 ml. More than 90% of its label amount was released within 15 min in this method. The dissolution samples were analyzed with a validated HPLC analytical procedure. The analytical methodology showed acceptable values in terms of specificity, linearity, precision and accuracy. The dissolution test methods described above were adequate for the purpose and may be proposed as a pharmacopeial standard to assess the performance of nafronyl oxalate capsules and tramadol hydrochloride capsules. Furthermore, the outcomes of this study were expected to help create an environment where safe and high quality drugs would be distributed on the domestic market making contributions to advancing public health.

      • KCI등재후보

        초.중.고 특수교육자녀를 돌보는 어머니의 스트레스, 우울 및 수면

        김현숙,정분,조미 韓國學校保健學會 2010 韓國學校保健學會誌 Vol.23 No.1

        Purpose: The purpose of this research is to identify stress, depression and sleeping of mothers with children who have received the special education in the elementary, middle and high school and to find out the relationship among stress, depression and sleeping. It will be provided as the basic information for development of nursing intervention. Methods: This research was carried out from November 18th to November 27th, 2009 through questionnaire about the stress, the depression and the sleeping. The subjects of investigation were 94 mothers with children who have received the special education in elementary school, middle and high school. Results: There is correlation between the psychological and physical stress of the mothers; correlation between the stress and the depression; inverse correlation between the stress and the sleeping; and inverse correlation between the depression and the sleeping significantly in statistics (p<.001). Mother group in elementary school has mild depression and the other variables in all groups of mothers are included in normal range. Conclusion: It is necessary to do the comparative study for stress, depression and sleeping of mothers with children who have received the special education in elementary school, middle and high school and to make the research for the development of optimized nursing intervention program for reducing depression for the subjects.

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