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68세 여자에서 발견된 Morgagni hernia 1예
정영일,정귀예,민영돈,김경종 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.3
Morgagni hernia is a herniation of abdominal viscera into the thoracic cavity through the sternocostal hiatus (foramen of Morgagni). It has the lowest occurrent rate of 3% among congenital diaphragmatic defects. Generally, the defect is present from the early embryonic period without apparent symptoms, but symptoms can occur with the defect growing in size in adult. We report a case of Morgagni hernia complaining of intermittent RUQ abdominal pain in 68-year-old women. In addition, we considered other related references with our case.
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장영주,주희재,양정인,서창원,정귀예,Gregory M. Lanza,Huiying Zhang 한국통합생물학회 2011 Animal cells and systems Vol.15 No.4
This study was undertaken to produce a F_(ab) fragment of a human monoclonal antibody reactive to oxidized and carbamylated low-density lipoprotein (oxLDL and cLDL) using phage display technology. An analysis of DNA sequences of this F_(ab), termed plaque 15,16-46 F_(ab), revealed that the rearranged VH was highly mutated. Complementarity-determining regions of the VH showed a very high R/S ratio and contained many positively charged amino acids. In direct binding and competitive ELISA, the F_(ab) reacted strongly with both MDA-LDL and Cu-oxLDL forms of oxLDL, and also showed high affinity for cLDL. Immunofluorescence and immunohistochemical analyses showed that this F_(ab) positively stained atherosclerotic aortic plaques in ApoE/ mice as well as those in patients with atherosclerosis. The F_(ab) also showed positive staining in placental decidua from patients with preeclampsia. It is suggested that the plaque 15,16-46 F_(ab) against oxLDL and cLDL might possibly be applicable for developing a diagnostic reagent for both human and rodent animal research to detect and characterize atherosclerotic disease progression in atherosclerotic lesions as well as exploring the pathogenesis of atherogenic diseases such as preeclampsia.
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