신 이식환자에서 C형 간염 치료 후 발생한 이식 신 기능 소실 1예

전현지,정병하,양철우 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.-

신 이식환자에서 C형 간염 치료 후 발생한 이식 신 기능 소실 1예

전현지,정병하,양철우 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1

Pegylated interferon 치료가 C형 간염환자의 치료에 사용된 이후 획기적인 환자 생존율의 향상을 보였다. 그러나 신 이식 환자의 경우 interferon으로 인한 면역 반응으로 인하여 급성 거부 반응을 유발할 수 있어, 사용에 주의가 필요하다. 51세 여환으로 신 이식 이후 C형 간염 바이러스의 재활성화로 인하여 pegylated interferon 치료 시행 후 발생한 거부 반응으로 인한 이식 간 기능 소실이 발생한 한 예를 보고하는 바이다. 2007 년 중국에서 신이식 받은 후 2년 경과할 당시까지 한 차례 급성 거부 반응이 발생했으나, 스테로이드 충격 요법에 반응하였고, 이후 정상 신기능 유지되는 중이었다. 2009년 2월 신기능의 급격한 저하로 본원 방문하여 시행한 검사에서 Serum creatinine (Scr) 2.04 mg/dL이고, 조직 검사에서 급성 거부 반응 진단되어 스테로이드 충격 요법 시행 후 신 기능은 정상으로 회복되었다. 입원시 AST/ALT 지속 적으로 상승있었고 HCV 항체 검사, HCV RNA는 2.53×103 copies /mL이었으나, 급성 거부 반응 치료 중임을 고려하여 항 바이러스제 치료 없이 경과 관찰하였다. 외래에서 경과 관찰 중 간 기능 더욱 악화되고, HCV RNA copy도 5.07×10 5 copies/mL로 지속 증가되었다. Ribavirin 400 mg 및 pegylated interferon 90 μg으로 치료를 시작한 후, 신 기능 정상으로 유지되어, Ribavirin 600 mg 및 pegylated interferon 135 μg으로 증량하였다. 3개월 뒤 외래에서 시행한 Scr 이 5.11 mg/dL로 급격히 증가하고 신 조직 검사에서 급성 거부 반응 (ACR IB) 진단되어 스테로이드 충격 요법 및 티모글로불린 치료 시행 후, Scr 2.21 mg/dL로 감소되었고, 항 바이러스 치료는 중단하였다. 외래 추적 중 7 개월 뒤 Scr 4.27 mg/dL로 다시 상승되어, 항거부 반응 치료 진행하였으나, 반응 보이지 않고 점차 신기능 감소되어 현재 혈액 투석 중이다.

밀집된 금속 나노 입자 레이어의 광학 특성

전현지,최진일,Jeon, Hyunji,Choi, Jinnil 한국재료학회 2020 한국재료학회지 Vol.30 No.12

Irradiation of the metal nanoparticles causes local plasmon resonance in a specific wavelength band, which can improve the absorption and scattering properties of a structure. Since noble metal nanoparticles have better resonance effects than those of other metals, it is easy to identify plasmonic reactions and this is advantageous to find the optical tendency. Compared to having a particle gap or randomly arranged particle structures, densely and evenly packed structures can exhibit more uniform optical properties. Using the uniform properties, the structure can be applied to optical filtering applications. Therefore, in this paper, validation tests about metal nanoparticles and thin film structures are conducted for more accurate analysis. The optical properties of monolayer and bilayer noble metal nanoparticle structures with different diameters, packed in a uniform array, are investigated and their optical trends are analyzed. In addition, a thin film structure under identical conditions as metal nanoparticle structure is evaluated to confirm the improved optical characteristics.

Kidney Transplantation in a Patient with End Stage Renal Disease after Complete Remission of Acute Promyelocytic Leukemia

전현지,Su Jeong Kim,In O Sun,정병하,김지일,문인성,민우성,양철우 대한의학회 2012 Journal of Korean medical science Vol.27 No.7

In general, a 2-yr disease-free duration is recommended before kidney transplantation (KT)in end-stage renal disease (ESRD) patients who also have acute leukemia. However, the optimal disease-free interval has not been specified for all subtypes of acute leukemia. Among these subtypes, acute promyelocytic leukemia (APL) shows a favorable prognosis and low relapse rate compared to other types of leukemia. We here report KT after complete remission (CR) of APL in an ESRD patient. Irreversible kidney injury developed in a 23-yr-old man with APL. First, we induced CR and subsequently performed KT 7 months after the achievement of CR. The patient’s clinical course after KT was favorable, without allograft rejection or relapse of APL up to1 yr after KT. On the basis of our clinical experience, it is suggested that a long wait may not be necessary before KT in patients with ESRD and APL.

자극음의 음향적 특성과 청각 뇌간에서의 전기생리학적 반응의 상관성

전현지,한우재,Chun, Hyungi,Han, Woojae 한국음향학회 2016 韓國音響學會誌 Vol.35 No.1

It is widely acknowledged that the human auditory system is organized tonotopically and people generally listen to sounds as a function of frequency distribution through the auditory system. However, it is still unclear how acoustic features of speech sounds are indicated to the human brain in terms of speech perception. Thus, the purpose of this study is to investigate whether two sounds with similar high-frequency characteristics in the acoustic analysis show similar results at the level of auditory brainstem. Thirty three young adults with normal hearing participated in the study. As stimuli, two Korean monosyllables (i.e., /ja/ and /cha/) and four frequencies of toneburst (i.e., 500, 1000, 2000, and 4000 Hz) were used to elicit the auditory brainstem response (ABR). Measures of monosyllable and toneburst were highly replicable and the wave V of waveform was detectable in all subjects. In the results of Pearson correlation analysis, the /ja/ syllable had a high correlation with 4000 Hz of toneburst which means that its acoustic characteristics (i.e., 3671~5384 Hz) showed the same results in the brainstem. However, the /cha/ syllable had a high correlation with 1000 and 2000 Hz of toneburst although it has acoustical distribution of 3362~5412 Hz. We concluded that there was disagreement between acoustic features and physiology outcomes at the auditory brainstem level. This finding suggests that an acoustical-perceptual mapping study is needed to scrutinize human speech perception. 청각기관의 음조체계로 인해 사람들은 일반적으로 주파수 분포에 따라 소리를 듣는다. 그러나 어음인지 측면에서 어음의 음향적 특성이 사람의 뇌에서 어떻게 인식되는지는 여전히 명확하지 않다. 따라서 본 연구에서는 유사한 고주파수 음향적 특성을 갖는 두 개의 어음이 청각 뇌간에서 전기생리학적으로 어떻게 발현되는 지 확인하고자 하였다. 정상 청력을 지닌 20대 성인 33명이 실험에 참여하였다. 자극음으로 두 개의 한국어 단음절 /자/와 /차/, 4개의 주파수로 구성된 톤버스트음(500, 1000, 2000, 4000 Hz)을 사용하여 청성뇌간반응을 얻었다. 연구 결과, 단음절과 톤버스트음 모두 높은 재현성을 보였고, 파형 V는 모든 피검자에게서 잘 발현되었다. 피어슨 상관관계 분석 결과, 3671 ~ 5384 Hz 대역에서 에너지 분포를 갖는 /자/ 음절은 4000 Hz의 톤버스트음과 높은 상관관계를 나타냈다. 그러나 /차/ 음절은 1000 Hz와 2000 Hz의 톤버스트음과 높은 상관성을 보여, 3362~5412 Hz의 음향적 특성과 청각 뇌간에서 생리학적 반응은 일치하지 않았다. 이러한 결과를 바탕으로 사람의 어음인지과정을 면밀히 조사하기 위해 음향-청지각적 매핑후속 연구가 필요하겠다.

인지수준에 따른 노인의 여가참여와 대인관계가 생활만족도에 미치는 영향

전현지,오명화,정현애 한국장애인재활협회 부설 재활연구소 2019 재활복지 Vol.23 No.1

This study was intended to investigate the effects of leisure participation and personal relations of seniors according to perception level on their life satisfaction. The results of conducting leisure participation, personal relation, and life satisfaction questionnaire on seniors aged 65 or older in Gwangju, Jeollanam-do according to perception level using MMSE-K are as follows. First, according to the result of comparing leisure participation, personal relation, and life satisfaction of seniors according to perception level, the total point and subdomains of leisure participation, personal relation, and life satisfaction showed a significant difference(p<.05). Secondly, according to the result of investigating a correlation between leisure participation, personal relation, and life satisfaction of research subjects, leisure participation, personal relation, and life satisfaction showed a positive correlation(p<.05). Thirdly, according to the result of investigating the effects of perception level, leisure participation, and personal relation on life satisfaction of research subjects, it was identified that they make effect on life satisfaction in the order of perception level, personal relation, and leisure participation. It is considered that it is necessary to develop an occupational therapy program that can improve various leisure activities and personal relation to maintain social participation and to improve life satisfaction of seniors with declined cognitive function, and to support performance enhancement of related activities. 본 연구는 인지수준에 따른 노인의 여가참여와 대인관계가 생활만족도에 미치는 영향과 이들의 상관관계를 알아보기 위해 실시되었다. 광주·전남에 거주하고 있는 65세 이상 노인을 대상으로 MMSE-K를 이용하여 인지수준에 따라 대상자를 구분하여 여가참여, 대인관계, 생활만족도 설문지를 실시한 결과 다음과 같았다. 첫째, 인지수준에 따라 노인의 여가참여, 대인관계, 생활만족도를 비교 한 결과 여가참여, 대인관계, 생활만족도의 총점과 하위영역 모두에서 유의한 차이를 보였다(p<.05). 둘째, 대상자의 여가참여와 대인관계, 생활만족도간의 상관관계를 본 결과 여가참여, 대인관계, 생활만족도 모두에서 양의 상관관계를 보였다(p<.05). 셋째, 대상자의 인지수준, 여가참여, 대인관계가 생활만족도에 미치는 영향을 알아본 결과 인지수준, 대인관계, 여가참여 순으로 생활만족도에 유의한 영향을 미치는 것으로 나타났다. 이상의 결과를 통해 인지기능저하 노인의 사회참여 유지와 생활만족도 향상을 위해 다양한 여가활동과 대인관계를 향상시킬 수 있는 작업치료 중재 프로그램을 개발하고, 관련 활동의 수행증진을 위한 지지가 필요할 것으로 생각된다.

Kaolinite 계열의 첨가제와 알칼리염의 반응 특성

전현지,최유진,선도원,한근희,배달희,이영우,Jun, HyunJi,Choi, Yujin,Shun, Dowon,Han, Keun-Hee,Bae, Dal-Hee,Rhee, Young-Woo 한국청정기술학회 2020 청정기술 Vol.26 No.3

When the waste solid fuel (SRF, Bio-SRF) is burnt in a boiler, a problem occurs in the combustion process involving the alkali components (Na, K) contained in large amounts in the fuel. The alkaline component has a low melting point, which usually forms low melting point salt in the temperature of the furnace, with the resulting low melting point salts attaching to the heat pipe to form a clinker. Various additives are used to suppress clinker generation, and the additive based on the kaolinite has alkali-aluminum-silica to inhibit the clinker. In this study, the reactivity of the additives based on the kaolinite was compared. The additives utilized were R-kaolinite, B-kaolinite, and A-kaolinite. Also silica and MgO were sourced as the comparison group. The experimental group was employed as a laboratory-scale batch horizontal reactor. The additive and alkaline salts were reacted at a weight ratio of 1 : 1, and the reaction temperature was performed at 900 ℃ for 10 hours. The first measurement of HCl occurring during the experiment was performed 30 minutes after the detection tube was used, and the process was repeated every hour after the experiment. After the reaction, solid residues were photographed for characterization analysis by means of an optical microscope. The reaction characteristics of the kaolinite were confirmed based on the analysis results. 폐기물고형연료(SRF, Bio-SRF)가 보일러에서 연소 될 때, 연료에 다량 함유되어있는 알칼리 성분(Na, K) 들이 연소과정에서 문제를 발생시킨다. 알칼리 성분은 낮은 melting point를 가지고 있어 통상 연소로 온도 내에서 저융점 염을 형성하고, 생성된 저융점 염들은 전열관에 달라붙어 클링커를 형성한다. 클링커생성을 억제하기 위해 다양한 첨가제가 사용되고 있으며, 고령석 기반의 첨가제는 알칼리-알루미늄-실리카가 형성되어 클링커를 억제한다. 본 연구에서는 고령석을 기반으로 하는 첨가제의 반응성을 비교 하였다. 사용된 첨가제는 R-kaolinite, B-kaolinite, A-kaolinite를 사용하였고 비교군 으로 silica와 MgO를 사용하였다. 실험은 실험실 규모의 회분식 수평형 반응기를 사용하였다. 첨가제와 알칼리염은 중량비 1:1로 반응토록 하였으며 반응 온도는 900 ℃에서 10시간 수행하였다. 실험 중 발생한 HCl은 검지관을 사용하여 30분 후 첫 측정을 하고 이후 1시간마다 반복하여 측정하였다. 반응 후 고체 잔여물은 특성 분석을 위하여 광학현미경으로 촬영하였다. 분석결과를 토대로 고령석의 반응특성을 확인하였다.

Error Patterns Analysis of Hearing Aid and Cochlear ImplantUsers as a Function of Noise

전현지,마선미,한우재,전영명 대한청각학회 2015 Journal of Audiology & Otology Vol.19 No.3

Background and Objectives: Not all impaired listeners may have the same speech perception ability although they will have similar pure-tone threshold and configuration. For this reason, the present study analyzes error patterns in the hearing-impaired compared to normal hearing (NH) listeners as a function of signal-to-noise ratio (SNR). Subjects and Methods: Forty-four adults participated: 10 listeners with NH, 20 hearing aids (HA) users and 14 cochlear implants (CI) users. The Korean standardized monosyllables were presented as the stimuli in quiet and three different SNRs. Total error patterns were classified into types of substitution, omission, addition, fail, and no response, using stacked bar plots. Results: Total error percent for the three groups significantly increased as the SNRs decreased. For error pattern analysis, the NH group showed substitution errors dominantly regardless of the SNRs compared to the other groups. Both the HA and CI groups had substitution errors that declined, while no response errors appeared as the SNRs increased. The CI group was characterized by lower substitution and higher fail errors than did the HA group. Substitutions of initial and final phonemes in the HA and CI groups were limited by place of articulation errors. However, the HA group had missed consonant place cues, such as formant transitions and stop consonant bursts, whereas the CI group usually had limited confusions of nasal consonants with low frequency characteristics. Interestingly, all three groups showed /k/ addition in the final phoneme, a trend that magnified as noise increased. Conclusions: The HA and CI groups had their unique error patterns even though the aided thresholds of the two groups were similar. We expect that the results of this study will focus on high error patterns in auditory training of hearing-impaired listeners, resulting in reducing those errors and improving their speech perception ability.

리튬이온 배터리 전극의 성능 향상을 위한 슬러리 제조 공정 최적화

전현지,최병준,류정헌,김정경,홍창성,우상길,유지상,이제남 한국공업화학회 2023 한국공업화학회 연구논문 초록집 Vol.2023 No.0

온양민속박물관 소장 나전칠빗접 과학적 재질 분석 및 보존처리

전현지,김수철,강민지,박정혜 한국가구학회 2022 한국가구학회지 Vol.33 No.4

Onyang Folk Museum owns a Lacquered comba box with Mother-of-Pearl - bitjeop. The bottom and sides of the drawer were damaged, and the black lacquer varnished on the lid disappeared. Therefore, scientific analysis and conservation treatment were progressed. We tried to establish basic data to understand the materials and preservation processes of modern wooden lacquered craftworks. As a result of the scientific analysis, the Lacquered comba box with Mother-of-Pearl - bitjeop. is made of Hard Pine and the lacquered surface is made up various overlapped layers from the foundation layer to the coating layer. The brown layer in the middle of several layers has silicon, aluminum, and iron, indicating that it is mixed with soil and lacquer. The coating layer was identified as cashew because it includes Cardanol polymer. The metal decoration was confirmed to be brass. We pasted the wood that fell from the drawer with animal glue and wood powder. The mother-of-pearl was cut out along the remanent pattern, attached with animal glue, and surroundings of the pattern were filled with lacquer. Wooden lacquered craftworks are sensitive to temperature and humidity, so it is difficult to dry the coating for a long time in a drying place. Because of this, we only proceeded the degree of restoring shape of the Mother-of-Pearl that completely disappeared. It allows to show the original shape of the artifact with trace of time.