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소음인(少陰人) 소합향원(蘇合香元)의 효능(效能)에 관(關)한 실험적(實驗的) 연구(硏究)
전진상,Jeon, Jin Sang 사상체질의학회 1993 사상체질의학회지 Vol.5 No.1
In order to investigate experimentally the clinical effects of Soeuminsohaphyangwon that was prescribed to cure the Wisunanrihanbyung of Soeum-In, the author experimented various activities of mixed extract from the Soeuminsohaphyangwon by the method prescribed in the experimental part. The results of the studies were summerized as follows : 1. Suppressive action was not shown on the convulsion induced by strychnine but significant effect was noted on the convulsion induced by picrotoxin and caffeine. 2. In acetic acid method experiment analgesic effect was noted. 3. A prolongation of anesthetic time by Pentobarbital sodium and antipyretic effect was observed. 4. Relaxing action was noted on the ileums of mice, also same effect was recognized on contraction of the ileums due to acetylcholine, barium chloride and histamine 2 HCl. 5. The expansion of blood vessels by relaxation of smooth muscle and fall of blood pressure were noted. According to the above results, effects based on oriental medical references were approximate to the actual experimental results.
소음인(少陰人) 승양익기부자탕(升陽益氣附子湯)과 관계부자리중탕(官桂附子理中湯)이 양허증(陽虛證)에 미치는 영향(影響)에 관(關)한 실험적(實驗的) 연구(硏究)
전진상,Jeon, Jin Sang 사상체질의학회 1989 사상체질의학회지 Vol.1 No.1
In order to investigate experimentally the effects of Sung-yangikgibujat'ang (SIT) and Kwangyebujalijungt'ang (KBT) on Yang-insufficient syndrome (陽虛證) induced by Hydrocortisone acetate (H.A.) in experimental animals (Mice and Rat), the author experimented various activities. Delayed type hypersensitivity (DTH), Rosette forming cells (RFC), hemagglutinin (HA) titers, Hemolysin (HL) titers, Body weight, Whole blood viscosity, Plasma Viscosity, Hematocrit, RBC, Albumin, Total protein, Triglyceride, cholesterol and Glucose were measured. The results summerized as follows; 1. In DTH and RFC all the experimental groups were increased significantly in comparison to the H.A.-treated group. 2. In HA titers SIT_treated group were increased significantly and KBT-treated group showed increasing tendancy, but showed no significance. 3. In HL titers all the experimental groups showed increasing tendancy, but showed no significance. 4. In body weight all the experimental groups showed increasing tendancy, but showed no significance. 5. In whole blood viscosity all the experimental groups were decreased significantly in comparison to the H.A.-treated group. 5. In whole blood viscosity all the experimental groups were decreased significantly in comparison to the H.A.-treated group. 6. In plasma viscosity KBT-treated group were decreased significantly and SIT-treated group showed decreasing tendancy, but showed no significance. 7. In Hematocrit SIT-treated group were decreased significantly and KBT-treated group showed decreasing tendancy, but showed no significance. 8. In RBC, albumin and cholesterol all the experimental groups were decreased significantly in comparison to the H.A.-treated group. 9. In total protein and triglyceride KBT-treated group were decreased significantly and SIT-treated group showed decreasing tendancy, but showed no significance. 10. In Glucose SIT-treated group were decreased significantly and KBT-treated group showed decreasing tendancy, but showed no significance. From above findings, it has been demonstrated that Sungyangikgibujat'ang and Kwangyebujalijungt'ang seem to produce the effectiveness on the recovery from depression of the cell-mediated immune response, blood circulation and energy metabolic rate, induced by Hydrocortisone acetate, and in the humoral immune response Sungyangikgibujat'ang have the effectiveness on the recovery, and in cellular component of blood Sungyangikgibujat'ang was more effective than Kwangyebujalijungt' ang, and in plasma of blood Kwangyebujalijungt'ang was more effective than Sungyangikgibujat'ang. Therefore it is suggested that Sungyangikgibujat'ang and Kwangyebujalijungt'ang have the effectiveness on the recovery from Yang-insufficient syndrome more or less.
생약 복합제제의 약효 연구(제25보) : 소음인소합원이 항경련, 진통, 해열, 진정, 적출장관, 혈관 및 혈압에 미치는 영향
전진상(Jin Sang Jun),김남재(Nam Jae Kim),원도희(Do Hee Won),송일병(Il Byung Song),홍남두(Nam Doo Hong) 한국생약학회 1985 생약학회지 Vol.16 No.3
In order to investigate experimentally the clinical effects of Soeuminsohapwon that was prescribed to cure cerebral hemorrhage, palpitation etc, the author tested various activities of extract from the Soeuminsohapwhangwon by the method prescribed in the experimental part. The results of the studies were summarized as follows: Suppressive action was not shown on the convulsion induced by strychnine, but significant effect was noted on the convulsion induced by picrotoxin and caffeine. In acetic acid method, analgesic effect was noted. A prolongation of anesthetic time by pentobarbital sodium and antipyretic effect was observed. Relaxing action was noted on the ileum of mice, also same effect was recognized on contraction of the ileum due to acetylcholine, barium chloride and histamine. The expansion of blood vessels by relaxation of smooth muscle and hypotensive action were noted. According to the above results, effects based on oriental medical references were approximate to the actual experimental results.
생약복합제제의 약효 연구(제24보) : 소음인소합원이 항경련, 진통, 해열, 진정, 적출장관, 혈관 및 혈압에 미치는 영향
홍남두(Nam Doo Hong),송일병(Il Byung Song),김남재(Nam Jae Kim),전진상(Jin Sang Jun),원도희(Do Hee Won) 한국생약학회 1985 생약학회지 Vol.16 No.1
소음인소합원은 이제마의동의수세보윈에 처음으로 수록된 방제로 소합향원의 변방으로서 청열해표, 개규안신, 순기화담등의 효능을 갖는 생약복합제제이다. 또한 이 방제는 백출(Atractylodis Rhizoma alba)를 비롯하여 14종의 생약으로 구성되어 있다. 따라서, 연자등은 생약복합제제의 약효연구 일환으로 소음인 소합원의 임상적 효능과 한방 문헌적 효능을 기초약물학적 측면에서 동물실험 성적과의 관련성을 검토하고자하여 실험한 결과 다음과 같은 성적을 얻었다. 1. Strychnine에 의한 항경련효과는 인정할 수 없었으나, Caffeine과 Picrotoxin에 의한 경련에 대하여서는 항경련효과가 인정되었다. 2. 중추신경의 진통, 해열 및 진정효과를 나타내었다. 3. 생쥐적출회장관의 자동운동을 현저하게 억제시켰으며, 생쥐 및 모르모트 적출회장관에 대하여 장평활근에 대한 직접적인 이완효과를 나타내었다. 4. 혈관평활근 이완에 의한 혈관확장작용과 혈압강하효과를 나타내어있다.