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류마티스 관절염 환자의 활막 세포와 T세포의 유착에서 ICAM-1의 역할
전재범 ( Jae Bum Jun ),김동욱 ( Dong Yook Kim ),김태환 ( Tae Hwan Kim ),김승영 ( Seung Young Kim ),김평남 ( Pyoung Nam Kim ),정성수 ( Sung Soo Jung ),이인홍 ( In Hong Lee ),배상철 ( Sang Cheol Bae ),유대현 ( Dae Hyun Yoo ),김순길 대한류마티스학회 1995 대한류마티스학회지 Vol.2 No.2
연구배경: 류마티스 관절염에서 유착분자는 활막염이 발생하고 지속되는데 중요한 역할을 한다. 활막에 침윤된 T세포와 활막세포의 상호작용에서 ICAM-l의 역할을 알아보고자 하였다. 방법: 류마티스 관절염 환자에서 슬관절 전치환 술동안에 활막조직을 얻은 후 ICAM-l에 대한 단클론항체를 이용하여 면역조직화학법으로 ICAM-l의 발현을 관찰하였고, 억제실험을 통해 ICAM-1이 활막세포와 T세포간의 상호작용에 미치는 영향을 조사 하였다. 결과: 1) ICAM-1은 활막의 거의 모든 구성조직에서 발현되었으며, IL-1으로 처리한 후 발현이 증가되었다. 2) IL-1으로 처리한 군에서 유착지수가 대조군에 비해 의미있게 증가하였고, 항ICAM-1항체로 ICAM-1의 기능을 차단한 군에서 활막세포와 T세포의 유착이 의미있게 감소하였다. 결론: 활막세포와 T세포간의 상호작용이 류마티스 관절염 환자의 활막조직에서 일어나고 있으며, 이들 세포간의 유착에 ICAM-1 경로가 중요한 역할을 할 것이다. Objective: It has previously been shown that cellular interaction between infiltrating mononuclear cells and synoviocyte are important in the initiation and perpetuation of autoimmune processes in the synovial tissue of patients with rheuamtoid arthritis. Thus, we have investigated the molecular basis of T cell-synovial cell interaction in the cultured synoviocytes from patients with rheumatoid arthritis. Methods: Using an immunohistochemical staining technique and inhibition study with monoclonal antibody, we studied the expression and the function of intercellular adhesion molecule l (ICAM-l) in T cell-synovial cell interaction in the cultured synoviocytes. Results: Expression of ICAM-l was diffusely observed in most components of rheumatoid synovium and readily up-regulated by IL-1. T cell-synovial cell interaction was inhibited by monoclonal antibody aganinst ICAM-1. Conclusion: These results showed that ICAM-l was involed in the cellular interaction between T lymphocytes and synovial cells in patients with rheumatoid arthritis.
위험-수익 원칙에 기반한 도시재생사업의 재무적 전략 : 미국과 일본의 사례를 중심으로
전재범(Jun, Jae-Bum) 한국부동산정책학회 2020 不動産政策硏究 Vol.21 No.1
Recently, the need for urban regeneration projects has emerged in many cities in Korea due to the decline of urban functions, and related research has been on the rise. But, research relevant to how to finance those projects is very rare. As urban regeneration projects are large in scale and involve many interested parties, it is important to raise capital properly considering the level of risk for successful project. In light of this, a successful urban regeneration project requires discussion of various forms of development financing techniques, along with the way of finance based on the risk-return principle that project participants seek adequate returns to meet the level of risk, based on their financial characteristics, revenue structure and full understanding of the project s capital procurement. Therefore, the purpose of this paper is to analyze examples of financing techniques such as tranche-financing based on the risk-reward principle with the financial characteristics of the project and the revenue structure and mezzanine-financing deriven from the urban renewal fund, thereby considering the advanced techniques and financial strategies of development financing for urban regeneration projects and obtaining relevant implications.
지급보증이 존재하는 부동산 PF 사업에서 건설사 우발채무의 발생시기 추정
전재범(Jun, Jae-Bum) 대한건축학회 2014 대한건축학회논문집 Vol.30 No.12
PF scheme has been widely used for its efficiency in dealing with risks and maximizing returns on investment in real estate development. However, since the weight of capital financed by Special Purpose Vehicle to buy land and support early stage of project is relatively low compared to total project cost and most of construction cost is financed from sales income in Korea, success rate of PF is radically low under high level of market uncertainty. For this reason, debt investors in real estate PF have tries to take loan guarantee agreement, which imposes contingent liability on construction firm under uncertain economy condition, from construction firm. In light of this, it seems important to take an effort to estimate occurring time of construction firm"s contingent liability in that information taken from this trial can help joining entities in a project including construction firm prepare impending risks but reality is related research just has been focused in understanding and scrutinizing mechanism or quantitative amount of construction firm"s contingent liability. Therefore, this paper is to suggest theoretical framework to evaluate occurring time of construction firm"s contingent liability based on relevant financial and economic theories in real estate PF with loan guarantee.
류마티스 관절염 환자에서 Bucillamine이 모발 미세원소 농도에 미치는 영향
전재범 ( Jae Bum Jun ),김동욱 ( Dong Yook Kim ),김태환 ( Tae Hwan Kim ),김승영 ( Seung Young Kim ),김평남 ( Pyoung Nam Kim ),정성수 ( Sung Soo Jung ),이인홍 ( In Hong Lee ),배상철 ( Sang Cheol Bae ),유대현 ( Dae Hyun Yoo ),김순길 대한류마티스학회 1995 대한류마티스학회지 Vol.2 No.2
1) 목적: Bucillamine은 최근 개발된 항류마티스제로, D-penicillamine과 구조가 유사하다. 류마티스 관절염 환자에서 D-penicillamine치료후 미세원소 농도의 변화에 대한 다양한 보고가 있으나 Bucillamaine의 영향에 대한 보고는 없다. 류마티스 관절염의 환자에서 Bucillamine치료후 모발의 미세원소 농도의 변화를 알아보고자 본 연구를 시행 하였다. 2) 방법: 류마티스 관절염 환자에서 Bucillamine 치료 전후에 모발올 채취하여 유도결합 플라즈마 원자방출분광법으로 미세원소 농도를 측정하여 비교하였다. 또한 3개월 이상 장기간 Bucillamine치료를 받은 환자의 모발을 근위부와 원위부로 분절하여 미세원소 농도를 비교하여 농도의 변화를 간접적으로도 분석하였다. 3) 결과: Bucillamine치료후 구리의 농도는 의미있게 증가하였으나 아연은 의미있는 변화를 보이지 않았다. 또한 최소 3개월 이상 Bucillamine치료를 받은 환자의 모발에서 근위부와 원위부를 비교하여 보았으나 구리와 아연 모두 의미있는 변화를 보이지 않았다. 4) 결론: 비록 Bucillamine치료후 구리의 농도가 의미있게 증가하였으나 류마티스 판절염 환자의 모발에서 미세원소 농도에 Bucillamine이 미치는 영향에 대해서는 어떠한 결론도 내릴 수 없었다. 향후 좀 더 많은 예에서 D-penicillamine과의 비교연 구가 필요할 것으로 사료된다. Objectives: We investigated the changes of trace element levels in hair of patients with rheumatoid arthritis after bucillamine treatment. Methods: We performed inductively coupled plasma atomic emission spectrometry in determination of trace element levels in hair of patients with rheumatoid arthritis. Results: The results were as follows: 1) There was a significant increase of copper concentration, but no change in zinc level after bucillamine treatment. 2) There were no significant changes in copper and zinc concentrations between the proximal and distal portions of hair after long-term bucillamine treatment. Conclusions: Our results showed the significant increase of copper level and no significant change of zinc level in hair after bucillamine treatment, but, although statistically not significant, copper and zinc levels were decreased on experiment with divided hair. So, our findings do not permit any conclusion on the influence of bucillamine on trace element levels in hair. Further studies in large samples and comparison with the effect of D-penicillamine will be necessary to clarify the association of trace element levels in hair of rheumatoid arthritis patients and bucillamine treatment.
전재범 ( Jae-bum Jun ) 대한내과학회 2019 대한내과학회지 Vol.94 No.1
“의료 윤리”가 의사들이 이수해야 할 필수 과목이 된 시대를 살고 있다. 본 지면에서는 우선 대한내과학회에 윤리위원회가 설치된 배경과 그 과정을 정리하고, 내과 의사 윤리 선언의 제정과 내용에 대하여 살펴본 후, 내과 의사가 되고자하는 내과 전공의들에 대한 윤리 교육의 현재와 앞으로의 방향에 대하여 기술해보고자 한다.
류마티스 관절염 환자에서 혈청 creatine kinase의 활성도
전재범 ( Jae Bum Jun ),황관표 ( Kwan Pyo Hong ),김태환 ( Tae Hwan Kim ),정성수 ( Sung Soo Jung ),이인홍 ( In Hong Lee ),배상철 ( Sang Cheol Bae ),유대현 ( Dae Hyun Yoo ),주경빈 ( Kyung Bin Joo ),김성윤 ( Seong Yoon Kim ) 대한류마티스학회 1997 대한류마티스학회지 Vol.4 No.1
Objective: Our objective was (1) to determine if serum creatine kinase (CK) activity is reduced in rheumatoid arthritis (RA) compared with that of noninflammatory rheumatic diseases, (2) to examine the recently described association of low CK activity and disease variables in our RA population, and (3) to examine the influence of steroid on serum CK activity in patients with RA. Methods: Cross sectional and longitudinal retrospective analyses of clinical and biochemical data of consecutive patients with RA and noninflammatory arthropathies. In all subjects we evaulated age, sex, weight, and, only for patients with RA, history of use of corticosteroids and Ritchie index. C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), hemoglobin, and platelet count were simultaneously determined as variables of disease activity. CK activity was determined by automated biochemical analyzer (Hitachi 747, Japan). Results: Serum CK activity was significantly reduced in RA (mean±SD: 45.7±24.2 IU/L) compared to controls (81.3±33.9 IU/L) (p<0.001). Ritchie index, CRP, and platelet count correlated inversely with CK values (correlation coefficient: -0.31, p<0.01; -0.45, p<0.001; -0.42, p<0.001, respectively). Patients taking steroids had lower CK activity than those without steroid, but not statistically significant. Conclusion: Serum CK activity is significantly reduced in RA. Serum CK activity correlates well with various indices of disease activity for rheumatoid arthritis. So, Inflammatory activity seems to play the major role in this phenomenon. Multiple regression analysis showed that CRP, but not steroids, was the major independent factor influencing CK activity.