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장인석,전병탁,Eun Ae Jeong,김은진,강다원,이종실,정백근,김진현,Bong Hoi Choi,이정은,김종우,최준영,노구섭 대한약리학회 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.3
Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are the major histological types of non-small cell lung carcinoma (NSCLC). Although both SCCs and ACs have been characterized histologically and clinically, the precise mechanisms underlying their migration and invasion are not yet known. Here, we address the involvement in NSCLC of the p21-associated kinase1 (Pak1)/LIM kinase1 (LIMK1)/cofilin pathway, which recently has been reported to play a critical role in tumor migration and invasion. The Pak1/LIMK1/cofilin pathway was evaluated in tumors from SCC (n=35) and AC (n=35) patients and in SCC- and AC-type cell lines by western blotting, immunohistochemistry, and in vitro migration and invasion assays. The levels of phosphorylated Pak1, LIMK1, and cofilin in lung tumor tissues from SCC patients were increased as compared to normal tissues. In addition, immunohistochemistry showed greater expression of phosphorylated cofilin in SCC tissues. Expression of phosphorylated Pak1 and LIMK1 proteins was also significantly higher in SCC-type cells than in AC-type cells. Moreover, migration and invasion assays revealed that a higher percentage of SCC type cells exhibited migration and invasion compared to AC type cells. Migration was also decreased in LIMK1 knockdown SK-MES-1 cells. These findings suggest that the activation of the Pak1/LIMK1/ cofilin pathway could preferentially contribute to greater tumor migration and invasion in SCC, relative to that in AC.
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이진옥,전병탁,김영희,정태식,이동훈,김현준,강상수,조경제,최완성,노구섭 대한해부학회 2009 Anatomy & Cell Biology Vol.42 No.3
Adiponectin is an adipocyte-derived protein with anti-diabetic and anti-angiogenesis properties that improves both glucose metabolism and insulin resistance via the adenosine monophosphate-activated protein kinase (AMPK) cascade. Diabetic cognitive deficits are correlated with dysregulation of energy metabolism in the hippocampus. In the present study, we investigated the expression of adiponectin-mediated AMPK cascade proteins in the hippocampus of streptozotocin (STZ)-induced diabetic mice. Diabetes was induced by STZ (55 mg/kg) injection intraperitoneally. Twenty-four weeks after induction of diabetes, mice were sacrificed. Results showed that decreased serum adiponectin levels and increased expression of hippocampal adiponectin receptor 1 (AdipoR1) was expressed in diabetic mice. Phosphorylated AMPK, acetyl CoA carboxylase (ACC), and eNOS expression levels were increased in the hippocampus of diabetic mice. The immunoreactivity of glucose transporter 1 in the endothelium of hippocampal blood vessels was also increased. These results indicate that adiponectin-mediated AMPK cascade activation may play a role in catabolic process that is involved in diabetic neurodegeneration.
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김석,노구섭,정태식,김화진,허록원,이진옥,이정은,전병탁,김원호,함종렬 대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.4
Exendin-4 (Ex-4), a glucagon-like peptide-1 receptor (GLP-1R) agonist, has been known to reversehepatic steatosis in ob/ob mice. Although many studies have evaluated molecular targets of Ex-4, itsmechanism of action on hepatic steatosis and fibrosis has not fully been determined. In the liver,glucose transporter 4 (GLUT4) is mainly expressed in hepatocytes, endothelial cells and hepatic stellatecells (HSCs). In the present study, the effects of Ex-4 on GLUT4 expression were determined in theliver of ob/ob mice. Ob/ob mice were treated with Ex-4 for 10 weeks. Serum metabolic parameters,hepatic triglyceride levels, and liver tissues were evaluated for hepatic steatosis. The weights of thewhole body and liver in ob/ob mice were reduced by long-term Ex-4 treatment. Serum metabolicparameters, hepatic steatosis, and hepatic fibrosis in ob/ob mice were reduced by Ex-4. Particularly,Ex-4 improved hepatic steatosis by enhancing GLUT4 via GLP-1R activation in ob/ob mice. Ex-4treatment also inhibited hepatic fibrosis by decreasing expression of connective tissue growth factorin HSCs of ob/ob mice. Our data suggest that GLP-1 agonists exert a protective effect on hepaticsteatosis and fibrosis in obesity and type 2 diabetes.
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