RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      검색결과 좁혀 보기

      • 좁혀본 항목

      • 좁혀본 항목 보기순서

        • 원문유무
        • 음성지원유무
          • 원문제공처
          • 등재정보
          • 학술지명
          • 주제분류
          • 발행연도
          • 작성언어
          • 저자

        오늘 본 자료

        • 오늘 본 자료가 없습니다.
        더보기
        • 무료
        • 기관 내 무료
        • 유료
        • KCI등재후보
        • KCI등재

          고관절 주위 골절 노인 환자에서 대퇴골두 연골의 변성

          장준동,유제현,이상수,심정원,김창영,권순억 대한정형외과학회 2006 대한정형외과학회지 Vol.41 No.3

          =목 적: 고관절 주위 골절이 있었던 노인 환자에서 대퇴골두의 관절 연골의 변성 정도를 육안적, 조직학적, 면역 조직 화학적 소견을 통해 평가해 보고자 하였다.대상 및 방법: 고관절 주위 골절로 양극성 반치환술을 시행 받은 65세 이상 환자 중 수상 전에 고관절부 동통없이 보행이 가능하고 술 전 단순 방사선 사진상 퇴행성 변화가 없었던 30예를 대상으로 하였고, 평균 나이는 79.7세(65-94)였다. 육안적 소견은 술 중 적출된 대퇴골두의 체중 부하부위 3구역(전상, 중상, 후상방) 및 비체중 부하부위 1구역(하방)에서 시행한 후, 총 4구역에서 연골하골을 포함한 관절 연골을 채취하여 Hematoxylin & Eosin 염색 및 Safranin O 염색을 시행하여 조직학적 변성정도를 분류하였고, II형 collagen 항체를 이용하여 면역 조직 화학염색을 시행하였다.결 과: Outerbridge 분류에 의한 육안적 소견은 grade I 이하가 82.5%였고, Mankin 등급에 의한 조직학적 소견과는 유의한 상관 관계를 보였다. Mankin 등급에 의한 조직학적 소견은 24예(80%)에서 경도의 변성을, 나머지 6예에서 중등도의 변성을 보였으며, 각 구역별 변성 정도는 모두 평균 5점 이하로 경도의 변성을 보였다. 체중 부하부위와 비체중 부하부위 간의 변성 정도에는 유의한 차이가 없었다. Hollander 등의 분류에 의한 면역 조직 화학염색상 결과는 grade I 이하가 28예(93.3%)로 대부분 정상 또는 경미한 변성을 보였다.

        • Omega-3 지방산의 항암성에 관한 연구

          張浚東,黃祐翊 고려대학교 의과대학 1993 고려대 의대 잡지 Vol.30 No.1

          This study was devised to observe the cytotoxic activty of omega-3 (n-3) fatty acids against human colon (HT-29) and rectum (HRT-18) cancer cells and normal monkey kidney cell (VERO 76) in vitro. α-linolenic acid and Cod liver oil containing 25% or 70% n-3 fatty acids were used for this experiment. Each cell line was incubated in medium containing several concentration of α-linolenic acid and Cod liver oil for 72 hours, and then the growth rate and dose-response of each cell were determined, and size distribution and morphological change of HRT-18 estimated. The experimental results obtained are summarized as follows, 1. The growth rates of HT-29, HRT-18 and VERO 76 were gradully inhibited in proportion to the concentration (below 40 ㎍/ml) of α-linolenic acid in culture medium, then the cell numbers of each cell line were significantly reduced compared with initial seeding cell number at above 50 ㎍/ml concentration of α-linolenic acid. 2. The growth rate of HT-29 was slightly reduced in medium containing 100 ㎍/ml of Cod liver oil contained 25% n-3 fatty acid, compared with control group, but the growth rates of HRT-18 and VERO 76 were similar to that of control group. 3. The cell number of HT-29 cultured in medium containing 100 ㎍/ml of Cod liver oil (contained 70% n-3 fatty acid) maintained the level of initial seeding cell number, but that of HRT-18 and VERO 76 were reduced to 59% and 30% compared with control group after incubation for 72 hours. 4. The cell size of HRT-18 incubated in culture medium containing α-linolenic acid(40 ㎍/ml) and Cod liver oil (200 ㎍/ml) was significantly reduced, compared with that of control group, also, the microscopic shape of HRT-18 was shrinked and distracted. In view of the result, it could be suggested that n-3 fatty acid have strong cytotoxic activity against human rectum and colon cancer cell line in vitro test.

        • KCI등재후보
        • 대퇴골 경부에 발생한 유골 골종의 관절경적 치료

          장준동,이원익,이응주,이병국 대한정형외과학회 2002 대한정형외과학회지 Vol.37 No.1

          Arthroscopic Treatment of an Osteoid Osteoma in the Femoral Neck - A Case Report - Jun-Dong Chang, M.D., Weon-Ik Lee, M.D., Eung-Joo Lee, M.D., and Byung-Kook Lee, M.D.

        • KCI등재

          Future Bearing Surfaces in Total Hip Arthroplasty

          장준동 대한정형외과학회 2014 Clinics in Orthopedic Surgery Vol.6 No.1

          One of the most important issues in the modern total hip arthroplasty (THA) is the bearing surface. Extensive research on bearing surfaces is being conducted to seek an ideal bearing surface for THA. The ideal bearing surface for THA should have superior wear characteristics and should be durable, bio-inert, cost-effective, and easy to implant. However, bearing surfaces that are currently being implemented do not completely fulfill these requirements, especially for young individuals for whom implant longevity is paramount. Even though various new bearing surfaces have been investigated, research is still ongoing, and only short-term results have been reported from clinical trials. Future bearing surfaces can be developed in the following ways: (1) change in design, (2) further improvement of polyethylene, (3) surface modification of the metal, (4) improvement in the ceramic, and (5) use of alternative, new materials. One way to reduce wear and impingement in THA is to make changes in its design by using a large femoral head, a monobloc metal shell with preassembled ceramic liner, dual mobility cups, a combination of different bearing surfaces, etc. Polyethylene has improved over time with the development of highly crosslinked polyethylene. Further improvements can be made by reinforcing it with vitamin E or multiwalled carbon nanotubes and by performing a surface modification with a biomembrane. Surface modifications with titanium nitride or titanium niobium nitride are implemented to try to improve the metal bearings. The advance to the fourth generation ceramics has shown relatively promising results, even in young patients. Nevertheless, further improvement is required to reduce fragility and squeaking. Alternative materials like diamond coatings on surfaces, carbon based composite materials, oxidized zirconium, silicon nitride, and sapphire are being sought. However, long-term studies are necessary to confirm the efficacy of these surfaces after enhancements have been made with regard to fixation technique and implant quality.

        • KCI등재
        • KCI등재

          Acute Delayed or Late Infection of Revision Total Hip Arthroplasty Treated with Debridement/Antibiotic-loaded Cement Beads and Retention of the Prosthesis

          장준동,김인성,이상수,유제현 대한고관절학회 2017 Hip and Pelvis Vol.29 No.1

          Purpose: The treatment of infected revision total hip arthroplasty (THA) is very challenging due to retained revision prosthesis, poor bone stock and soft tissue condition derived from previous revision surgeries, and comorbidities. The purpose of this study was to investigate the effectiveness and short-term outcomes of aggressive debridement and use of antibiotic-loaded cement beads with retention of the prosthesis for acute delayed or late infection of revision THAs. Materials and Methods: Ten consecutive patients with symptoms or signs of less than one-week evolution and well-fixed prostheses, were treated with this procedure and a postoperative course of organism-specific antibiotics for a minimum of 6 weeks. All hips presented with acute delayed or late infection of revision THAs. Patients with a mean age of 68.1 years (range, 59-78 years) underwent an average of 1.9 previous revision THAs (1-4) before the index surgery. The minimal follow-up was 2 years with a mean of 46.2 months (range, 24-64 months). Results: There were 8 cures (80.0%) and 2 failures with no mortality during the study period. The 2 failures involved the same and resistant bacteria implicated in the primary infection (methicillin-resistant Staphylococcus aureus and Prevotella oralis, respectively). The mean Harris hip score was 65.2 (range, 26-83) and the mean visual analogue scale was 2.6 (range, 1-4) at final follow-up. Conclusion: With a favorable success rate and no mortality, our procedure may be considered a safe and effective alternative for the treatment of acute delayed or late infection of revision THAs with well-fixed prostheses.

        맨 위로 스크롤 이동