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비만에서 adipose tissue 호르몬에 의한 metabolic signaling
장영훈 한국생명과학회 2023 생명과학회지 Vol.33 No.3
Healthy adipose tissue is critical for preventing obesity by maintaining metabolic homeostasis. Adipose tissue plays an important role in energy homeostasis through glucose and lipid metabolism. Depending on nutritional status, adipose tissue expands to store lipids or can be consumed by lipolysis. The role of adipose tissue as an endocrine organ is emerging, and many studies have reported that there are various adipose tissue hormones that communicate with other organs and tissues through metabolic signaling. For example, leptin, a representative peptide hormone secreted from adipose tissues (adipokine), circulates and targets the central nervous system of the brain for appetite regression. Furthermore, adipocytes secrete inflammatory cytokines to target immune cells in adipose tissues. Not surprisingly, adipocytes can secrete fatty acid-derived hormones (lipokine) that bind to their specific receptors for paracrine and endocrine action. To understand organ crosstalk by adipose tissue hormones, specific metabolic signaling in adipocytes and other communicating cells should be defined. The dysfunction of metabolic signaling in adipocytes occurs in unhealthy adipose tissue in overweight and obese conditions. Therapy targeting novel adipose metabolic signaling could potentially lead to the development of an effective anti-obesity drug. This review summarizes the latest updates on adipose tissue hormone and metabolic signaling in terms of obesity and metabolic diseases.
장영훈,민도식 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.10
Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidic acid. PLD is localized in most cellular organelles, where it is likely to play different roles in signal transduction. PLD1 is primarily localized in vesicular structures such as endosomes, lysosomes and autophagosomes. However, the factors defining its localization are less clear. In this study, we found that four hydrophobic residues present in the N-terminal HKD catalytic motif of PLD1, which is involved in intramolecular association, are responsible for vesicular localization. Site-directed mutagenesis of the residues dramatically disrupted vesicular localization of PLD1. Interestingly, the hydrophobic residues of PLD1are also involved in the interruption of its nuclear localization. Mutation of the residues increased the association of PLD1 with importin-β, which is known to mediate nuclear importation, and induced the localization of PLD1 from vesicles into the nucleus. Taken together, these data suggest that the ydrophobic amino acids involved in the interdomain association of PLD1 are required for vesicular localization and disturbance of its nuclear localization.
Association between Helicobacter pylori Infection and Eosinophilic Esophagitis
장영훈,신철민,이동호,윤혁,박영수,김나영 대한소화기학회 2023 대한소화기학회지 Vol.82 No.3
Background/Aims: This study examined the association between eosinophilic esophagitis (EoE) and Helicobacter pylori (H. pylori) infection. Methods: A single tertiary referral center case-control study was performed. EoE patients diagnosed at Seoul National University Bundang Hospital from July 2003 to March 2022 were reviewed retrospectively. Forty-five EoE patients were included in the analysis. For each EoE patient, two age and sex-matched normal controls were selected randomly from an outpatient population who received upper gastrointestinal endoscopy. Results: Although 17 out of 90 (18.9%) controls had a H. pylori infection, only two out of 45 (4.4%) EoE patients showed evidence of a H. pylori infection. EoE was inversely associated with a H. pylori infection (odds ratio 0.20, 95% confidence interval 0.04–0.91, p=0.044). Conclusions: An inverse association was observed between H. pylori infection and EoE. Further prospective studies will be needed to validate the protective effects of H. pylori infection for EoE.
무현금 사회의 디지털 접근성과 시스템의 신뢰에 대한 이해
장영훈,이환수 한국경영정보학회 2017 한국경영정보학회 학술대회논문집 Vol.2017 No.12
중국에서는 모바일 지불 시스템인 알리페이와 위챗페이의 광범위한 사용과 각종 기타 디지털 지불 시스템 및 핀테크의 발전으로 기존 화폐 즉 현금 없이도 일상적인 삶을 살아가는데 아무런 지장이 없을 정도가 되었다. 큰 디지털격차가 존재하는 중국에서 디지털화폐의 혁명이 일어나고 있고, 대도시, 중소도시, 농촌 및 도서 지역 어디서든지 디지털 화폐를 사용할 수 있게 된 원인은 무엇인가? 본 연구에서는 이러한 디지털 화폐의 활발한 사용과 무현금 사회로 진입에 큰 역할은 하고 있는 20~30대 젊은 세대를 대상으로 기존 시민들의 ICT 관련 활용 및 디지털 격차에서 중요하게 보고 있는 네 개의 디지털 접근성 요인들과 사회시스템에 대한 신뢰의 개념을 도입하여 개인 소비자들의 디지털 화폐의 사용의도에 영향을 미치는 중요 요인에 대해 논의한다.