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Nordihydroguiaretic Acid 의 Bleomycin 유발 폐섬유증 발생 억제 효과
장귀련(Gui Lyen Jang),박낭운(Rang Woon Park),조준승(Joon Seung Jo) 대한내과학회 1991 대한내과학회지 Vol.41 No.3
N/A The inhibitory effect of nordihydroguiaretic acid (NDGA), a lipooxygenase inhibitor, on bleomylcininduced pulmonary fibrosis in rat was evaluated. Administration of bleomycin caused loss of body weight, increase of lung weight and of lung weight to body weight ratio. NDGA, however, appeared to have protective effects against these changes induced by bleomycin. In addition, NDGA reduced the mRNA level of pulmonary collagen and fibronectin both of which were elevated by bleomycin. The effect of NDGA was also evaluated by monitoring the level of albumin, total protein, hydroxyproline and the activity of N-acetyl-D-glucosaminidase and angiotensin-converting enzyme in bronchoalveolar lavage fluid. Levels of all these biochemir.al parameters were elevated by bleomycin and reverted by NDGA, In conclusion, NDGA reduced the toxic and fibrogenic effects of bleomycin and therfore it could be used as a therapeutic agent against lung damage and fibrosis resulting from various causes.
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장귀련(Gui Lyen Jang),정진영(Jin Young Chung),김원근(Won Kun Kim),김교선(Koy Sun Kim),김중구(Joong Gu Kim),김용진(Yong Jin Kim),박봉기(Bong Ki Park),황석순(Suk Soon Hwang),강문규(Moon Kyu Kang) 대한내과학회 1989 대한내과학회지 Vol.37 No.3
N/A We studied 12 cases of gastric anisakiasis who contacted the Dept. of Internal Medicine of St. Mary's Hospital and Sun Rin Hospital, Pohang, from March 1986 to Feb. 1989 and were confirmed by gastrofiberscopic findings and removal of larva of Anisakis. Our analysis gave the following results: 1) Of 12 cases, the sex ratio was 1 to 1,4 (male to female) and the 40s age group was most common, followed by the 30s, the 20s and 60s, in order of frequency. 2) In terms of seasonal incidence, May to July showed 6 cases (50%). Among causative fish, Astroconcer myriaster caused 6 cases (50%) and showed highest freguency. 3) The most common symptoms when the patients contacted the hospital were epigastric pain in 9 cases (75%) followed by nausea, epigastric fullness, and vomiting in order of frequency. 4) The onset of symptoms in 8 cases (66.7%) was within 6 hours since ingestion of those fish. 5) Six cases (50%) underwent gastrofiberscopic exam within 24 hours of onset of symptoms. 6) The most commonly involved site of the stomach was the anterior wall of the mid body (4 cases). The gastrofiberscopic findings were, in frequency of incidence, normal mucosa with larva (5 cases), erosion, hyperemia, mucosal thickening, petechia and ulceration. 7) We performed a biopsy in 4 among 12 cases, and the microscopic findings of the gastric mucosa were congestion and edema, broadening of the foveolar ridge and inflammatory cell infiltration, especially eosinophils and lymphocytes. The antral mucosa revealed findings of chronic superficial gastritis and small fragmental necrotic debris was seen along the surface of the mucosa. Early gastroscopic examination may be very useful in the diagnosis and treatment of anisakiasis if anisakiasis is clinically suspected, In addition, the general public should be enlightened that ocean fish are not necessarily safe when they are eaten a raw and a more detailed epidemiologic study should be conducted for anisakiasis.
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이상혁,박헌식,장세영,김재희,박선희,류현민,장귀련 대한심장학회 2008 Korean Circulation Journal Vol.38 No.12
This report describes the case of a 68-year-old man who presented with claudication and discoloration of his right lower extremity. He was a 35 pack-year smoker and had diabetes mellitus. The right common iliac artery was shown to be significantly obstructed on an angiogram. One self-expandable stent was deployed at the lesion. Three months later, however, he visited our hospital again due to recurrent claudication. An angiogram revealed in-stent reocclusion of the right common iliac artery. We used a transradial approach and penetrated the lesion with a percutaneous coronary intervention (PCI) guidewire, and dilated the lesion with a PCI balloon. The outcome was favorable. This report describes the case of a 68-year-old man who presented with claudication and discoloration of his right lower extremity. He was a 35 pack-year smoker and had diabetes mellitus. The right common iliac artery was shown to be significantly obstructed on an angiogram. One self-expandable stent was deployed at the lesion. Three months later, however, he visited our hospital again due to recurrent claudication. An angiogram revealed in-stent reocclusion of the right common iliac artery. We used a transradial approach and penetrated the lesion with a percutaneous coronary intervention (PCI) guidewire, and dilated the lesion with a PCI balloon. The outcome was favorable.
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이원식,정진영,정태훈,강현철,김재식,박은미,김교선,장귀련,이원길 대한내과학회 1989 대한내과학회지 Vol.36 No.1
A case of pulmonary cryptococcosis is reported and the literature on the subject is reviewed. A 20 year-old previously healthy fermale presented with chest pain, cough, geny al weakness and mild fever of 2 months duration. The chest X-ray showed infiltrative lesions with cavities in the left upper lobe. Cryptococcus neoformans was isolated in the specimens obtained by bronchial washings along with transbronchial lung biopsies, and its pathogenicity was assessed by animal inoculation. Clinical improvement was noted after 6 weeks of combined therapy with amphotericin B and 5-flucytosine.
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